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Gene: C11orf96 |
Gene summary for C11ORF96 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C11orf96 | Gene ID | 387763 |
| Gene name | chromosome 11 open reading frame 96 | |
| Gene Alias | AG2 | |
| Cytomap | 11p11.2 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A087WW59 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 387763 | C11orf96 | sample1 | Human | Cervix | CC | 1.01e-08 | 5.02e-01 | 0.0959 |
| 387763 | C11orf96 | T1 | Human | Cervix | CC | 1.06e-15 | 5.01e-01 | 0.0918 |
| 387763 | C11orf96 | T2 | Human | Cervix | CC | 7.99e-03 | 2.46e-01 | 0.0709 |
| 387763 | C11orf96 | AEH-subject3 | Human | Endometrium | AEH | 4.60e-10 | -4.20e-01 | -0.2576 |
| 387763 | C11orf96 | AEH-subject5 | Human | Endometrium | AEH | 7.72e-13 | -4.67e-01 | -0.2953 |
| 387763 | C11orf96 | EEC-subject1 | Human | Endometrium | EEC | 4.54e-06 | -4.07e-01 | -0.2682 |
| 387763 | C11orf96 | EEC-subject2 | Human | Endometrium | EEC | 4.76e-07 | -3.78e-01 | -0.2607 |
| 387763 | C11orf96 | EEC-subject3 | Human | Endometrium | EEC | 7.05e-08 | -9.15e-02 | -0.2525 |
| 387763 | C11orf96 | EEC-subject4 | Human | Endometrium | EEC | 2.63e-04 | -3.38e-01 | -0.2571 |
| 387763 | C11orf96 | EEC-subject5 | Human | Endometrium | EEC | 1.52e-16 | -4.70e-01 | -0.249 |
| 387763 | C11orf96 | GSM5276934 | Human | Endometrium | EEC | 8.02e-79 | 1.44e+00 | -0.0913 |
| 387763 | C11orf96 | GSM5276935 | Human | Endometrium | EEC | 4.44e-07 | -3.92e-01 | -0.123 |
| 387763 | C11orf96 | GSM5276937 | Human | Endometrium | EEC | 2.21e-51 | 1.29e+00 | -0.0897 |
| 387763 | C11orf96 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.34e-18 | -5.27e-01 | -0.1869 |
| 387763 | C11orf96 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.14e-16 | -5.27e-01 | -0.1875 |
| 387763 | C11orf96 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 7.09e-19 | -5.27e-01 | -0.1883 |
| 387763 | C11orf96 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.69e-20 | -5.19e-01 | -0.1934 |
| 387763 | C11orf96 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.28e-25 | -5.27e-01 | -0.1917 |
| 387763 | C11orf96 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.10e-21 | -5.17e-01 | -0.1916 |
| 387763 | C11orf96 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.03e-18 | -4.87e-01 | -0.1269 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C11orf96 | deletion | Frame_Shift_Del | c.207delN | p.Val71CysfsTer39 | p.V71Cfs*39 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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