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Gene: C11orf1 |
Gene summary for C11ORF1 |
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Gene information | Species | Human | Gene symbol | C11orf1 | Gene ID | 64776 |
Gene name | chromosome 11 open reading frame 1 | |
Gene Alias | C11orf1 | |
Cytomap | 11q23.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | E9PS93 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64776 | C11orf1 | LZE4T | Human | Esophagus | ESCC | 2.04e-07 | -5.14e-02 | 0.0811 |
64776 | C11orf1 | LZE7T | Human | Esophagus | ESCC | 1.55e-10 | 1.19e-01 | 0.0667 |
64776 | C11orf1 | LZE8T | Human | Esophagus | ESCC | 6.85e-09 | -9.37e-03 | 0.067 |
64776 | C11orf1 | LZE20T | Human | Esophagus | ESCC | 4.86e-04 | 5.80e-02 | 0.0662 |
64776 | C11orf1 | LZE24T | Human | Esophagus | ESCC | 2.14e-11 | 4.49e-01 | 0.0596 |
64776 | C11orf1 | LZE21T | Human | Esophagus | ESCC | 2.04e-04 | 1.29e-02 | 0.0655 |
64776 | C11orf1 | LZE6T | Human | Esophagus | ESCC | 2.61e-03 | -1.25e-01 | 0.0845 |
64776 | C11orf1 | P1T-E | Human | Esophagus | ESCC | 1.06e-04 | 1.36e-02 | 0.0875 |
64776 | C11orf1 | P2T-E | Human | Esophagus | ESCC | 1.19e-16 | 2.88e-01 | 0.1177 |
64776 | C11orf1 | P4T-E | Human | Esophagus | ESCC | 1.58e-24 | 9.03e-01 | 0.1323 |
64776 | C11orf1 | P5T-E | Human | Esophagus | ESCC | 2.00e-35 | 8.51e-01 | 0.1327 |
64776 | C11orf1 | P8T-E | Human | Esophagus | ESCC | 8.01e-08 | -9.09e-03 | 0.0889 |
64776 | C11orf1 | P9T-E | Human | Esophagus | ESCC | 1.74e-13 | 3.53e-01 | 0.1131 |
64776 | C11orf1 | P10T-E | Human | Esophagus | ESCC | 1.18e-19 | 1.62e-01 | 0.116 |
64776 | C11orf1 | P12T-E | Human | Esophagus | ESCC | 9.01e-32 | 7.96e-01 | 0.1122 |
64776 | C11orf1 | P15T-E | Human | Esophagus | ESCC | 5.01e-18 | 1.61e-01 | 0.1149 |
64776 | C11orf1 | P16T-E | Human | Esophagus | ESCC | 9.92e-34 | 8.48e-01 | 0.1153 |
64776 | C11orf1 | P20T-E | Human | Esophagus | ESCC | 2.58e-24 | 2.54e-01 | 0.1124 |
64776 | C11orf1 | P21T-E | Human | Esophagus | ESCC | 6.00e-21 | 5.28e-01 | 0.1617 |
64776 | C11orf1 | P22T-E | Human | Esophagus | ESCC | 5.87e-22 | 2.76e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C11orf1 | SNV | Missense_Mutation | novel | c.135N>G | p.Asn45Lys | p.N45K | Q9H5F2 | protein_coding | deleterious(0.02) | benign(0.357) | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
C11orf1 | SNV | Missense_Mutation | c.10T>G | p.Ser4Ala | p.S4A | Q9H5F2 | protein_coding | tolerated_low_confidence(0.17) | benign(0.003) | TCGA-A6-5657-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
C11orf1 | SNV | Missense_Mutation | rs782291488 | c.167N>A | p.Arg56Gln | p.R56Q | Q9H5F2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
C11orf1 | SNV | Missense_Mutation | novel | c.184A>C | p.Asn62His | p.N62H | Q9H5F2 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C11orf1 | SNV | Missense_Mutation | c.146A>C | p.Lys49Thr | p.K49T | Q9H5F2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C11orf1 | SNV | Missense_Mutation | rs151235350 | c.272N>T | p.Ser91Phe | p.S91F | Q9H5F2 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
C11orf1 | SNV | Missense_Mutation | novel | c.307A>G | p.Thr103Ala | p.T103A | Q9H5F2 | protein_coding | tolerated(0.35) | benign(0.001) | TCGA-BG-A3EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C11orf1 | SNV | Missense_Mutation | c.150N>G | p.Phe50Leu | p.F50L | Q9H5F2 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C11orf1 | SNV | Missense_Mutation | rs782079457 | c.37N>A | p.Leu13Ile | p.L13I | Q9H5F2 | protein_coding | tolerated_low_confidence(0.3) | benign(0) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
C11orf1 | SNV | Missense_Mutation | c.53N>T | p.Asn18Ile | p.N18I | Q9H5F2 | protein_coding | tolerated(0.34) | benign(0.015) | TCGA-DD-A4NF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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