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Gene: C1orf159 |
Gene summary for C1ORF159 |
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Gene information | Species | Human | Gene symbol | C1orf159 | Gene ID | 54991 |
Gene name | chromosome 1 open reading frame 159 | |
Gene Alias | C1orf159 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96HA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54991 | C1orf159 | CCI_1 | Human | Cervix | CC | 1.48e-05 | 5.56e-01 | 0.528 |
54991 | C1orf159 | CCI_2 | Human | Cervix | CC | 1.88e-06 | 6.07e-01 | 0.5249 |
54991 | C1orf159 | CCI_3 | Human | Cervix | CC | 8.08e-07 | 4.63e-01 | 0.516 |
54991 | C1orf159 | LZE7T | Human | Esophagus | ESCC | 1.17e-04 | 1.60e-01 | 0.0667 |
54991 | C1orf159 | LZE20T | Human | Esophagus | ESCC | 2.74e-03 | 1.36e-01 | 0.0662 |
54991 | C1orf159 | LZE24T | Human | Esophagus | ESCC | 8.67e-10 | 1.40e-01 | 0.0596 |
54991 | C1orf159 | P1T-E | Human | Esophagus | ESCC | 6.58e-03 | 1.29e-01 | 0.0875 |
54991 | C1orf159 | P2T-E | Human | Esophagus | ESCC | 6.73e-26 | 2.28e-01 | 0.1177 |
54991 | C1orf159 | P4T-E | Human | Esophagus | ESCC | 1.13e-13 | 2.25e-01 | 0.1323 |
54991 | C1orf159 | P5T-E | Human | Esophagus | ESCC | 8.07e-11 | 7.33e-02 | 0.1327 |
54991 | C1orf159 | P8T-E | Human | Esophagus | ESCC | 6.37e-12 | 2.54e-01 | 0.0889 |
54991 | C1orf159 | P10T-E | Human | Esophagus | ESCC | 7.14e-08 | 1.86e-01 | 0.116 |
54991 | C1orf159 | P12T-E | Human | Esophagus | ESCC | 3.05e-11 | 9.34e-02 | 0.1122 |
54991 | C1orf159 | P15T-E | Human | Esophagus | ESCC | 3.19e-11 | 1.29e-01 | 0.1149 |
54991 | C1orf159 | P16T-E | Human | Esophagus | ESCC | 2.71e-08 | 1.03e-01 | 0.1153 |
54991 | C1orf159 | P17T-E | Human | Esophagus | ESCC | 1.37e-03 | 1.57e-01 | 0.1278 |
54991 | C1orf159 | P20T-E | Human | Esophagus | ESCC | 5.56e-14 | 2.03e-01 | 0.1124 |
54991 | C1orf159 | P21T-E | Human | Esophagus | ESCC | 6.04e-18 | 2.53e-01 | 0.1617 |
54991 | C1orf159 | P22T-E | Human | Esophagus | ESCC | 3.46e-08 | 6.81e-02 | 0.1236 |
54991 | C1orf159 | P23T-E | Human | Esophagus | ESCC | 6.26e-04 | 1.61e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf159 | SNV | Missense_Mutation | c.892N>A | p.Glu298Lys | p.E298K | Q96HA4 | protein_coding | tolerated_low_confidence(0.16) | benign(0.235) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
C1orf159 | SNV | Missense_Mutation | c.602A>G | p.Gln201Arg | p.Q201R | Q96HA4 | protein_coding | deleterious(0.01) | possibly_damaging(0.636) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C1orf159 | SNV | Missense_Mutation | c.421N>C | p.Ala141Pro | p.A141P | Q96HA4 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C1orf159 | SNV | Missense_Mutation | rs772422279 | c.455C>T | p.Thr152Met | p.T152M | Q96HA4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf159 | SNV | Missense_Mutation | rs749632934 | c.730N>A | p.Gly244Arg | p.G244R | Q96HA4 | protein_coding | tolerated_low_confidence(0.35) | benign(0.001) | TCGA-AD-6888-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
C1orf159 | SNV | Missense_Mutation | rs570180103 | c.769N>T | p.Arg257Trp | p.R257W | Q96HA4 | protein_coding | tolerated_low_confidence(0.07) | benign(0) | TCGA-D5-6923-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C1orf159 | deletion | Frame_Shift_Del | c.131delN | p.Pro44GlnfsTer84 | p.P44Qfs*84 | Q96HA4 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
C1orf159 | SNV | Missense_Mutation | novel | c.1012N>G | p.Ser338Gly | p.S338G | Q96HA4 | protein_coding | deleterious_low_confidence(0.05) | benign(0.031) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
C1orf159 | SNV | Missense_Mutation | rs147852840 | c.856A>G | p.Met286Val | p.M286V | Q96HA4 | protein_coding | tolerated_low_confidence(0.54) | benign(0.005) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf159 | SNV | Missense_Mutation | rs762881637 | c.617G>A | p.Ser206Asn | p.S206N | Q96HA4 | protein_coding | deleterious(0.04) | benign(0.012) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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