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Gene: C1orf53 |
Gene summary for C1ORF53 |
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Gene information | Species | Human | Gene symbol | C1orf53 | Gene ID | 388722 |
Gene name | chromosome 1 open reading frame 53 | |
Gene Alias | C1orf53 | |
Cytomap | 1q31.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5VUE5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388722 | C1orf53 | LZE7T | Human | Esophagus | ESCC | 2.12e-05 | 3.84e-01 | 0.0667 |
388722 | C1orf53 | LZE22D1 | Human | Esophagus | HGIN | 3.25e-02 | 1.86e-01 | 0.0595 |
388722 | C1orf53 | P2T-E | Human | Esophagus | ESCC | 2.90e-02 | 1.36e-01 | 0.1177 |
388722 | C1orf53 | P4T-E | Human | Esophagus | ESCC | 1.74e-09 | 3.31e-01 | 0.1323 |
388722 | C1orf53 | P5T-E | Human | Esophagus | ESCC | 2.04e-05 | 1.31e-01 | 0.1327 |
388722 | C1orf53 | P8T-E | Human | Esophagus | ESCC | 2.65e-13 | 3.37e-01 | 0.0889 |
388722 | C1orf53 | P9T-E | Human | Esophagus | ESCC | 8.61e-09 | 2.63e-01 | 0.1131 |
388722 | C1orf53 | P10T-E | Human | Esophagus | ESCC | 1.15e-18 | 4.34e-01 | 0.116 |
388722 | C1orf53 | P11T-E | Human | Esophagus | ESCC | 2.51e-04 | 2.79e-01 | 0.1426 |
388722 | C1orf53 | P12T-E | Human | Esophagus | ESCC | 2.59e-04 | 1.58e-01 | 0.1122 |
388722 | C1orf53 | P15T-E | Human | Esophagus | ESCC | 3.66e-05 | 2.21e-01 | 0.1149 |
388722 | C1orf53 | P16T-E | Human | Esophagus | ESCC | 2.18e-03 | 1.55e-01 | 0.1153 |
388722 | C1orf53 | P19T-E | Human | Esophagus | ESCC | 2.51e-02 | 3.60e-01 | 0.1662 |
388722 | C1orf53 | P20T-E | Human | Esophagus | ESCC | 4.71e-10 | 2.98e-01 | 0.1124 |
388722 | C1orf53 | P21T-E | Human | Esophagus | ESCC | 2.38e-09 | 2.15e-01 | 0.1617 |
388722 | C1orf53 | P22T-E | Human | Esophagus | ESCC | 1.96e-11 | 2.76e-01 | 0.1236 |
388722 | C1orf53 | P23T-E | Human | Esophagus | ESCC | 1.34e-20 | 5.83e-01 | 0.108 |
388722 | C1orf53 | P26T-E | Human | Esophagus | ESCC | 9.43e-19 | 3.58e-01 | 0.1276 |
388722 | C1orf53 | P28T-E | Human | Esophagus | ESCC | 7.73e-18 | 3.86e-01 | 0.1149 |
388722 | C1orf53 | P30T-E | Human | Esophagus | ESCC | 6.19e-14 | 5.85e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf53 | SNV | Missense_Mutation | novel | c.401C>T | p.Ser134Phe | p.S134F | Q5VUE5 | protein_coding | deleterious(0.01) | benign(0.031) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf53 | SNV | Missense_Mutation | c.322N>A | p.Ala108Thr | p.A108T | Q5VUE5 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C1orf53 | SNV | Missense_Mutation | novel | c.314N>T | p.Thr105Ile | p.T105I | Q5VUE5 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf53 | SNV | Missense_Mutation | novel | c.273G>T | p.Gln91His | p.Q91H | Q5VUE5 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
C1orf53 | SNV | Missense_Mutation | c.269G>A | p.Gly90Asp | p.G90D | Q5VUE5 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
C1orf53 | SNV | Missense_Mutation | rs372599540 | c.356C>T | p.Ala119Val | p.A119V | Q5VUE5 | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf53 | SNV | Missense_Mutation | novel | c.317N>C | p.Gln106Pro | p.Q106P | Q5VUE5 | protein_coding | tolerated(0.08) | benign(0.341) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf53 | SNV | Missense_Mutation | novel | c.19T>G | p.Trp7Gly | p.W7G | Q5VUE5 | protein_coding | tolerated_low_confidence(0.22) | benign(0.031) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C1orf53 | SNV | Missense_Mutation | rs779133381 | c.238N>A | p.Ala80Thr | p.A80T | Q5VUE5 | protein_coding | tolerated(0.39) | benign(0.23) | TCGA-CC-A9FW-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
C1orf53 | SNV | Missense_Mutation | c.335G>A | p.Arg112Lys | p.R112K | Q5VUE5 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-34-5234-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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