|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: C14orf2 |
Gene summary for C14ORF2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C14orf2 | Gene ID | 9556 |
| Gene name | ATP synthase membrane subunit j | |
| Gene Alias | 6.8PL | |
| Cytomap | 14q32.33 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R6N3 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9556 | C14orf2 | GSM4909280 | Human | Breast | Precancer | 4.76e-02 | -3.58e-01 | 0.0305 |
| 9556 | C14orf2 | GSM4909281 | Human | Breast | IDC | 1.08e-15 | -3.58e-01 | 0.21 |
| 9556 | C14orf2 | GSM4909282 | Human | Breast | IDC | 1.37e-13 | -3.58e-01 | -0.0288 |
| 9556 | C14orf2 | GSM4909285 | Human | Breast | IDC | 1.23e-14 | -3.58e-01 | 0.21 |
| 9556 | C14orf2 | GSM4909286 | Human | Breast | IDC | 4.80e-16 | -3.58e-01 | 0.1081 |
| 9556 | C14orf2 | GSM4909287 | Human | Breast | IDC | 1.15e-21 | -3.58e-01 | 0.2057 |
| 9556 | C14orf2 | GSM4909288 | Human | Breast | IDC | 4.73e-05 | -3.58e-01 | 0.0988 |
| 9556 | C14orf2 | GSM4909289 | Human | Breast | IDC | 1.76e-03 | -3.58e-01 | 0.1064 |
| 9556 | C14orf2 | GSM4909290 | Human | Breast | IDC | 1.58e-15 | -3.58e-01 | 0.2096 |
| 9556 | C14orf2 | GSM4909291 | Human | Breast | IDC | 1.39e-12 | -3.58e-01 | 0.1753 |
| 9556 | C14orf2 | GSM4909293 | Human | Breast | IDC | 2.75e-14 | -3.58e-01 | 0.1581 |
| 9556 | C14orf2 | GSM4909294 | Human | Breast | IDC | 1.08e-15 | -3.58e-01 | 0.2022 |
| 9556 | C14orf2 | GSM4909295 | Human | Breast | IDC | 6.99e-10 | -3.58e-01 | 0.0898 |
| 9556 | C14orf2 | GSM4909296 | Human | Breast | IDC | 5.48e-15 | -3.58e-01 | 0.1524 |
| 9556 | C14orf2 | GSM4909297 | Human | Breast | IDC | 9.36e-17 | -3.58e-01 | 0.1517 |
| 9556 | C14orf2 | GSM4909298 | Human | Breast | IDC | 5.48e-15 | -3.58e-01 | 0.1551 |
| 9556 | C14orf2 | GSM4909299 | Human | Breast | IDC | 2.44e-15 | -3.58e-01 | 0.035 |
| 9556 | C14orf2 | GSM4909300 | Human | Breast | IDC | 1.02e-08 | -3.58e-01 | 0.0334 |
| 9556 | C14orf2 | GSM4909301 | Human | Breast | IDC | 1.08e-15 | -3.58e-01 | 0.1577 |
| 9556 | C14orf2 | GSM4909302 | Human | Breast | IDC | 2.34e-21 | -3.58e-01 | 0.1545 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C14orf2 | SNV | Missense_Mutation | rs749080256 | c.154N>A | p.Val52Ile | p.V52I | P56378 | protein_coding | tolerated(0.38) | benign(0.107) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
| C14orf2 | SNV | Missense_Mutation | c.182N>T | p.Arg61Ile | p.R61I | P56378 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| C14orf2 | SNV | Missense_Mutation | c.42N>G | p.Phe14Leu | p.F14L | P56378 | protein_coding | tolerated_low_confidence(0.73) | benign(0) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
| C14orf2 | SNV | Missense_Mutation | novel | c.136G>T | p.Gly46Trp | p.G46W | P56378 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C14orf2 | SNV | Missense_Mutation | novel | c.101N>C | p.Tyr34Ser | p.Y34S | P56378 | protein_coding | tolerated(0.08) | possibly_damaging(0.747) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| C14orf2 | SNV | Missense_Mutation | novel | c.83N>G | p.Ile28Ser | p.I28S | P56378 | protein_coding | tolerated(0.25) | benign(0.373) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |