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Gene: C12orf73 |
Gene summary for C12ORF73 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C12orf73 | Gene ID | 728568 |
| Gene name | chromosome 12 open reading frame 73 | |
| Gene Alias | BR | |
| Cytomap | 12q23.3 | |
| Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q69YU5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 728568 | C12orf73 | LZE4T | Human | Esophagus | ESCC | 1.11e-03 | 1.66e-01 | 0.0811 |
| 728568 | C12orf73 | LZE7T | Human | Esophagus | ESCC | 1.53e-09 | 6.49e-01 | 0.0667 |
| 728568 | C12orf73 | LZE24T | Human | Esophagus | ESCC | 1.38e-07 | 2.62e-01 | 0.0596 |
| 728568 | C12orf73 | P1T-E | Human | Esophagus | ESCC | 1.56e-04 | 2.77e-01 | 0.0875 |
| 728568 | C12orf73 | P2T-E | Human | Esophagus | ESCC | 8.04e-27 | 5.55e-01 | 0.1177 |
| 728568 | C12orf73 | P4T-E | Human | Esophagus | ESCC | 2.87e-25 | 5.48e-01 | 0.1323 |
| 728568 | C12orf73 | P5T-E | Human | Esophagus | ESCC | 2.11e-10 | 2.66e-01 | 0.1327 |
| 728568 | C12orf73 | P8T-E | Human | Esophagus | ESCC | 4.06e-12 | 2.37e-01 | 0.0889 |
| 728568 | C12orf73 | P9T-E | Human | Esophagus | ESCC | 9.05e-08 | 1.65e-01 | 0.1131 |
| 728568 | C12orf73 | P10T-E | Human | Esophagus | ESCC | 7.07e-23 | 4.42e-01 | 0.116 |
| 728568 | C12orf73 | P11T-E | Human | Esophagus | ESCC | 9.31e-12 | 3.26e-01 | 0.1426 |
| 728568 | C12orf73 | P12T-E | Human | Esophagus | ESCC | 1.03e-17 | 4.26e-01 | 0.1122 |
| 728568 | C12orf73 | P15T-E | Human | Esophagus | ESCC | 1.59e-17 | 3.30e-01 | 0.1149 |
| 728568 | C12orf73 | P16T-E | Human | Esophagus | ESCC | 1.47e-21 | 4.20e-01 | 0.1153 |
| 728568 | C12orf73 | P17T-E | Human | Esophagus | ESCC | 2.70e-04 | 2.17e-01 | 0.1278 |
| 728568 | C12orf73 | P19T-E | Human | Esophagus | ESCC | 5.15e-07 | 4.26e-01 | 0.1662 |
| 728568 | C12orf73 | P20T-E | Human | Esophagus | ESCC | 1.87e-12 | 3.32e-01 | 0.1124 |
| 728568 | C12orf73 | P21T-E | Human | Esophagus | ESCC | 5.50e-14 | 2.63e-01 | 0.1617 |
| 728568 | C12orf73 | P22T-E | Human | Esophagus | ESCC | 1.28e-25 | 4.81e-01 | 0.1236 |
| 728568 | C12orf73 | P23T-E | Human | Esophagus | ESCC | 6.03e-16 | 3.77e-01 | 0.108 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
| GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
| GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
| GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
| GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
| GO:00170043 | Oral cavity | OSCC | cytochrome complex assembly | 31/7305 | 36/18723 | 7.28e-09 | 1.53e-07 | 31 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C12orf73 | SNV | Missense_Mutation | c.50N>A | p.Ser17Asn | p.S17N | Q69YU5 | protein_coding | deleterious(0.04) | possibly_damaging(0.691) | TCGA-F4-6569-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
| C12orf73 | SNV | Missense_Mutation | novel | c.32N>C | p.Leu11Pro | p.L11P | Q69YU5 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C12orf73 | SNV | Missense_Mutation | c.209N>G | p.Leu70Arg | p.L70R | Q69YU5 | protein_coding | deleterious_low_confidence(0) | benign(0.158) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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