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Gene: C16orf70 |
Gene summary for C16ORF70 |
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Gene information | Species | Human | Gene symbol | C16orf70 | Gene ID | 80262 |
Gene name | phagosome assembly factor 1 | |
Gene Alias | C16orf6 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R6W4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80262 | C16orf70 | LZE2T | Human | Esophagus | ESCC | 6.67e-03 | 3.35e-01 | 0.082 |
80262 | C16orf70 | LZE4T | Human | Esophagus | ESCC | 7.62e-05 | 1.65e-01 | 0.0811 |
80262 | C16orf70 | LZE20T | Human | Esophagus | ESCC | 4.60e-05 | 1.91e-01 | 0.0662 |
80262 | C16orf70 | LZE24T | Human | Esophagus | ESCC | 8.54e-15 | 3.45e-01 | 0.0596 |
80262 | C16orf70 | LZE21T | Human | Esophagus | ESCC | 1.20e-05 | 3.16e-01 | 0.0655 |
80262 | C16orf70 | P1T-E | Human | Esophagus | ESCC | 3.78e-06 | 2.85e-01 | 0.0875 |
80262 | C16orf70 | P2T-E | Human | Esophagus | ESCC | 3.52e-16 | 1.85e-01 | 0.1177 |
80262 | C16orf70 | P4T-E | Human | Esophagus | ESCC | 2.55e-15 | 3.30e-01 | 0.1323 |
80262 | C16orf70 | P5T-E | Human | Esophagus | ESCC | 1.01e-18 | 2.12e-01 | 0.1327 |
80262 | C16orf70 | P8T-E | Human | Esophagus | ESCC | 2.74e-10 | 2.10e-01 | 0.0889 |
80262 | C16orf70 | P9T-E | Human | Esophagus | ESCC | 1.29e-07 | 1.81e-01 | 0.1131 |
80262 | C16orf70 | P10T-E | Human | Esophagus | ESCC | 8.92e-08 | 1.47e-01 | 0.116 |
80262 | C16orf70 | P11T-E | Human | Esophagus | ESCC | 1.47e-09 | 4.13e-01 | 0.1426 |
80262 | C16orf70 | P12T-E | Human | Esophagus | ESCC | 8.91e-20 | 2.86e-01 | 0.1122 |
80262 | C16orf70 | P15T-E | Human | Esophagus | ESCC | 4.27e-17 | 3.73e-01 | 0.1149 |
80262 | C16orf70 | P16T-E | Human | Esophagus | ESCC | 2.27e-07 | 1.68e-01 | 0.1153 |
80262 | C16orf70 | P17T-E | Human | Esophagus | ESCC | 6.38e-03 | 1.94e-01 | 0.1278 |
80262 | C16orf70 | P19T-E | Human | Esophagus | ESCC | 3.38e-03 | 3.17e-01 | 0.1662 |
80262 | C16orf70 | P20T-E | Human | Esophagus | ESCC | 4.43e-20 | 4.10e-01 | 0.1124 |
80262 | C16orf70 | P21T-E | Human | Esophagus | ESCC | 9.71e-16 | 3.02e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C16orf70 | SNV | Missense_Mutation | novel | c.321N>C | p.Gln107His | p.Q107H | Q9BSU1 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
C16orf70 | SNV | Missense_Mutation | c.149N>G | p.Ser50Cys | p.S50C | Q9BSU1 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C16orf70 | SNV | Missense_Mutation | novel | c.1223N>C | p.Gly408Ala | p.G408A | Q9BSU1 | protein_coding | tolerated(0.49) | benign(0.038) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
C16orf70 | SNV | Missense_Mutation | novel | c.943N>T | p.Gly315Trp | p.G315W | Q9BSU1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
C16orf70 | SNV | Missense_Mutation | c.947A>G | p.His316Arg | p.H316R | Q9BSU1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C16orf70 | SNV | Missense_Mutation | c.131N>C | p.Val44Ala | p.V44A | Q9BSU1 | protein_coding | deleterious(0) | possibly_damaging(0.685) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C16orf70 | SNV | Missense_Mutation | c.1226N>T | p.Pro409Leu | p.P409L | Q9BSU1 | protein_coding | tolerated(0.17) | benign(0.037) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C16orf70 | SNV | Missense_Mutation | novel | c.862N>A | p.Tyr288Asn | p.Y288N | Q9BSU1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C16orf70 | deletion | Frame_Shift_Del | rs772858888 | c.853delN | p.Phe286LeufsTer19 | p.F286Lfs*19 | Q9BSU1 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
C16orf70 | SNV | Missense_Mutation | novel | c.1232N>T | p.Arg411Met | p.R411M | Q9BSU1 | protein_coding | tolerated(0.06) | possibly_damaging(0.496) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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