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Gene: C12orf23 |
Gene summary for C12ORF23 |
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Gene information | Species | Human | Gene symbol | C12orf23 | Gene ID | 90488 |
Gene name | transmembrane protein 263 | |
Gene Alias | C12orf23 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WUH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90488 | C12orf23 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.29e-04 | 5.32e-01 | 0.159 |
90488 | C12orf23 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 3.54e-05 | 5.81e-01 | 0.1479 |
90488 | C12orf23 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 6.16e-12 | 4.47e-01 | 0.1633 |
90488 | C12orf23 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 6.49e-15 | 4.98e-01 | 0.1608 |
90488 | C12orf23 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.46e-02 | 1.95e-01 | 0.1604 |
90488 | C12orf23 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.24e-08 | 3.44e-01 | 0.1621 |
90488 | C12orf23 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.27e-04 | 4.06e-01 | 0.1619 |
90488 | C12orf23 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.14e-06 | 5.73e-01 | 0.159 |
90488 | C12orf23 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.07e-09 | 4.64e-01 | 0.1602 |
90488 | C12orf23 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.51e-03 | 2.74e-01 | 0.1608 |
90488 | C12orf23 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 2.91e-04 | 4.27e-01 | 0.1622 |
90488 | C12orf23 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.52e-04 | 2.17e-01 | 0.1575 |
90488 | C12orf23 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.82e-02 | 2.37e-01 | 0.1545 |
90488 | C12orf23 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 2.28e-02 | 1.79e-01 | 0.1569 |
90488 | C12orf23 | P4_cSCC | Human | Skin | cSCC | 2.51e-02 | 6.95e-02 | -0.00290000000000005 |
90488 | C12orf23 | P10_cSCC | Human | Skin | cSCC | 9.88e-18 | 4.82e-01 | 0.1017 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
Skin | ![]() | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma | ||
SCCIS:squamous cell carcinoma in situ |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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