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Gene: C16orf91 |
Gene summary for C16ORF91 |
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Gene information | Species | Human | Gene symbol | C16orf91 | Gene ID | 283951 |
Gene name | chromosome 16 open reading frame 91 | |
Gene Alias | CCSMST1 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A0A8K8N9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283951 | C16orf91 | LZE4T | Human | Esophagus | ESCC | 2.56e-06 | 1.28e-01 | 0.0811 |
283951 | C16orf91 | LZE7T | Human | Esophagus | ESCC | 2.03e-03 | 3.22e-01 | 0.0667 |
283951 | C16orf91 | LZE8T | Human | Esophagus | ESCC | 1.69e-05 | 2.33e-01 | 0.067 |
283951 | C16orf91 | LZE20T | Human | Esophagus | ESCC | 3.87e-02 | 1.88e-01 | 0.0662 |
283951 | C16orf91 | LZE24T | Human | Esophagus | ESCC | 2.01e-10 | 3.38e-01 | 0.0596 |
283951 | C16orf91 | P1T-E | Human | Esophagus | ESCC | 6.40e-07 | 4.90e-01 | 0.0875 |
283951 | C16orf91 | P2T-E | Human | Esophagus | ESCC | 5.68e-39 | 7.02e-01 | 0.1177 |
283951 | C16orf91 | P4T-E | Human | Esophagus | ESCC | 2.16e-21 | 6.53e-01 | 0.1323 |
283951 | C16orf91 | P5T-E | Human | Esophagus | ESCC | 1.14e-18 | 4.19e-01 | 0.1327 |
283951 | C16orf91 | P8T-E | Human | Esophagus | ESCC | 1.30e-13 | 2.57e-01 | 0.0889 |
283951 | C16orf91 | P9T-E | Human | Esophagus | ESCC | 7.21e-10 | 1.78e-01 | 0.1131 |
283951 | C16orf91 | P10T-E | Human | Esophagus | ESCC | 2.53e-19 | 2.49e-01 | 0.116 |
283951 | C16orf91 | P11T-E | Human | Esophagus | ESCC | 8.29e-09 | 6.13e-01 | 0.1426 |
283951 | C16orf91 | P12T-E | Human | Esophagus | ESCC | 1.82e-32 | 6.56e-01 | 0.1122 |
283951 | C16orf91 | P15T-E | Human | Esophagus | ESCC | 4.51e-17 | 3.57e-01 | 0.1149 |
283951 | C16orf91 | P16T-E | Human | Esophagus | ESCC | 3.79e-11 | 2.65e-01 | 0.1153 |
283951 | C16orf91 | P17T-E | Human | Esophagus | ESCC | 5.39e-08 | 2.63e-01 | 0.1278 |
283951 | C16orf91 | P19T-E | Human | Esophagus | ESCC | 5.55e-07 | 4.74e-01 | 0.1662 |
283951 | C16orf91 | P20T-E | Human | Esophagus | ESCC | 2.38e-16 | 3.79e-01 | 0.1124 |
283951 | C16orf91 | P21T-E | Human | Esophagus | ESCC | 2.15e-39 | 9.13e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf91 | SNV | Missense_Mutation | c.352C>T | p.Arg118Cys | p.R118C | Q4G0I0 | protein_coding | tolerated(0.05) | possibly_damaging(0.55) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
C16orf91 | SNV | Missense_Mutation | rs199709082 | c.298G>A | p.Glu100Lys | p.E100K | Q4G0I0 | protein_coding | tolerated(0.49) | benign(0.085) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C16orf91 | insertion | In_Frame_Ins | novel | c.110_111insACAACAAATGAAAATAAATTTTAATTTTATAATATG | p.His37delinsGlnGlnGlnMetLysIleAsnPheAsnPheIleIleCys | p.H37delinsQQQMKINFNFIIC | Q4G0I0 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C16orf91 | deletion | Frame_Shift_Del | novel | c.212delG | p.Gly71AspfsTer19 | p.G71Dfs*19 | Q4G0I0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C16orf91 | SNV | Missense_Mutation | c.95N>T | p.Ser32Phe | p.S32F | Q4G0I0 | protein_coding | deleterious(0.01) | benign(0.192) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
C16orf91 | SNV | Missense_Mutation | novel | c.392G>T | p.Arg131Ile | p.R131I | Q4G0I0 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C16orf91 | SNV | Missense_Mutation | c.234N>T | p.Lys78Asn | p.K78N | Q4G0I0 | protein_coding | deleterious(0.01) | benign(0.398) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C16orf91 | SNV | Missense_Mutation | c.242C>T | p.Pro81Leu | p.P81L | Q4G0I0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C16orf91 | SNV | Missense_Mutation | novel | c.4A>G | p.Asn2Asp | p.N2D | Q4G0I0 | protein_coding | tolerated(0.09) | benign(0.027) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf91 | SNV | Missense_Mutation | novel | c.20N>T | p.Ala7Val | p.A7V | Q4G0I0 | protein_coding | tolerated(0.22) | benign(0.005) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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