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Gene: C19orf24 |
Gene summary for C19ORF24 |
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Gene information | Species | Human | Gene symbol | C19orf24 | Gene ID | 55009 |
Gene name | family with sequence similarity 174 member C | |
Gene Alias | C19orf24 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BVV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55009 | C19orf24 | P1T-E | Human | Esophagus | ESCC | 1.01e-19 | 1.00e+00 | 0.0875 |
55009 | C19orf24 | P2T-E | Human | Esophagus | ESCC | 1.32e-26 | 5.46e-01 | 0.1177 |
55009 | C19orf24 | P4T-E | Human | Esophagus | ESCC | 5.37e-45 | 1.28e+00 | 0.1323 |
55009 | C19orf24 | P5T-E | Human | Esophagus | ESCC | 3.65e-39 | 7.56e-01 | 0.1327 |
55009 | C19orf24 | P8T-E | Human | Esophagus | ESCC | 1.67e-11 | 2.67e-01 | 0.0889 |
55009 | C19orf24 | P9T-E | Human | Esophagus | ESCC | 2.16e-63 | 1.63e+00 | 0.1131 |
55009 | C19orf24 | P10T-E | Human | Esophagus | ESCC | 7.63e-74 | 1.40e+00 | 0.116 |
55009 | C19orf24 | P11T-E | Human | Esophagus | ESCC | 3.50e-17 | 1.08e+00 | 0.1426 |
55009 | C19orf24 | P12T-E | Human | Esophagus | ESCC | 1.16e-26 | 5.46e-01 | 0.1122 |
55009 | C19orf24 | P15T-E | Human | Esophagus | ESCC | 7.77e-29 | 5.72e-01 | 0.1149 |
55009 | C19orf24 | P16T-E | Human | Esophagus | ESCC | 8.89e-25 | 5.86e-01 | 0.1153 |
55009 | C19orf24 | P17T-E | Human | Esophagus | ESCC | 7.67e-12 | 8.66e-01 | 0.1278 |
55009 | C19orf24 | P19T-E | Human | Esophagus | ESCC | 2.11e-12 | 8.96e-01 | 0.1662 |
55009 | C19orf24 | P20T-E | Human | Esophagus | ESCC | 3.18e-33 | 8.99e-01 | 0.1124 |
55009 | C19orf24 | P21T-E | Human | Esophagus | ESCC | 3.27e-73 | 1.41e+00 | 0.1617 |
55009 | C19orf24 | P22T-E | Human | Esophagus | ESCC | 1.06e-60 | 1.14e+00 | 0.1236 |
55009 | C19orf24 | P23T-E | Human | Esophagus | ESCC | 1.19e-55 | 1.61e+00 | 0.108 |
55009 | C19orf24 | P24T-E | Human | Esophagus | ESCC | 5.77e-47 | 1.17e+00 | 0.1287 |
55009 | C19orf24 | P26T-E | Human | Esophagus | ESCC | 4.42e-61 | 1.25e+00 | 0.1276 |
55009 | C19orf24 | P27T-E | Human | Esophagus | ESCC | 9.37e-25 | 4.61e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C19orf24 | SNV | Missense_Mutation | c.185C>A | p.Pro62Gln | p.P62Q | Q9BVV8 | protein_coding | tolerated(0.11) | possibly_damaging(0.574) | TCGA-4N-A93T-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | |
C19orf24 | deletion | In_Frame_Del | rs761097595 | c.219_221delNNN | p.Phe74del | p.F74del | Q9BVV8 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
C19orf24 | SNV | Missense_Mutation | novel | c.305N>A | p.Arg102Gln | p.R102Q | Q9BVV8 | protein_coding | deleterious(0.01) | benign(0.416) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C19orf24 | SNV | Missense_Mutation | novel | c.361N>A | p.Asp121Asn | p.D121N | Q9BVV8 | protein_coding | deleterious(0.04) | benign(0.2) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
C19orf24 | deletion | In_Frame_Del | novel | c.244_246delGGC | p.Gly82del | p.G82del | Q9BVV8 | protein_coding | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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