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Gene: C17orf89 |
Gene summary for C17ORF89 |
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Gene information | Species | Human | Gene symbol | C17orf89 | Gene ID | 284184 |
Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 8 | |
Gene Alias | C17orf89 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A1L188 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284184 | C17orf89 | P1T-E | Human | Esophagus | ESCC | 2.45e-12 | 6.95e-01 | 0.0875 |
284184 | C17orf89 | P2T-E | Human | Esophagus | ESCC | 5.69e-40 | 1.02e+00 | 0.1177 |
284184 | C17orf89 | P4T-E | Human | Esophagus | ESCC | 4.87e-44 | 1.22e+00 | 0.1323 |
284184 | C17orf89 | P5T-E | Human | Esophagus | ESCC | 5.48e-56 | 1.41e+00 | 0.1327 |
284184 | C17orf89 | P8T-E | Human | Esophagus | ESCC | 1.25e-21 | 5.65e-01 | 0.0889 |
284184 | C17orf89 | P9T-E | Human | Esophagus | ESCC | 3.50e-36 | 1.00e+00 | 0.1131 |
284184 | C17orf89 | P10T-E | Human | Esophagus | ESCC | 1.16e-51 | 1.06e+00 | 0.116 |
284184 | C17orf89 | P11T-E | Human | Esophagus | ESCC | 5.35e-25 | 1.32e+00 | 0.1426 |
284184 | C17orf89 | P12T-E | Human | Esophagus | ESCC | 8.67e-40 | 9.34e-01 | 0.1122 |
284184 | C17orf89 | P15T-E | Human | Esophagus | ESCC | 1.65e-38 | 1.11e+00 | 0.1149 |
284184 | C17orf89 | P16T-E | Human | Esophagus | ESCC | 5.74e-34 | 9.46e-01 | 0.1153 |
284184 | C17orf89 | P17T-E | Human | Esophagus | ESCC | 6.88e-18 | 9.57e-01 | 0.1278 |
284184 | C17orf89 | P19T-E | Human | Esophagus | ESCC | 4.23e-08 | 1.12e+00 | 0.1662 |
284184 | C17orf89 | P20T-E | Human | Esophagus | ESCC | 6.02e-79 | 1.94e+00 | 0.1124 |
284184 | C17orf89 | P21T-E | Human | Esophagus | ESCC | 1.35e-55 | 1.53e+00 | 0.1617 |
284184 | C17orf89 | P22T-E | Human | Esophagus | ESCC | 2.38e-79 | 1.54e+00 | 0.1236 |
284184 | C17orf89 | P23T-E | Human | Esophagus | ESCC | 2.15e-51 | 1.10e+00 | 0.108 |
284184 | C17orf89 | P24T-E | Human | Esophagus | ESCC | 2.32e-50 | 1.21e+00 | 0.1287 |
284184 | C17orf89 | P26T-E | Human | Esophagus | ESCC | 5.77e-70 | 1.57e+00 | 0.1276 |
284184 | C17orf89 | P27T-E | Human | Esophagus | ESCC | 1.87e-32 | 6.22e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0471439 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714114 | Esophagus | HGIN | Thermogenesis | 91/1383 | 232/8465 | 1.97e-17 | 5.36e-16 | 4.25e-16 | 91 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0471412 | Stomach | GC | Thermogenesis | 56/708 | 232/8465 | 1.35e-13 | 4.32e-12 | 3.04e-12 | 56 |
hsa0471413 | Stomach | GC | Thermogenesis | 56/708 | 232/8465 | 1.35e-13 | 4.32e-12 | 3.04e-12 | 56 |
hsa0471421 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
hsa0471431 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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