|
Gene: C19orf52 |
Gene summary for C19ORF52 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C19orf52 | Gene ID | 90580 |
Gene name | translocase of inner mitochondrial membrane 29 | |
Gene Alias | C19orf52 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q9BSF4 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90580 | C19orf52 | P1T-E | Human | Esophagus | ESCC | 1.65e-02 | 2.33e-01 | 0.0875 |
90580 | C19orf52 | P2T-E | Human | Esophagus | ESCC | 1.57e-09 | 1.87e-01 | 0.1177 |
90580 | C19orf52 | P4T-E | Human | Esophagus | ESCC | 1.05e-21 | 5.60e-01 | 0.1323 |
90580 | C19orf52 | P5T-E | Human | Esophagus | ESCC | 1.64e-13 | 3.26e-01 | 0.1327 |
90580 | C19orf52 | P8T-E | Human | Esophagus | ESCC | 5.71e-20 | 2.06e-01 | 0.0889 |
90580 | C19orf52 | P9T-E | Human | Esophagus | ESCC | 6.69e-16 | 3.69e-01 | 0.1131 |
90580 | C19orf52 | P10T-E | Human | Esophagus | ESCC | 1.73e-25 | 4.34e-01 | 0.116 |
90580 | C19orf52 | P11T-E | Human | Esophagus | ESCC | 1.24e-03 | 1.93e-01 | 0.1426 |
90580 | C19orf52 | P12T-E | Human | Esophagus | ESCC | 4.84e-23 | 3.97e-01 | 0.1122 |
90580 | C19orf52 | P15T-E | Human | Esophagus | ESCC | 9.61e-22 | 4.95e-01 | 0.1149 |
90580 | C19orf52 | P16T-E | Human | Esophagus | ESCC | 4.98e-14 | 2.51e-01 | 0.1153 |
90580 | C19orf52 | P19T-E | Human | Esophagus | ESCC | 6.38e-03 | 3.90e-01 | 0.1662 |
90580 | C19orf52 | P20T-E | Human | Esophagus | ESCC | 1.17e-17 | 3.83e-01 | 0.1124 |
90580 | C19orf52 | P21T-E | Human | Esophagus | ESCC | 2.86e-17 | 2.86e-01 | 0.1617 |
90580 | C19orf52 | P22T-E | Human | Esophagus | ESCC | 6.10e-35 | 5.45e-01 | 0.1236 |
90580 | C19orf52 | P23T-E | Human | Esophagus | ESCC | 1.53e-20 | 4.47e-01 | 0.108 |
90580 | C19orf52 | P24T-E | Human | Esophagus | ESCC | 8.87e-18 | 2.43e-01 | 0.1287 |
90580 | C19orf52 | P26T-E | Human | Esophagus | ESCC | 2.34e-29 | 4.88e-01 | 0.1276 |
90580 | C19orf52 | P27T-E | Human | Esophagus | ESCC | 5.58e-19 | 2.92e-01 | 0.1055 |
90580 | C19orf52 | P28T-E | Human | Esophagus | ESCC | 1.22e-35 | 6.30e-01 | 0.1149 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |