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Gene: BTBD11 |
Gene summary for BTBD11 |
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Gene information | Species | Human | Gene symbol | BTBD11 | Gene ID | 121551 |
Gene name | BTB domain containing 11 | |
Gene Alias | ABTB2B | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A6QL63 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121551 | BTBD11 | CCI_1 | Human | Cervix | CC | 1.82e-12 | 1.32e+00 | 0.528 |
121551 | BTBD11 | CCI_3 | Human | Cervix | CC | 4.87e-11 | 1.09e+00 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071786 | Cervix | CC | transmembrane receptor protein serine/threonine kinase signaling pathway | 67/2311 | 355/18723 | 2.39e-04 | 2.67e-03 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTBD11 | SNV | Missense_Mutation | rs776541174 | c.2128C>T | p.Arg710Cys | p.R710C | A6QL63 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A7-A4SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
BTBD11 | SNV | Missense_Mutation | c.1871T>G | p.Leu624Arg | p.L624R | A6QL63 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
BTBD11 | SNV | Missense_Mutation | c.1915N>T | p.His639Tyr | p.H639Y | A6QL63 | protein_coding | tolerated(0.72) | possibly_damaging(0.908) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTBD11 | SNV | Missense_Mutation | rs778909631 | c.2442N>G | p.Ile814Met | p.I814M | A6QL63 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BTBD11 | SNV | Missense_Mutation | novel | c.247N>C | p.Ala83Pro | p.A83P | A6QL63 | protein_coding | tolerated(0.35) | benign(0.176) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BTBD11 | SNV | Missense_Mutation | novel | c.3181G>A | p.Glu1061Lys | p.E1061K | A6QL63 | protein_coding | tolerated(0.06) | benign(0.353) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
BTBD11 | SNV | Missense_Mutation | novel | c.1300N>T | p.Arg434Cys | p.R434C | A6QL63 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
BTBD11 | SNV | Missense_Mutation | c.2696N>A | p.Pro899His | p.P899H | A6QL63 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BTBD11 | SNV | Missense_Mutation | c.1419N>A | p.Phe473Leu | p.F473L | A6QL63 | protein_coding | deleterious(0.02) | probably_damaging(0.952) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BTBD11 | SNV | Missense_Mutation | c.3238N>A | p.Leu1080Ile | p.L1080I | A6QL63 | protein_coding | deleterious(0.02) | possibly_damaging(0.782) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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