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Gene: C1orf123 |
Gene summary for C1ORF123 |
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Gene information | Species | Human | Gene symbol | C1orf123 | Gene ID | 54987 |
Gene name | CXXC motif containing zinc binding protein | |
Gene Alias | C1orf123 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NWV4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54987 | C1orf123 | P1T-E | Human | Esophagus | ESCC | 2.04e-04 | 3.47e-01 | 0.0875 |
54987 | C1orf123 | P2T-E | Human | Esophagus | ESCC | 2.92e-22 | 4.68e-01 | 0.1177 |
54987 | C1orf123 | P4T-E | Human | Esophagus | ESCC | 7.81e-22 | 4.17e-01 | 0.1323 |
54987 | C1orf123 | P5T-E | Human | Esophagus | ESCC | 6.12e-16 | 3.60e-01 | 0.1327 |
54987 | C1orf123 | P8T-E | Human | Esophagus | ESCC | 6.89e-33 | 6.17e-01 | 0.0889 |
54987 | C1orf123 | P9T-E | Human | Esophagus | ESCC | 2.35e-18 | 3.79e-01 | 0.1131 |
54987 | C1orf123 | P10T-E | Human | Esophagus | ESCC | 1.15e-51 | 7.19e-01 | 0.116 |
54987 | C1orf123 | P11T-E | Human | Esophagus | ESCC | 7.74e-14 | 7.23e-01 | 0.1426 |
54987 | C1orf123 | P12T-E | Human | Esophagus | ESCC | 4.82e-19 | 4.14e-01 | 0.1122 |
54987 | C1orf123 | P15T-E | Human | Esophagus | ESCC | 3.31e-18 | 3.16e-01 | 0.1149 |
54987 | C1orf123 | P16T-E | Human | Esophagus | ESCC | 5.77e-18 | 2.80e-01 | 0.1153 |
54987 | C1orf123 | P17T-E | Human | Esophagus | ESCC | 1.27e-08 | 4.15e-01 | 0.1278 |
54987 | C1orf123 | P19T-E | Human | Esophagus | ESCC | 1.23e-05 | 6.36e-01 | 0.1662 |
54987 | C1orf123 | P20T-E | Human | Esophagus | ESCC | 4.38e-17 | 4.01e-01 | 0.1124 |
54987 | C1orf123 | P21T-E | Human | Esophagus | ESCC | 8.22e-43 | 8.57e-01 | 0.1617 |
54987 | C1orf123 | P22T-E | Human | Esophagus | ESCC | 6.41e-16 | 3.16e-01 | 0.1236 |
54987 | C1orf123 | P23T-E | Human | Esophagus | ESCC | 4.28e-18 | 4.61e-01 | 0.108 |
54987 | C1orf123 | P24T-E | Human | Esophagus | ESCC | 1.54e-23 | 3.98e-01 | 0.1287 |
54987 | C1orf123 | P26T-E | Human | Esophagus | ESCC | 2.81e-16 | 3.02e-01 | 0.1276 |
54987 | C1orf123 | P27T-E | Human | Esophagus | ESCC | 3.93e-18 | 4.41e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf123 | SNV | Missense_Mutation | novel | c.150N>A | p.Asp50Glu | p.D50E | Q9NWV4 | protein_coding | tolerated(1) | benign(0.014) | TCGA-E2-A1IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
C1orf123 | insertion | Frame_Shift_Ins | novel | c.179_180insGGATGGTGGGCTTAAA | p.Ser60ArgfsTer35 | p.S60Rfs*35 | Q9NWV4 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
C1orf123 | insertion | Frame_Shift_Ins | novel | c.17_18insTAGCATATTCACCTCAAACGTGTATCATTTCTTTGTGTTGGGA | p.Gln7SerfsTer46 | p.Q7Sfs*46 | Q9NWV4 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
C1orf123 | SNV | Missense_Mutation | rs377269419 | c.67N>A | p.Glu23Lys | p.E23K | Q9NWV4 | protein_coding | tolerated(0.15) | benign(0.433) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
C1orf123 | SNV | Missense_Mutation | rs377269419 | c.67N>A | p.Glu23Lys | p.E23K | Q9NWV4 | protein_coding | tolerated(0.15) | benign(0.433) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf123 | SNV | Missense_Mutation | novel | c.350C>T | p.Ala117Val | p.A117V | Q9NWV4 | protein_coding | tolerated(0.38) | benign(0.026) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
C1orf123 | SNV | Missense_Mutation | novel | c.215N>C | p.Arg72Thr | p.R72T | Q9NWV4 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C1orf123 | SNV | Missense_Mutation | c.358N>T | p.Gly120Cys | p.G120C | Q9NWV4 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf123 | SNV | Missense_Mutation | c.41N>G | p.Asn14Ser | p.N14S | Q9NWV4 | protein_coding | deleterious(0.02) | possibly_damaging(0.806) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C1orf123 | SNV | Missense_Mutation | c.371G>T | p.Gly124Val | p.G124V | Q9NWV4 | protein_coding | deleterious(0.02) | possibly_damaging(0.719) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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