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Gene: C11orf86 |
Gene summary for C11ORF86 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C11orf86 | Gene ID | 254439 |
| Gene name | chromosome 11 open reading frame 86 | |
| Gene Alias | C11orf86 | |
| Cytomap | 11q13.2 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6NJI1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 254439 | C11orf86 | Pat01-B | Human | Stomach | GC | 4.52e-56 | 9.56e-01 | 0.5754 |
| 254439 | C11orf86 | Pat02-B | Human | Stomach | GC | 8.23e-12 | 3.17e-01 | 0.0368 |
| 254439 | C11orf86 | Pat03-B | Human | Stomach | GC | 2.15e-29 | 6.65e-01 | 0.3693 |
| 254439 | C11orf86 | Pat05-B | Human | Stomach | GC | 1.21e-02 | 2.17e-01 | -0.0353 |
| 254439 | C11orf86 | Pat12-B | Human | Stomach | GC | 2.95e-05 | 2.10e-01 | 0.0325 |
| 254439 | C11orf86 | Pat16-B | Human | Stomach | GC | 7.93e-03 | 1.80e-01 | 0.1918 |
| 254439 | C11orf86 | Pat17-B | Human | Stomach | GC | 6.74e-23 | 6.77e-01 | 0.3109 |
| 254439 | C11orf86 | Pat19-B | Human | Stomach | GC | 3.24e-02 | 1.50e-01 | 0.0826 |
| 254439 | C11orf86 | WIM_2 | Human | Stomach | WIM | 5.88e-04 | 3.30e-01 | 0.1159 |
| 254439 | C11orf86 | SIM_1 | Human | Stomach | SIM | 1.71e-18 | 6.43e-01 | 0.3573 |
| 254439 | C11orf86 | SIM_2 | Human | Stomach | SIM | 2.02e-07 | 3.28e-01 | 0.3139 |
| 254439 | C11orf86 | SIM_4 | Human | Stomach | SIM | 2.71e-18 | 6.42e-01 | 0.2664 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C11orf86 | SNV | Missense_Mutation | novel | c.34N>A | p.Glu12Lys | p.E12K | A6NJI1 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-BH-A42U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| C11orf86 | SNV | Missense_Mutation | c.344C>A | p.Pro115Gln | p.P115Q | A6NJI1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.584) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| C11orf86 | SNV | Missense_Mutation | c.205C>A | p.Leu69Met | p.L69M | A6NJI1 | protein_coding | tolerated(0.13) | probably_damaging(0.948) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| C11orf86 | SNV | Missense_Mutation | rs537754545 | c.67N>A | p.Pro23Thr | p.P23T | A6NJI1 | protein_coding | tolerated(0.15) | benign(0.081) | TCGA-NH-A50U-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | PD |
| C11orf86 | SNV | Missense_Mutation | novel | c.292N>A | p.Glu98Lys | p.E98K | A6NJI1 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| C11orf86 | SNV | Missense_Mutation | c.233C>T | p.Ala78Val | p.A78V | A6NJI1 | protein_coding | tolerated(0.09) | benign(0.031) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| C11orf86 | SNV | Missense_Mutation | rs764298165 | c.41N>A | p.Arg14Gln | p.R14Q | A6NJI1 | protein_coding | tolerated(0.17) | benign(0.048) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| C11orf86 | SNV | Missense_Mutation | rs765750611 | c.32N>A | p.Arg11Gln | p.R11Q | A6NJI1 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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