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Gene: BRI3 |
Gene summary for BRI3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BRI3 | Gene ID | 25798 |
| Gene name | brain protein I3 | |
| Gene Alias | I3 | |
| Cytomap | 7q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0000323 | UniProtAcc | F5GXW6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 25798 | BRI3 | GSM4909282 | Human | Breast | IDC | 3.60e-39 | 7.27e-01 | -0.0288 |
| 25798 | BRI3 | GSM4909285 | Human | Breast | IDC | 1.84e-04 | -3.16e-01 | 0.21 |
| 25798 | BRI3 | GSM4909286 | Human | Breast | IDC | 3.15e-12 | 4.06e-01 | 0.1081 |
| 25798 | BRI3 | GSM4909290 | Human | Breast | IDC | 3.97e-03 | -2.77e-01 | 0.2096 |
| 25798 | BRI3 | GSM4909291 | Human | Breast | IDC | 4.56e-08 | -3.83e-01 | 0.1753 |
| 25798 | BRI3 | GSM4909293 | Human | Breast | IDC | 7.21e-09 | 3.78e-01 | 0.1581 |
| 25798 | BRI3 | GSM4909296 | Human | Breast | IDC | 3.88e-22 | -3.50e-01 | 0.1524 |
| 25798 | BRI3 | GSM4909297 | Human | Breast | IDC | 1.82e-20 | -4.17e-01 | 0.1517 |
| 25798 | BRI3 | GSM4909298 | Human | Breast | IDC | 2.17e-11 | 3.72e-01 | 0.1551 |
| 25798 | BRI3 | GSM4909301 | Human | Breast | IDC | 7.61e-07 | -2.65e-01 | 0.1577 |
| 25798 | BRI3 | GSM4909304 | Human | Breast | IDC | 8.35e-16 | 5.16e-01 | 0.1636 |
| 25798 | BRI3 | GSM4909305 | Human | Breast | IDC | 3.61e-02 | -2.54e-01 | 0.0436 |
| 25798 | BRI3 | GSM4909306 | Human | Breast | IDC | 2.37e-05 | -3.03e-01 | 0.1564 |
| 25798 | BRI3 | GSM4909307 | Human | Breast | IDC | 2.17e-05 | -3.05e-01 | 0.1569 |
| 25798 | BRI3 | GSM4909308 | Human | Breast | IDC | 1.24e-06 | -3.16e-01 | 0.158 |
| 25798 | BRI3 | GSM4909309 | Human | Breast | IDC | 1.10e-07 | -3.21e-01 | 0.0483 |
| 25798 | BRI3 | GSM4909311 | Human | Breast | IDC | 2.07e-28 | -4.14e-01 | 0.1534 |
| 25798 | BRI3 | GSM4909312 | Human | Breast | IDC | 9.77e-22 | -4.18e-01 | 0.1552 |
| 25798 | BRI3 | GSM4909313 | Human | Breast | IDC | 7.06e-07 | -3.09e-01 | 0.0391 |
| 25798 | BRI3 | GSM4909315 | Human | Breast | IDC | 1.38e-13 | 4.78e-01 | 0.21 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| BRI3 | SNV | Missense_Mutation | rs772300526 | c.347N>A | p.Arg116Gln | p.R116Q | O95415 | protein_coding | deleterious(0.01) | possibly_damaging(0.832) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
| BRI3 | SNV | Missense_Mutation | c.236N>G | p.Pro79Arg | p.P79R | O95415 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| BRI3 | SNV | Missense_Mutation | rs766249032 | c.206N>T | p.Ala69Val | p.A69V | O95415 | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| BRI3 | SNV | Missense_Mutation | rs867982825 | c.332C>T | p.Ala111Val | p.A111V | O95415 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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