![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C11orf86 |
Gene summary for C11ORF86 |
![]() |
Gene information | Species | Human | Gene symbol | C11orf86 | Gene ID | 254439 |
Gene name | chromosome 11 open reading frame 86 | |
Gene Alias | C11orf86 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6NJI1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254439 | C11orf86 | Pat01-B | Human | Stomach | GC | 4.52e-56 | 9.56e-01 | 0.5754 |
254439 | C11orf86 | Pat02-B | Human | Stomach | GC | 8.23e-12 | 3.17e-01 | 0.0368 |
254439 | C11orf86 | Pat03-B | Human | Stomach | GC | 2.15e-29 | 6.65e-01 | 0.3693 |
254439 | C11orf86 | Pat05-B | Human | Stomach | GC | 1.21e-02 | 2.17e-01 | -0.0353 |
254439 | C11orf86 | Pat12-B | Human | Stomach | GC | 2.95e-05 | 2.10e-01 | 0.0325 |
254439 | C11orf86 | Pat16-B | Human | Stomach | GC | 7.93e-03 | 1.80e-01 | 0.1918 |
254439 | C11orf86 | Pat17-B | Human | Stomach | GC | 6.74e-23 | 6.77e-01 | 0.3109 |
254439 | C11orf86 | Pat19-B | Human | Stomach | GC | 3.24e-02 | 1.50e-01 | 0.0826 |
254439 | C11orf86 | WIM_2 | Human | Stomach | WIM | 5.88e-04 | 3.30e-01 | 0.1159 |
254439 | C11orf86 | SIM_1 | Human | Stomach | SIM | 1.71e-18 | 6.43e-01 | 0.3573 |
254439 | C11orf86 | SIM_2 | Human | Stomach | SIM | 2.02e-07 | 3.28e-01 | 0.3139 |
254439 | C11orf86 | SIM_4 | Human | Stomach | SIM | 2.71e-18 | 6.42e-01 | 0.2664 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C11orf86 | SNV | Missense_Mutation | novel | c.34N>A | p.Glu12Lys | p.E12K | A6NJI1 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-BH-A42U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C11orf86 | SNV | Missense_Mutation | c.344C>A | p.Pro115Gln | p.P115Q | A6NJI1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.584) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
C11orf86 | SNV | Missense_Mutation | c.205C>A | p.Leu69Met | p.L69M | A6NJI1 | protein_coding | tolerated(0.13) | probably_damaging(0.948) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C11orf86 | SNV | Missense_Mutation | rs537754545 | c.67N>A | p.Pro23Thr | p.P23T | A6NJI1 | protein_coding | tolerated(0.15) | benign(0.081) | TCGA-NH-A50U-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | PD |
C11orf86 | SNV | Missense_Mutation | novel | c.292N>A | p.Glu98Lys | p.E98K | A6NJI1 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C11orf86 | SNV | Missense_Mutation | c.233C>T | p.Ala78Val | p.A78V | A6NJI1 | protein_coding | tolerated(0.09) | benign(0.031) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C11orf86 | SNV | Missense_Mutation | rs764298165 | c.41N>A | p.Arg14Gln | p.R14Q | A6NJI1 | protein_coding | tolerated(0.17) | benign(0.048) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C11orf86 | SNV | Missense_Mutation | rs765750611 | c.32N>A | p.Arg11Gln | p.R11Q | A6NJI1 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |