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Gene: C16orf89 |
Gene summary for C16ORF89 |
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Gene information | Species | Human | Gene symbol | C16orf89 | Gene ID | 146556 |
Gene name | chromosome 16 open reading frame 89 | |
Gene Alias | C16orf89 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6UX73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146556 | C16orf89 | TD9 | Human | Lung | IAC | 2.88e-08 | 2.83e-01 | 0.088 |
146556 | C16orf89 | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.86e-03 | -3.07e-01 | 0.3371 |
146556 | C16orf89 | RNA-P17T-P17T-4 | Human | Lung | IAC | 9.72e-03 | -4.25e-01 | 0.343 |
146556 | C16orf89 | RNA-P17T-P17T-6 | Human | Lung | IAC | 2.15e-02 | -5.62e-01 | 0.3385 |
146556 | C16orf89 | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.55e-02 | -3.25e-01 | 0.3329 |
146556 | C16orf89 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.14e-12 | 3.68e-01 | -0.2116 |
146556 | C16orf89 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 9.96e-06 | 2.02e-01 | -0.1941 |
146556 | C16orf89 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.70e-07 | 2.09e-01 | -0.2107 |
146556 | C16orf89 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.82e-08 | 2.34e-01 | -0.2119 |
146556 | C16orf89 | RNA-P3T-P3T-1 | Human | Lung | IAC | 8.07e-04 | -6.84e-01 | 0.1829 |
146556 | C16orf89 | RNA-P3T-P3T-4 | Human | Lung | IAC | 2.93e-05 | -6.27e-01 | 0.1859 |
146556 | C16orf89 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 9.27e-06 | -3.45e-01 | -0.0166 |
146556 | C16orf89 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.67e-12 | -1.72e-01 | -0.0132 |
146556 | C16orf89 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.31e-20 | -1.33e-01 | -0.013 |
146556 | C16orf89 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.02e-09 | -1.04e-01 | -0.0121 |
146556 | C16orf89 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 4.46e-05 | -4.97e-02 | -0.0961 |
146556 | C16orf89 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 5.48e-05 | -8.36e-02 | -0.0876 |
146556 | C16orf89 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.72e-02 | -1.53e-01 | -0.0822 |
146556 | C16orf89 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.13e-07 | 6.84e-02 | -0.0809 |
146556 | C16orf89 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.48e-26 | -8.26e-01 | 0.02 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf89 | SNV | Missense_Mutation | c.623N>A | p.Arg208Lys | p.R208K | Q6UX73 | protein_coding | tolerated(0.34) | benign(0.027) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C16orf89 | SNV | Missense_Mutation | c.880G>A | p.Glu294Lys | p.E294K | Q6UX73 | protein_coding | tolerated(0.3) | benign(0.013) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
C16orf89 | SNV | Missense_Mutation | novel | c.580N>T | p.Gly194Cys | p.G194C | Q6UX73 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf89 | SNV | Missense_Mutation | c.920C>T | p.Ser307Leu | p.S307L | Q6UX73 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C16orf89 | SNV | Missense_Mutation | novel | c.97G>T | p.Ala33Ser | p.A33S | Q6UX73 | protein_coding | tolerated(0.06) | possibly_damaging(0.696) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C16orf89 | SNV | Missense_Mutation | rs770082606 | c.782G>A | p.Gly261Asp | p.G261D | Q6UX73 | protein_coding | deleterious(0.01) | benign(0.397) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
C16orf89 | SNV | Missense_Mutation | c.771C>A | p.Phe257Leu | p.F257L | Q6UX73 | protein_coding | tolerated(0.49) | benign(0.018) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
C16orf89 | SNV | Missense_Mutation | rs537472512 | c.808N>T | p.Arg270Trp | p.R270W | Q6UX73 | protein_coding | tolerated(0.08) | possibly_damaging(0.791) | TCGA-CM-6167-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C16orf89 | SNV | Missense_Mutation | c.771N>A | p.Phe257Leu | p.F257L | Q6UX73 | protein_coding | tolerated(0.49) | benign(0.018) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C16orf89 | SNV | Missense_Mutation | rs537472512 | c.808N>T | p.Arg270Trp | p.R270W | Q6UX73 | protein_coding | tolerated(0.08) | possibly_damaging(0.791) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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