Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: BTF3

Gene summary for BTF3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

BTF3

Gene ID

689

Gene namebasic transcription factor 3
Gene AliasBETA-NAC
Cytomap5q13.2
Gene Typeprotein-coding
GO ID

GO:0001701

UniProtAcc

P20290


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
689BTF3GSM4909281HumanBreastIDC3.10e-38-3.78e-010.21
689BTF3GSM4909282HumanBreastIDC1.19e-25-2.98e-01-0.0288
689BTF3GSM4909286HumanBreastIDC1.16e-46-3.33e-010.1081
689BTF3GSM4909287HumanBreastIDC3.41e-35-6.35e-010.2057
689BTF3GSM4909288HumanBreastIDC2.91e-06-3.06e-010.0988
689BTF3GSM4909290HumanBreastIDC3.29e-16-4.23e-010.2096
689BTF3GSM4909291HumanBreastIDC4.13e-18-4.60e-010.1753
689BTF3GSM4909292HumanBreastIDC3.50e-12-9.58e-010.1236
689BTF3GSM4909293HumanBreastIDC1.09e-15-1.35e-010.1581
689BTF3GSM4909294HumanBreastIDC2.05e-08-2.67e-010.2022
689BTF3GSM4909295HumanBreastIDC4.92e-04-3.44e-010.0898
689BTF3GSM4909297HumanBreastIDC7.33e-17-2.05e-010.1517
689BTF3GSM4909298HumanBreastIDC8.98e-031.63e-010.1551
689BTF3GSM4909301HumanBreastIDC5.12e-23-3.27e-010.1577
689BTF3GSM4909302HumanBreastIDC1.09e-09-3.75e-010.1545
689BTF3GSM4909304HumanBreastIDC3.97e-22-2.24e-010.1636
689BTF3GSM4909305HumanBreastIDC1.42e-021.31e-010.0436
689BTF3GSM4909306HumanBreastIDC2.30e-03-1.20e-010.1564
689BTF3GSM4909307HumanBreastIDC2.35e-081.18e-010.1569
689BTF3GSM4909308HumanBreastIDC3.16e-272.56e-010.158
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000170113BreastIDCin utero embryonic development42/1434367/187235.85e-034.24e-0242
GO:000170122BreastDCISin utero embryonic development41/1390367/187235.74e-034.13e-0241
GO:00017018CervixCCin utero embryonic development71/2311367/187237.21e-051.00e-0371
GO:0001701ColorectumADin utero embryonic development110/3918367/187232.36e-054.62e-04110
GO:00017011ColorectumSERin utero embryonic development77/2897367/187232.77e-032.48e-0277
GO:00017012ColorectumMSSin utero embryonic development99/3467367/187233.71e-057.10e-0499
GO:00017013ColorectumFAPin utero embryonic development81/2622367/187231.58e-054.10e-0481
GO:00017019EndometriumAEHin utero embryonic development73/2100367/187237.18e-072.63e-0573
GO:000170114EndometriumEECin utero embryonic development75/2168367/187235.86e-072.16e-0575
GO:000170118EsophagusHGINin utero embryonic development77/2587367/187239.56e-052.05e-0377
GO:000170119EsophagusESCCin utero embryonic development243/8552367/187231.00e-156.86e-14243
GO:00017015LiverCirrhoticin utero embryonic development134/4634367/187232.78e-076.86e-06134
GO:000170111LiverHCCin utero embryonic development204/7958367/187232.44e-074.30e-06204
GO:00017016LungIACin utero embryonic development68/2061367/187231.12e-053.45e-0468
GO:000170112LungAISin utero embryonic development59/1849367/187231.20e-042.75e-0359
GO:000170131LungMIACin utero embryonic development33/967367/187231.44e-032.54e-0233
GO:000170116Oral cavityOSCCin utero embryonic development207/7305367/187237.92e-122.95e-10207
GO:000170117Oral cavityLPin utero embryonic development142/4623367/187231.48e-096.75e-08142
GO:000170123Oral cavityEOLPin utero embryonic development72/2218367/187231.02e-051.83e-0472
GO:000170132Oral cavityNEOLPin utero embryonic development76/2005367/187231.11e-085.44e-0776
Page: 1 2 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
BTF3SNVMissense_Mutationnovelc.215N>Cp.Arg72Thrp.R72TP20290protein_codingdeleterious(0)possibly_damaging(0.642)TCGA-3C-AALI-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPoly EComplete Response
BTF3SNVMissense_Mutationrs750408507c.179N>Ap.Ala60Glup.A60EP20290protein_codingtolerated(0.05)benign(0.015)TCGA-E9-A295-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
BTF3SNVMissense_Mutationnovelc.473N>Cp.Ser158Thrp.S158TP20290protein_codingtolerated(0.1)possibly_damaging(0.448)TCGA-EW-A3U0-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycisplatinCR
BTF3SNVMissense_Mutationc.415N>Cp.Glu139Glnp.E139QP20290protein_codingtolerated(0.2)possibly_damaging(0.669)TCGA-GM-A2DO-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenCR
BTF3deletionFrame_Shift_Delnovelc.355delNp.Asn119ThrfsTer25p.N119Tfs*25P20290protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
BTF3SNVMissense_Mutationnovelc.41G>Ap.Gly14Glup.G14EP20290protein_codingdeleterious_low_confidence(0.02)benign(0.022)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
BTF3SNVMissense_Mutationc.286G>Cp.Gly96Argp.G96RP20290protein_codingdeleterious(0.04)benign(0.125)TCGA-A6-2681-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
BTF3SNVMissense_Mutationc.597N>Cp.Glu199Aspp.E199DP20290protein_codingtolerated(0.06)benign(0.059)TCGA-AA-3979-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
BTF3SNVMissense_Mutationnovelc.614N>Gp.Ala205Glyp.A205GP20290protein_codingdeleterious(0.04)benign(0.037)TCGA-AJ-A3EL-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
BTF3SNVMissense_Mutationc.343N>Tp.Val115Leup.V115LP20290protein_codingdeleterious(0)possibly_damaging(0.553)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 2 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1