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Gene: C12orf10 |
Gene summary for C12ORF10 |
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Gene information | Species | Human | Gene symbol | C12orf10 | Gene ID | 60314 |
Gene name | MYG1 exonuclease | |
Gene Alias | C12orf10 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86UA3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60314 | C12orf10 | LZE4T | Human | Esophagus | ESCC | 6.17e-04 | 1.38e-01 | 0.0811 |
60314 | C12orf10 | LZE7T | Human | Esophagus | ESCC | 7.61e-12 | 6.17e-01 | 0.0667 |
60314 | C12orf10 | LZE8T | Human | Esophagus | ESCC | 6.14e-07 | 2.44e-01 | 0.067 |
60314 | C12orf10 | LZE20T | Human | Esophagus | ESCC | 1.49e-04 | 1.80e-01 | 0.0662 |
60314 | C12orf10 | LZE22D1 | Human | Esophagus | HGIN | 1.06e-02 | 1.94e-01 | 0.0595 |
60314 | C12orf10 | LZE22T | Human | Esophagus | ESCC | 5.35e-03 | 3.34e-01 | 0.068 |
60314 | C12orf10 | LZE24T | Human | Esophagus | ESCC | 6.27e-21 | 6.74e-01 | 0.0596 |
60314 | C12orf10 | LZE21T | Human | Esophagus | ESCC | 2.12e-04 | 4.53e-01 | 0.0655 |
60314 | C12orf10 | LZE6T | Human | Esophagus | ESCC | 8.99e-03 | 1.64e-01 | 0.0845 |
60314 | C12orf10 | P1T-E | Human | Esophagus | ESCC | 4.82e-10 | 5.24e-01 | 0.0875 |
60314 | C12orf10 | P2T-E | Human | Esophagus | ESCC | 6.86e-46 | 8.71e-01 | 0.1177 |
60314 | C12orf10 | P4T-E | Human | Esophagus | ESCC | 3.08e-28 | 7.05e-01 | 0.1323 |
60314 | C12orf10 | P5T-E | Human | Esophagus | ESCC | 2.17e-34 | 6.85e-01 | 0.1327 |
60314 | C12orf10 | P8T-E | Human | Esophagus | ESCC | 7.42e-29 | 6.09e-01 | 0.0889 |
60314 | C12orf10 | P9T-E | Human | Esophagus | ESCC | 4.03e-19 | 4.20e-01 | 0.1131 |
60314 | C12orf10 | P10T-E | Human | Esophagus | ESCC | 2.05e-27 | 4.70e-01 | 0.116 |
60314 | C12orf10 | P11T-E | Human | Esophagus | ESCC | 5.64e-17 | 6.55e-01 | 0.1426 |
60314 | C12orf10 | P12T-E | Human | Esophagus | ESCC | 2.81e-23 | 5.18e-01 | 0.1122 |
60314 | C12orf10 | P15T-E | Human | Esophagus | ESCC | 3.06e-38 | 7.72e-01 | 0.1149 |
60314 | C12orf10 | P16T-E | Human | Esophagus | ESCC | 5.68e-35 | 7.95e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C12orf10 | deletion | Frame_Shift_Del | novel | c.418delN | p.His141ThrfsTer51 | p.H141Tfs*51 | Q9HB07 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C12orf10 | SNV | Missense_Mutation | rs778692195 | c.295G>A | p.Asp99Asn | p.D99N | Q9HB07 | protein_coding | deleterious(0.03) | benign(0.333) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C12orf10 | SNV | Missense_Mutation | c.704A>G | p.Tyr235Cys | p.Y235C | Q9HB07 | protein_coding | deleterious(0) | benign(0.416) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
C12orf10 | SNV | Missense_Mutation | c.316N>A | p.Asp106Asn | p.D106N | Q9HB07 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C12orf10 | SNV | Missense_Mutation | novel | c.1040G>A | p.Gly347Asp | p.G347D | Q9HB07 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C12orf10 | SNV | Missense_Mutation | c.1033N>A | p.Ala345Thr | p.A345T | Q9HB07 | protein_coding | tolerated(0.09) | benign(0.078) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C12orf10 | SNV | Missense_Mutation | rs202213306 | c.970N>T | p.Arg324Trp | p.R324W | Q9HB07 | protein_coding | deleterious(0.01) | possibly_damaging(0.839) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
C12orf10 | SNV | Missense_Mutation | c.713N>A | p.Ser238Asn | p.S238N | Q9HB07 | protein_coding | deleterious(0.01) | possibly_damaging(0.542) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
C12orf10 | SNV | Missense_Mutation | rs138116397 | c.1088N>A | p.Arg363His | p.R363H | Q9HB07 | protein_coding | deleterious(0.02) | possibly_damaging(0.594) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C12orf10 | SNV | Missense_Mutation | rs142439022 | c.395C>T | p.Ala132Val | p.A132V | Q9HB07 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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