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Gene: BTNL8 |
Gene summary for BTNL8 |
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Gene information | Species | Human | Gene symbol | BTNL8 | Gene ID | 79908 |
Gene name | butyrophilin like 8 | |
Gene Alias | BTN9.2 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q6UX41 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79908 | BTNL8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.54e-09 | 6.08e-01 | -0.1808 |
79908 | BTNL8 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.79e-14 | 7.40e-01 | -0.1954 |
79908 | BTNL8 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.67e-04 | 1.14e+00 | -0.2602 |
79908 | BTNL8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.70e-04 | 8.07e-01 | -0.2196 |
79908 | BTNL8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-02 | 3.73e-01 | -0.1207 |
79908 | BTNL8 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.35e-04 | 5.13e-01 | -0.1526 |
79908 | BTNL8 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.13e-03 | 3.89e-01 | -0.1464 |
79908 | BTNL8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.55e-08 | 9.09e-01 | -0.2061 |
79908 | BTNL8 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.73e-02 | -2.45e-01 | 0.3005 |
79908 | BTNL8 | A002-C-205 | Human | Colorectum | FAP | 2.20e-02 | -2.09e-01 | -0.1236 |
79908 | BTNL8 | A002-C-114 | Human | Colorectum | FAP | 4.93e-02 | -2.11e-01 | -0.1561 |
79908 | BTNL8 | A002-C-116 | Human | Colorectum | FAP | 1.88e-02 | -1.59e-01 | -0.0452 |
79908 | BTNL8 | F072B | Human | Colorectum | FAP | 1.05e-08 | 5.28e-01 | 0.257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTNL8 | SNV | Missense_Mutation | novel | c.998N>A | p.Ser333Tyr | p.S333Y | Q6UX41 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | novel | c.786G>T | p.Gln262His | p.Q262H | Q6UX41 | protein_coding | tolerated(0.07) | benign(0.133) | TCGA-B6-A40C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | cyclophosphamide | SD |
BTNL8 | SNV | Missense_Mutation | c.1453G>A | p.Glu485Lys | p.E485K | Q6UX41 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-BH-A1F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTNL8 | SNV | Missense_Mutation | c.1192N>A | p.Val398Ile | p.V398I | Q6UX41 | protein_coding | tolerated(0.09) | benign(0) | TCGA-E2-A15O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | PD | |
BTNL8 | deletion | Frame_Shift_Del | novel | c.628delN | p.His210MetfsTer4 | p.H210Mfs*4 | Q6UX41 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
BTNL8 | SNV | Missense_Mutation | c.1180N>T | p.Arg394Cys | p.R394C | Q6UX41 | protein_coding | deleterious(0.01) | possibly_damaging(0.571) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
BTNL8 | SNV | Missense_Mutation | c.242N>G | p.Tyr81Cys | p.Y81C | Q6UX41 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BTNL8 | SNV | Missense_Mutation | rs751803412 | c.601G>A | p.Ala201Thr | p.A201T | Q6UX41 | protein_coding | tolerated(0.47) | benign(0.009) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | rs769402531 | c.106G>A | p.Ala36Thr | p.A36T | Q6UX41 | protein_coding | tolerated(0.14) | probably_damaging(0.956) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BTNL8 | SNV | Missense_Mutation | rs776813203 | c.160C>T | p.Arg54Trp | p.R54W | Q6UX41 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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