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Gene: C12orf45 |
Gene summary for C12ORF45 |
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Gene information | Species | Human | Gene symbol | C12orf45 | Gene ID | 121053 |
Gene name | NOP protein chaperone 1 | |
Gene Alias | C12orf45 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000491 | UniProtAcc | Q8N5I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121053 | C12orf45 | LZE4T | Human | Esophagus | ESCC | 5.01e-09 | 6.58e-02 | 0.0811 |
121053 | C12orf45 | LZE5T | Human | Esophagus | ESCC | 9.69e-03 | 1.04e-01 | 0.0514 |
121053 | C12orf45 | LZE7T | Human | Esophagus | ESCC | 6.21e-08 | 3.74e-01 | 0.0667 |
121053 | C12orf45 | LZE8T | Human | Esophagus | ESCC | 2.26e-03 | 2.44e-02 | 0.067 |
121053 | C12orf45 | LZE20T | Human | Esophagus | ESCC | 1.01e-06 | 2.12e-02 | 0.0662 |
121053 | C12orf45 | LZE22D1 | Human | Esophagus | HGIN | 7.70e-05 | 7.97e-02 | 0.0595 |
121053 | C12orf45 | LZE22T | Human | Esophagus | ESCC | 4.05e-05 | 2.13e-01 | 0.068 |
121053 | C12orf45 | LZE24T | Human | Esophagus | ESCC | 2.17e-11 | 2.57e-01 | 0.0596 |
121053 | C12orf45 | LZE21T | Human | Esophagus | ESCC | 1.33e-03 | 2.53e-01 | 0.0655 |
121053 | C12orf45 | LZE6T | Human | Esophagus | ESCC | 1.87e-02 | 1.49e-01 | 0.0845 |
121053 | C12orf45 | P1T-E | Human | Esophagus | ESCC | 1.02e-05 | 2.06e-01 | 0.0875 |
121053 | C12orf45 | P2T-E | Human | Esophagus | ESCC | 4.62e-37 | 7.64e-01 | 0.1177 |
121053 | C12orf45 | P4T-E | Human | Esophagus | ESCC | 5.50e-25 | 7.11e-01 | 0.1323 |
121053 | C12orf45 | P5T-E | Human | Esophagus | ESCC | 2.32e-21 | 5.79e-01 | 0.1327 |
121053 | C12orf45 | P8T-E | Human | Esophagus | ESCC | 8.54e-08 | 3.01e-01 | 0.0889 |
121053 | C12orf45 | P9T-E | Human | Esophagus | ESCC | 6.86e-14 | 1.68e-01 | 0.1131 |
121053 | C12orf45 | P10T-E | Human | Esophagus | ESCC | 2.08e-14 | 3.30e-01 | 0.116 |
121053 | C12orf45 | P11T-E | Human | Esophagus | ESCC | 3.76e-05 | 2.52e-01 | 0.1426 |
121053 | C12orf45 | P12T-E | Human | Esophagus | ESCC | 5.99e-17 | 2.47e-01 | 0.1122 |
121053 | C12orf45 | P15T-E | Human | Esophagus | ESCC | 1.31e-18 | 4.90e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C12orf45 | SNV | Missense_Mutation | rs371639910 | c.29G>A | p.Ser10Asn | p.S10N | Q8N5I9 | protein_coding | tolerated_low_confidence(0.38) | benign(0) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
C12orf45 | SNV | Missense_Mutation | c.497N>T | p.Ser166Phe | p.S166F | Q8N5I9 | protein_coding | deleterious(0) | possibly_damaging(0.748) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C12orf45 | SNV | Missense_Mutation | rs748939881 | c.184C>T | p.Arg62Trp | p.R62W | Q8N5I9 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C12orf45 | SNV | Missense_Mutation | c.420N>T | p.Glu140Asp | p.E140D | Q8N5I9 | protein_coding | tolerated(0.25) | benign(0.012) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C12orf45 | SNV | Missense_Mutation | c.196A>G | p.Ser66Gly | p.S66G | Q8N5I9 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C12orf45 | insertion | Nonsense_Mutation | novel | c.327_328insTTCTGAAACCCAG | p.Val110PhefsTer2 | p.V110Ffs*2 | Q8N5I9 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C12orf45 | SNV | Missense_Mutation | novel | c.238G>A | p.Ala80Thr | p.A80T | Q8N5I9 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
C12orf45 | insertion | Frame_Shift_Ins | rs777032057 | c.543_544insA | p.Lys185GlufsTer5 | p.K185Efs*5 | Q8N5I9 | protein_coding | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C12orf45 | insertion | Frame_Shift_Ins | rs777032057 | c.543_544insA | p.Lys185GlufsTer5 | p.K185Efs*5 | Q8N5I9 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C12orf45 | SNV | Missense_Mutation | c.486N>T | p.Lys162Asn | p.K162N | Q8N5I9 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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