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Gene: C15orf57 |
Gene summary for C15ORF57 |
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Gene information | Species | Human | Gene symbol | C15orf57 | Gene ID | 90416 |
Gene name | coiled-coil domain containing 32 | |
Gene Alias | C15orf57 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9BV29 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90416 | C15orf57 | P1T-E | Human | Esophagus | ESCC | 1.45e-07 | 3.30e-01 | 0.0875 |
90416 | C15orf57 | P2T-E | Human | Esophagus | ESCC | 3.60e-19 | 2.37e-01 | 0.1177 |
90416 | C15orf57 | P4T-E | Human | Esophagus | ESCC | 7.26e-16 | 4.56e-01 | 0.1323 |
90416 | C15orf57 | P5T-E | Human | Esophagus | ESCC | 2.35e-11 | 2.04e-01 | 0.1327 |
90416 | C15orf57 | P8T-E | Human | Esophagus | ESCC | 5.46e-21 | 3.46e-01 | 0.0889 |
90416 | C15orf57 | P9T-E | Human | Esophagus | ESCC | 3.81e-16 | 3.39e-01 | 0.1131 |
90416 | C15orf57 | P10T-E | Human | Esophagus | ESCC | 2.78e-17 | 3.20e-01 | 0.116 |
90416 | C15orf57 | P11T-E | Human | Esophagus | ESCC | 9.40e-10 | 3.37e-01 | 0.1426 |
90416 | C15orf57 | P12T-E | Human | Esophagus | ESCC | 2.14e-17 | 3.50e-01 | 0.1122 |
90416 | C15orf57 | P15T-E | Human | Esophagus | ESCC | 1.62e-14 | 2.33e-01 | 0.1149 |
90416 | C15orf57 | P16T-E | Human | Esophagus | ESCC | 1.97e-24 | 3.18e-01 | 0.1153 |
90416 | C15orf57 | P19T-E | Human | Esophagus | ESCC | 1.32e-03 | 2.94e-01 | 0.1662 |
90416 | C15orf57 | P20T-E | Human | Esophagus | ESCC | 4.55e-13 | 2.56e-01 | 0.1124 |
90416 | C15orf57 | P21T-E | Human | Esophagus | ESCC | 3.30e-20 | 3.05e-01 | 0.1617 |
90416 | C15orf57 | P22T-E | Human | Esophagus | ESCC | 2.75e-25 | 3.66e-01 | 0.1236 |
90416 | C15orf57 | P23T-E | Human | Esophagus | ESCC | 6.28e-18 | 3.86e-01 | 0.108 |
90416 | C15orf57 | P24T-E | Human | Esophagus | ESCC | 1.04e-12 | 2.63e-01 | 0.1287 |
90416 | C15orf57 | P26T-E | Human | Esophagus | ESCC | 3.37e-26 | 4.14e-01 | 0.1276 |
90416 | C15orf57 | P27T-E | Human | Esophagus | ESCC | 1.72e-06 | 1.88e-01 | 0.1055 |
90416 | C15orf57 | P28T-E | Human | Esophagus | ESCC | 5.00e-14 | 1.76e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C15orf57 | insertion | Nonsense_Mutation | novel | c.17_18insGGAGAATTGATGTTTCTCATGAAATGGAAAGATTCAGATGAGG | p.Arg7GlufsTer3 | p.R7Efs*3 | Q9BV29 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
C15orf57 | SNV | Missense_Mutation | rs139886034 | c.332G>A | p.Arg111Gln | p.R111Q | Q9BV29 | protein_coding | tolerated(0.15) | benign(0.049) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
C15orf57 | SNV | Missense_Mutation | c.152N>T | p.Ser51Phe | p.S51F | Q9BV29 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C15orf57 | SNV | Missense_Mutation | novel | c.164N>A | p.Ser55Tyr | p.S55Y | Q9BV29 | protein_coding | deleterious(0.02) | possibly_damaging(0.804) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C15orf57 | SNV | Missense_Mutation | novel | c.30G>T | p.Met10Ile | p.M10I | Q9BV29 | protein_coding | deleterious_low_confidence(0) | benign(0.05) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C15orf57 | SNV | Missense_Mutation | novel | c.250G>A | p.Glu84Lys | p.E84K | Q9BV29 | protein_coding | deleterious(0.01) | possibly_damaging(0.889) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C15orf57 | SNV | Missense_Mutation | rs139886034 | c.332N>A | p.Arg111Gln | p.R111Q | Q9BV29 | protein_coding | tolerated(0.15) | benign(0.049) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C15orf57 | SNV | Missense_Mutation | c.27A>T | p.Gln9His | p.Q9H | Q9BV29 | protein_coding | deleterious_low_confidence(0.04) | benign(0.005) | TCGA-55-7727-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C15orf57 | SNV | Missense_Mutation | c.94T>C | p.Cys32Arg | p.C32R | Q9BV29 | protein_coding | deleterious(0) | possibly_damaging(0.734) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C15orf57 | SNV | Missense_Mutation | novel | c.278N>T | p.Lys93Met | p.K93M | Q9BV29 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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