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Gene: C10orf32 |
Gene summary for C10ORF32 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C10orf32 | Gene ID | 119032 |
Gene name | BLOC-1 related complex subunit 7 | |
Gene Alias | C10orf32 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0000323 | UniProtAcc | A0A0B4J1R7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
119032 | C10orf32 | P1_S1_AK | Human | Skin | AK | 3.76e-02 | -1.11e-01 | -0.3399 |
119032 | C10orf32 | P2_S3_AK | Human | Skin | AK | 1.79e-02 | -1.11e-01 | -0.3287 |
119032 | C10orf32 | P2_S4_SCCIS | Human | Skin | SCCIS | 3.76e-02 | -1.11e-01 | -0.3043 |
119032 | C10orf32 | P3_S6_AK | Human | Skin | AK | 1.79e-02 | -1.11e-01 | -0.3256 |
119032 | C10orf32 | P5_S10_cSCC | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.299 |
119032 | C10orf32 | P1_cSCC | Human | Skin | cSCC | 8.73e-23 | 8.20e-01 | 0.0292 |
119032 | C10orf32 | P2_cSCC | Human | Skin | cSCC | 2.93e-16 | 5.13e-01 | -0.024 |
119032 | C10orf32 | P4_cSCC | Human | Skin | cSCC | 2.50e-15 | 4.09e-01 | -0.00290000000000005 |
119032 | C10orf32 | P10_cSCC | Human | Skin | cSCC | 4.65e-15 | 5.45e-01 | 0.1017 |
119032 | C10orf32 | cSCC_p1 | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.1916 |
119032 | C10orf32 | cSCC_p10 | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.2095 |
119032 | C10orf32 | cSCC_p11 | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.2102 |
119032 | C10orf32 | cSCC_p3 | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.2085 |
119032 | C10orf32 | cSCC_p6 | Human | Skin | cSCC | 3.76e-02 | -1.11e-01 | -0.1989 |
119032 | C10orf32 | cSCC_p8 | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.1971 |
119032 | C10orf32 | cSCC_p9 | Human | Skin | cSCC | 1.79e-02 | -1.11e-01 | -0.1991 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Skin | AK: Actinic keratosis | |
cSCC: Cutaneous squamous cell carcinoma | ||
SCCIS:squamous cell carcinoma in situ |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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