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Gene: C1orf131 |
Gene summary for C1ORF131 |
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Gene information | Species | Human | Gene symbol | C1orf131 | Gene ID | 128061 |
Gene name | chromosome 1 open reading frame 131 | |
Gene Alias | C1orf131 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NDD1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128061 | C1orf131 | LZE2T | Human | Esophagus | ESCC | 1.86e-04 | 5.61e-01 | 0.082 |
128061 | C1orf131 | LZE4T | Human | Esophagus | ESCC | 2.86e-15 | 4.68e-01 | 0.0811 |
128061 | C1orf131 | LZE7T | Human | Esophagus | ESCC | 5.40e-08 | 6.13e-01 | 0.0667 |
128061 | C1orf131 | LZE20T | Human | Esophagus | ESCC | 6.54e-04 | 1.72e-01 | 0.0662 |
128061 | C1orf131 | LZE24T | Human | Esophagus | ESCC | 1.51e-10 | 3.98e-01 | 0.0596 |
128061 | C1orf131 | LZE21T | Human | Esophagus | ESCC | 5.81e-03 | 4.23e-01 | 0.0655 |
128061 | C1orf131 | P1T-E | Human | Esophagus | ESCC | 1.67e-12 | 7.29e-01 | 0.0875 |
128061 | C1orf131 | P2T-E | Human | Esophagus | ESCC | 3.45e-31 | 6.04e-01 | 0.1177 |
128061 | C1orf131 | P4T-E | Human | Esophagus | ESCC | 1.04e-19 | 5.92e-01 | 0.1323 |
128061 | C1orf131 | P5T-E | Human | Esophagus | ESCC | 7.05e-34 | 6.30e-01 | 0.1327 |
128061 | C1orf131 | P8T-E | Human | Esophagus | ESCC | 7.80e-28 | 4.66e-01 | 0.0889 |
128061 | C1orf131 | P9T-E | Human | Esophagus | ESCC | 2.30e-23 | 6.83e-01 | 0.1131 |
128061 | C1orf131 | P10T-E | Human | Esophagus | ESCC | 2.78e-35 | 6.82e-01 | 0.116 |
128061 | C1orf131 | P11T-E | Human | Esophagus | ESCC | 1.78e-08 | 4.68e-01 | 0.1426 |
128061 | C1orf131 | P12T-E | Human | Esophagus | ESCC | 5.62e-14 | 3.02e-01 | 0.1122 |
128061 | C1orf131 | P15T-E | Human | Esophagus | ESCC | 6.31e-23 | 5.57e-01 | 0.1149 |
128061 | C1orf131 | P16T-E | Human | Esophagus | ESCC | 4.14e-24 | 4.45e-01 | 0.1153 |
128061 | C1orf131 | P17T-E | Human | Esophagus | ESCC | 6.16e-08 | 2.68e-01 | 0.1278 |
128061 | C1orf131 | P19T-E | Human | Esophagus | ESCC | 7.91e-05 | 6.51e-01 | 0.1662 |
128061 | C1orf131 | P20T-E | Human | Esophagus | ESCC | 4.98e-20 | 5.71e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf131 | SNV | Missense_Mutation | rs552479895 | c.22N>A | p.Asp8Asn | p.D8N | Q8NDD1 | protein_coding | deleterious_low_confidence(0) | benign(0.167) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf131 | SNV | Missense_Mutation | rs765943386 | c.547N>C | p.Tyr183His | p.Y183H | Q8NDD1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
C1orf131 | SNV | Missense_Mutation | rs531305779 | c.17N>T | p.Ser6Leu | p.S6L | Q8NDD1 | protein_coding | tolerated_low_confidence(0.37) | benign(0) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C1orf131 | SNV | Missense_Mutation | novel | c.778T>G | p.Leu260Val | p.L260V | Q8NDD1 | protein_coding | tolerated(0.05) | possibly_damaging(0.651) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C1orf131 | SNV | Missense_Mutation | c.746N>T | p.Arg249Met | p.R249M | Q8NDD1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C1orf131 | SNV | Missense_Mutation | rs772202745 | c.263C>T | p.Ser88Leu | p.S88L | Q8NDD1 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C1orf131 | deletion | Frame_Shift_Del | novel | c.665delA | p.Lys222ArgfsTer55 | p.K222Rfs*55 | Q8NDD1 | protein_coding | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
C1orf131 | SNV | Missense_Mutation | novel | c.251N>T | p.Arg84Met | p.R84M | Q8NDD1 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C1orf131 | SNV | Missense_Mutation | c.430N>T | p.Asp144Tyr | p.D144Y | Q8NDD1 | protein_coding | deleterious(0.01) | possibly_damaging(0.814) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf131 | SNV | Missense_Mutation | novel | c.611C>A | p.Pro204His | p.P204H | Q8NDD1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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