Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: BUD23

Gene summary for BUD23

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

BUD23

Gene ID

114049

Gene nameBUD23 rRNA methyltransferase and ribosome maturation factor
Gene AliasHASJ4442
Cytomap7q11.23
Gene Typeprotein-coding
GO ID

GO:0000154

UniProtAcc

O43709


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
114049BUD23AEH-subject1HumanEndometriumAEH2.01e-315.82e-01-0.3059
114049BUD23AEH-subject2HumanEndometriumAEH6.52e-245.32e-01-0.2525
114049BUD23AEH-subject3HumanEndometriumAEH6.74e-366.22e-01-0.2576
114049BUD23AEH-subject4HumanEndometriumAEH3.26e-194.54e-01-0.2657
114049BUD23AEH-subject5HumanEndometriumAEH2.58e-152.93e-01-0.2953
114049BUD23EEC-subject1HumanEndometriumEEC9.89e-173.92e-01-0.2682
114049BUD23EEC-subject2HumanEndometriumEEC5.65e-204.18e-01-0.2607
114049BUD23EEC-subject3HumanEndometriumEEC1.85e-092.47e-01-0.2525
114049BUD23EEC-subject4HumanEndometriumEEC1.60e-183.67e-01-0.2571
114049BUD23EEC-subject5HumanEndometriumEEC1.73e-274.83e-01-0.249
114049BUD23GSM5276934HumanEndometriumEEC1.93e-294.87e-01-0.0913
114049BUD23GSM5276935HumanEndometriumEEC4.35e-485.54e-01-0.123
114049BUD23GSM5276937HumanEndometriumEEC2.24e-406.32e-01-0.0897
114049BUD23GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC3.94e-103.86e-01-0.1869
114049BUD23GSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC6.74e-094.13e-01-0.1875
114049BUD23GSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC8.61e-063.05e-01-0.1883
114049BUD23GSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC3.21e-134.43e-01-0.1934
114049BUD23GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC8.77e-083.37e-01-0.1917
114049BUD23GSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC5.51e-052.55e-01-0.1916
114049BUD23GSM6177623_NYU_UCEC3_VisHumanEndometriumEEC2.01e-315.09e-01-0.1269
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:002261316EndometriumAEHribonucleoprotein complex biogenesis107/2100463/187231.43e-134.08e-11107
GO:004225416EndometriumAEHribosome biogenesis67/2100299/187231.95e-081.18e-0667
GO:00063648EndometriumAEHrRNA processing47/2100225/187231.78e-053.65e-0447
GO:00160728EndometriumAEHrRNA metabolic process48/2100236/187233.01e-055.54e-0448
GO:00063258EndometriumAEHchromatin organization64/2100409/187233.69e-032.52e-0264
GO:00344707EndometriumAEHncRNA processing62/2100395/187233.93e-032.65e-0262
GO:002261317EndometriumEECribonucleoprotein complex biogenesis108/2168463/187234.60e-139.86e-11108
GO:004225417EndometriumEECribosome biogenesis68/2168299/187232.90e-081.68e-0668
GO:000636416EndometriumEECrRNA processing48/2168225/187231.88e-053.50e-0448
GO:001607216EndometriumEECrRNA metabolic process49/2168236/187233.27e-055.62e-0449
GO:000632513EndometriumEECchromatin organization65/2168409/187234.98e-033.14e-0265
GO:003447012EndometriumEECncRNA processing63/2168395/187235.20e-033.26e-0263
GO:002261327EsophagusHGINribonucleoprotein complex biogenesis158/2587463/187232.61e-295.23e-26158
GO:004225426EsophagusHGINribosome biogenesis101/2587299/187238.74e-194.03e-16101
GO:001607219EsophagusHGINrRNA metabolic process72/2587236/187232.26e-112.56e-0972
GO:000636419EsophagusHGINrRNA processing69/2587225/187234.53e-115.04e-0969
GO:003447010EsophagusHGINncRNA processing97/2587395/187235.92e-093.90e-0797
GO:000632516EsophagusHGINchromatin organization92/2587409/187231.05e-064.16e-0592
GO:00346606EsophagusHGINncRNA metabolic process104/2587485/187232.26e-068.23e-05104
GO:0022613111EsophagusESCCribonucleoprotein complex biogenesis365/8552463/187231.74e-491.11e-45365
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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