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Gene: BROX |
Gene summary for BROX |
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Gene information | Species | Human | Gene symbol | BROX | Gene ID | 148362 |
Gene name | BRO1 domain and CAAX motif containing | |
Gene Alias | C1orf58 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5VW32 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148362 | BROX | LZE2T | Human | Esophagus | ESCC | 7.56e-07 | 8.25e-01 | 0.082 |
148362 | BROX | LZE4T | Human | Esophagus | ESCC | 2.03e-13 | 3.61e-01 | 0.0811 |
148362 | BROX | LZE5T | Human | Esophagus | ESCC | 3.96e-04 | 4.34e-01 | 0.0514 |
148362 | BROX | LZE7T | Human | Esophagus | ESCC | 2.12e-07 | 4.16e-01 | 0.0667 |
148362 | BROX | LZE20T | Human | Esophagus | ESCC | 5.76e-12 | 1.87e-01 | 0.0662 |
148362 | BROX | LZE22T | Human | Esophagus | ESCC | 8.39e-03 | 2.58e-01 | 0.068 |
148362 | BROX | LZE24T | Human | Esophagus | ESCC | 4.20e-15 | 3.91e-01 | 0.0596 |
148362 | BROX | LZE21T | Human | Esophagus | ESCC | 4.93e-02 | 2.61e-01 | 0.0655 |
148362 | BROX | LZE6T | Human | Esophagus | ESCC | 8.45e-03 | 9.95e-02 | 0.0845 |
148362 | BROX | P1T-E | Human | Esophagus | ESCC | 8.45e-12 | 5.93e-01 | 0.0875 |
148362 | BROX | P2T-E | Human | Esophagus | ESCC | 8.71e-23 | 3.36e-01 | 0.1177 |
148362 | BROX | P4T-E | Human | Esophagus | ESCC | 4.28e-16 | 3.10e-01 | 0.1323 |
148362 | BROX | P5T-E | Human | Esophagus | ESCC | 3.12e-20 | 4.16e-01 | 0.1327 |
148362 | BROX | P8T-E | Human | Esophagus | ESCC | 1.85e-20 | 3.72e-01 | 0.0889 |
148362 | BROX | P9T-E | Human | Esophagus | ESCC | 1.24e-19 | 2.86e-01 | 0.1131 |
148362 | BROX | P10T-E | Human | Esophagus | ESCC | 5.58e-16 | 2.18e-01 | 0.116 |
148362 | BROX | P11T-E | Human | Esophagus | ESCC | 8.84e-09 | 2.71e-01 | 0.1426 |
148362 | BROX | P12T-E | Human | Esophagus | ESCC | 1.51e-08 | 2.08e-01 | 0.1122 |
148362 | BROX | P15T-E | Human | Esophagus | ESCC | 3.33e-21 | 3.20e-01 | 0.1149 |
148362 | BROX | P16T-E | Human | Esophagus | ESCC | 8.04e-15 | 2.45e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BROX | SNV | Missense_Mutation | novel | c.108N>C | p.Leu36Phe | p.L36F | Q5VW32 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
BROX | SNV | Missense_Mutation | c.798N>T | p.Lys266Asn | p.K266N | Q5VW32 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD | |
BROX | SNV | Missense_Mutation | c.1181N>A | p.Pro394His | p.P394H | Q5VW32 | protein_coding | deleterious(0) | benign(0.205) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
BROX | SNV | Missense_Mutation | novel | c.691N>C | p.Glu231Gln | p.E231Q | Q5VW32 | protein_coding | deleterious(0.03) | benign(0.188) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
BROX | SNV | Missense_Mutation | c.556N>G | p.Gln186Glu | p.Q186E | Q5VW32 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
BROX | SNV | Missense_Mutation | novel | c.961G>C | p.Glu321Gln | p.E321Q | Q5VW32 | protein_coding | tolerated(0.05) | benign(0.015) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BROX | SNV | Missense_Mutation | c.221C>A | p.Ser74Tyr | p.S74Y | Q5VW32 | protein_coding | deleterious(0.03) | possibly_damaging(0.866) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BROX | SNV | Missense_Mutation | c.881N>T | p.Thr294Ile | p.T294I | Q5VW32 | protein_coding | tolerated(0.07) | benign(0.145) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
BROX | SNV | Missense_Mutation | novel | c.185N>C | p.Asp62Ala | p.D62A | Q5VW32 | protein_coding | tolerated(0.32) | benign(0.144) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
BROX | SNV | Missense_Mutation | c.221N>A | p.Ser74Tyr | p.S74Y | Q5VW32 | protein_coding | deleterious(0.03) | possibly_damaging(0.866) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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