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Gene: C1orf35 |
Gene summary for C1ORF35 |
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Gene information | Species | Human | Gene symbol | C1orf35 | Gene ID | 79169 |
Gene name | chromosome 1 open reading frame 35 | |
Gene Alias | MMTAG2 | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BU76 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79169 | C1orf35 | LZE2T | Human | Esophagus | ESCC | 2.72e-14 | 1.30e+00 | 0.082 |
79169 | C1orf35 | LZE4T | Human | Esophagus | ESCC | 4.84e-09 | 3.73e-01 | 0.0811 |
79169 | C1orf35 | LZE7T | Human | Esophagus | ESCC | 1.23e-21 | 8.07e-01 | 0.0667 |
79169 | C1orf35 | LZE8T | Human | Esophagus | ESCC | 4.88e-05 | 1.59e-01 | 0.067 |
79169 | C1orf35 | LZE20T | Human | Esophagus | ESCC | 4.38e-19 | 4.92e-01 | 0.0662 |
79169 | C1orf35 | LZE21D1 | Human | Esophagus | HGIN | 1.16e-02 | 4.58e-01 | 0.0632 |
79169 | C1orf35 | LZE22D1 | Human | Esophagus | HGIN | 8.79e-07 | 3.09e-01 | 0.0595 |
79169 | C1orf35 | LZE22T | Human | Esophagus | ESCC | 1.04e-11 | 6.10e-01 | 0.068 |
79169 | C1orf35 | LZE24T | Human | Esophagus | ESCC | 7.79e-26 | 5.99e-01 | 0.0596 |
79169 | C1orf35 | LZE21T | Human | Esophagus | ESCC | 9.68e-10 | 5.37e-01 | 0.0655 |
79169 | C1orf35 | P1T-E | Human | Esophagus | ESCC | 1.51e-29 | 1.16e+00 | 0.0875 |
79169 | C1orf35 | P2T-E | Human | Esophagus | ESCC | 3.15e-53 | 1.05e+00 | 0.1177 |
79169 | C1orf35 | P4T-E | Human | Esophagus | ESCC | 1.21e-25 | 6.66e-01 | 0.1323 |
79169 | C1orf35 | P5T-E | Human | Esophagus | ESCC | 1.45e-57 | 1.00e+00 | 0.1327 |
79169 | C1orf35 | P8T-E | Human | Esophagus | ESCC | 4.91e-29 | 5.36e-01 | 0.0889 |
79169 | C1orf35 | P9T-E | Human | Esophagus | ESCC | 1.69e-35 | 6.98e-01 | 0.1131 |
79169 | C1orf35 | P10T-E | Human | Esophagus | ESCC | 4.16e-39 | 7.02e-01 | 0.116 |
79169 | C1orf35 | P11T-E | Human | Esophagus | ESCC | 2.68e-19 | 8.54e-01 | 0.1426 |
79169 | C1orf35 | P12T-E | Human | Esophagus | ESCC | 4.01e-31 | 6.75e-01 | 0.1122 |
79169 | C1orf35 | P15T-E | Human | Esophagus | ESCC | 8.55e-47 | 9.72e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf35 | SNV | Missense_Mutation | c.280N>A | p.Leu94Met | p.L94M | Q9BU76 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
C1orf35 | SNV | Missense_Mutation | novel | c.264N>T | p.Lys88Asn | p.K88N | Q9BU76 | protein_coding | tolerated(0.06) | benign(0.146) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | novel | c.550N>G | p.Lys184Glu | p.K184E | Q9BU76 | protein_coding | tolerated(0.28) | probably_damaging(0.968) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | rs748613886 | c.658T>C | p.Ser220Pro | p.S220P | Q9BU76 | protein_coding | tolerated(0.11) | benign(0.202) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | rs534724964 | c.629N>A | p.Arg210Gln | p.R210Q | Q9BU76 | protein_coding | tolerated(0.07) | benign(0) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | rs140393278 | c.761N>A | p.Arg254His | p.R254H | Q9BU76 | protein_coding | tolerated_low_confidence(0.48) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | novel | c.470G>A | p.Gly157Glu | p.G157E | Q9BU76 | protein_coding | tolerated(0.97) | benign(0.08) | TCGA-UB-AA0U-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
C1orf35 | SNV | Missense_Mutation | c.437N>G | p.Ser146Cys | p.S146C | Q9BU76 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-69-7760-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C1orf35 | SNV | Missense_Mutation | novel | c.80N>T | p.Arg27Leu | p.R27L | Q9BU76 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-91-6835-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf35 | SNV | Missense_Mutation | novel | c.28N>G | p.Arg10Gly | p.R10G | Q9BU76 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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