![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C10orf35 |
Gene summary for C10ORF35 |
![]() |
Gene information | Species | Human | Gene symbol | C10orf35 | Gene ID | 219738 |
Gene name | family with sequence similarity 241 member B | |
Gene Alias | C10orf35 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024QZL0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219738 | C10orf35 | P1T-E | Human | Esophagus | ESCC | 3.16e-02 | 1.75e-01 | 0.0875 |
219738 | C10orf35 | P2T-E | Human | Esophagus | ESCC | 3.95e-30 | 5.03e-01 | 0.1177 |
219738 | C10orf35 | P4T-E | Human | Esophagus | ESCC | 1.38e-31 | 6.81e-01 | 0.1323 |
219738 | C10orf35 | P5T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.87e-01 | 0.1327 |
219738 | C10orf35 | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.29e-01 | 0.0889 |
219738 | C10orf35 | P9T-E | Human | Esophagus | ESCC | 4.46e-02 | 6.31e-02 | 0.1131 |
219738 | C10orf35 | P10T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.74e-01 | 0.116 |
219738 | C10orf35 | P11T-E | Human | Esophagus | ESCC | 3.07e-13 | 4.56e-01 | 0.1426 |
219738 | C10orf35 | P12T-E | Human | Esophagus | ESCC | 5.68e-24 | 4.17e-01 | 0.1122 |
219738 | C10orf35 | P15T-E | Human | Esophagus | ESCC | 4.06e-10 | 1.99e-01 | 0.1149 |
219738 | C10orf35 | P16T-E | Human | Esophagus | ESCC | 2.94e-28 | 4.55e-01 | 0.1153 |
219738 | C10orf35 | P17T-E | Human | Esophagus | ESCC | 5.52e-05 | 1.81e-01 | 0.1278 |
219738 | C10orf35 | P19T-E | Human | Esophagus | ESCC | 1.83e-02 | 3.04e-01 | 0.1662 |
219738 | C10orf35 | P20T-E | Human | Esophagus | ESCC | 6.65e-14 | 2.34e-01 | 0.1124 |
219738 | C10orf35 | P21T-E | Human | Esophagus | ESCC | 1.02e-31 | 5.85e-01 | 0.1617 |
219738 | C10orf35 | P22T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.59e-01 | 0.1236 |
219738 | C10orf35 | P23T-E | Human | Esophagus | ESCC | 8.21e-09 | 2.39e-01 | 0.108 |
219738 | C10orf35 | P24T-E | Human | Esophagus | ESCC | 1.00e-24 | 4.66e-01 | 0.1287 |
219738 | C10orf35 | P26T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.36e-01 | 0.1276 |
219738 | C10orf35 | P27T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.42e-01 | 0.1055 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C10orf35 | insertion | Frame_Shift_Ins | novel | c.289_290insGACCACACAA | p.Leu97ArgfsTer34 | p.L97Rfs*34 | Q96D05 | protein_coding | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C10orf35 | SNV | Missense_Mutation | c.316N>A | p.Leu106Ile | p.L106I | Q96D05 | protein_coding | tolerated(0.18) | probably_damaging(0.986) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
C10orf35 | SNV | Missense_Mutation | novel | c.77N>A | p.Arg26Lys | p.R26K | Q96D05 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C10orf35 | SNV | Missense_Mutation | novel | c.241N>A | p.Leu81Ile | p.L81I | Q96D05 | protein_coding | tolerated(0.21) | benign(0.276) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C10orf35 | SNV | Missense_Mutation | c.310C>T | p.Arg104Cys | p.R104C | Q96D05 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
C10orf35 | SNV | Missense_Mutation | rs758997308 | c.31N>A | p.Val11Met | p.V11M | Q96D05 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C10orf35 | SNV | Missense_Mutation | c.310C>T | p.Arg104Cys | p.R104C | Q96D05 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C10orf35 | SNV | Missense_Mutation | novel | c.164N>T | p.Ala55Val | p.A55V | Q96D05 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
C10orf35 | SNV | Missense_Mutation | c.362N>A | p.Arg121Gln | p.R121Q | Q96D05 | protein_coding | tolerated(0.11) | probably_damaging(0.986) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C10orf35 | SNV | Missense_Mutation | c.362G>A | p.Arg121Gln | p.R121Q | Q96D05 | protein_coding | tolerated(0.11) | probably_damaging(0.986) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |