|
Gene: C10orf118 |
Gene summary for C10ORF118 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C10orf118 | Gene ID | 55088 |
Gene name | coiled-coil domain containing 186 | |
Gene Alias | C10orf118 | |
Cytomap | 10q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | Q496Y1 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55088 | C10orf118 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 7.14e-06 | 6.52e-01 | 0.159 |
55088 | C10orf118 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 3.83e-03 | 5.71e-01 | 0.156 |
55088 | C10orf118 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 3.54e-05 | 5.59e-01 | 0.1479 |
55088 | C10orf118 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 2.22e-03 | 5.48e-01 | 0.1531 |
55088 | C10orf118 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 2.58e-19 | 6.46e-01 | 0.1633 |
55088 | C10orf118 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.22e-24 | 7.48e-01 | 0.1608 |
55088 | C10orf118 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 3.75e-15 | 5.89e-01 | 0.1604 |
55088 | C10orf118 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 8.78e-19 | 6.00e-01 | 0.1621 |
55088 | C10orf118 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 1.50e-10 | 7.10e-01 | 0.1619 |
55088 | C10orf118 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 4.40e-03 | 4.07e-01 | 0.159 |
55088 | C10orf118 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 1.73e-08 | 4.94e-01 | 0.1602 |
55088 | C10orf118 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.29e-08 | 5.97e-01 | 0.1608 |
55088 | C10orf118 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 6.72e-08 | 6.01e-01 | 0.1622 |
55088 | C10orf118 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 2.06e-14 | 5.05e-01 | 0.1575 |
55088 | C10orf118 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 5.42e-11 | 4.88e-01 | 0.1545 |
55088 | C10orf118 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.43e-10 | 5.64e-01 | 0.1569 |
55088 | C10orf118 | GSM5353248_PA_PR5269_4_S28_L002 | Human | Prostate | Tumor | 3.48e-06 | 8.27e-01 | 0.1541 |
55088 | C10orf118 | P1_S1_AK | Human | Skin | AK | 8.97e-04 | -1.34e-01 | -0.3399 |
55088 | C10orf118 | P2_S3_AK | Human | Skin | AK | 4.24e-04 | -1.34e-01 | -0.3287 |
55088 | C10orf118 | P2_S4_SCCIS | Human | Skin | SCCIS | 1.90e-03 | -1.34e-01 | -0.3043 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Prostate | BPH: Benign Prostatic Hyperplasia | |
Skin | AK: Actinic keratosis | |
cSCC: Cutaneous squamous cell carcinoma | ||
SCCIS:squamous cell carcinoma in situ |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |