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Gene: C15orf40 |
Gene summary for C15ORF40 |
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Gene information | Species | Human | Gene symbol | C15orf40 | Gene ID | 123207 |
Gene name | chromosome 15 open reading frame 40 | |
Gene Alias | C15orf40 | |
Cytomap | 15q25.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WUR7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123207 | C15orf40 | LZE2T | Human | Esophagus | ESCC | 2.39e-03 | 8.86e-01 | 0.082 |
123207 | C15orf40 | LZE4T | Human | Esophagus | ESCC | 1.32e-17 | 5.95e-01 | 0.0811 |
123207 | C15orf40 | LZE5T | Human | Esophagus | ESCC | 2.08e-03 | 3.61e-01 | 0.0514 |
123207 | C15orf40 | LZE7T | Human | Esophagus | ESCC | 3.73e-21 | 8.78e-01 | 0.0667 |
123207 | C15orf40 | LZE8T | Human | Esophagus | ESCC | 2.26e-07 | 2.68e-01 | 0.067 |
123207 | C15orf40 | LZE20T | Human | Esophagus | ESCC | 2.05e-02 | 1.82e-01 | 0.0662 |
123207 | C15orf40 | LZE22T | Human | Esophagus | ESCC | 5.04e-05 | 5.73e-01 | 0.068 |
123207 | C15orf40 | LZE24T | Human | Esophagus | ESCC | 8.28e-18 | 4.60e-01 | 0.0596 |
123207 | C15orf40 | LZE21T | Human | Esophagus | ESCC | 2.82e-06 | 4.87e-01 | 0.0655 |
123207 | C15orf40 | LZE6T | Human | Esophagus | ESCC | 4.71e-02 | 3.31e-01 | 0.0845 |
123207 | C15orf40 | P1T-E | Human | Esophagus | ESCC | 1.02e-20 | 1.06e+00 | 0.0875 |
123207 | C15orf40 | P2T-E | Human | Esophagus | ESCC | 1.86e-52 | 8.92e-01 | 0.1177 |
123207 | C15orf40 | P4T-E | Human | Esophagus | ESCC | 7.53e-45 | 1.11e+00 | 0.1323 |
123207 | C15orf40 | P5T-E | Human | Esophagus | ESCC | 9.87e-27 | 3.05e-01 | 0.1327 |
123207 | C15orf40 | P8T-E | Human | Esophagus | ESCC | 1.02e-23 | 5.14e-01 | 0.0889 |
123207 | C15orf40 | P9T-E | Human | Esophagus | ESCC | 1.24e-30 | 7.46e-01 | 0.1131 |
123207 | C15orf40 | P10T-E | Human | Esophagus | ESCC | 2.56e-38 | 6.04e-01 | 0.116 |
123207 | C15orf40 | P11T-E | Human | Esophagus | ESCC | 1.10e-11 | 4.11e-01 | 0.1426 |
123207 | C15orf40 | P12T-E | Human | Esophagus | ESCC | 6.14e-27 | 5.20e-01 | 0.1122 |
123207 | C15orf40 | P15T-E | Human | Esophagus | ESCC | 9.63e-56 | 1.06e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C15orf40 | SNV | Missense_Mutation | c.345G>C | p.Lys115Asn | p.K115N | Q8WUR7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C15orf40 | SNV | Missense_Mutation | novel | c.126N>A | p.Ser42Arg | p.S42R | Q8WUR7 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
C15orf40 | SNV | Missense_Mutation | c.345N>T | p.Lys115Asn | p.K115N | Q8WUR7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C15orf40 | deletion | Frame_Shift_Del | novel | c.62delN | p.Ala21ValfsTer32 | p.A21Vfs*32 | Q8WUR7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
C15orf40 | insertion | Frame_Shift_Ins | novel | c.276_277insG | p.Pro93AlafsTer8 | p.P93Afs*8 | Q8WUR7 | protein_coding | TCGA-AX-A062-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C15orf40 | insertion | Nonsense_Mutation | novel | c.275_276insGCTGGGATTAGAGGTATG | p.Ala92_Pro93insLeuGlyLeuGluValTer | p.A92_P93insLGLEV* | Q8WUR7 | protein_coding | TCGA-AX-A062-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C15orf40 | SNV | Missense_Mutation | c.172N>A | p.Asp58Asn | p.D58N | Q8WUR7 | protein_coding | tolerated(0.06) | benign(0.155) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD | |
C15orf40 | SNV | Missense_Mutation | novel | c.342N>T | p.Arg114Ser | p.R114S | Q8WUR7 | protein_coding | deleterious(0.04) | possibly_damaging(0.623) | TCGA-85-8350-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C15orf40 | SNV | Missense_Mutation | novel | c.310T>C | p.Cys104Arg | p.C104R | Q8WUR7 | protein_coding | deleterious(0) | possibly_damaging(0.831) | TCGA-ZG-A9LZ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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