Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: BPNT2

Gene summary for BPNT2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

BPNT2

Gene ID

54928

Gene name3'(2'), 5'-bisphosphate nucleotidase 2
Gene AliasGPAPP
Cytomap8q12.1
Gene Typeprotein-coding
GO ID

GO:0001501

UniProtAcc

A0A024R7W0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54928BPNT2HTA11_1938_2000001011HumanColorectumAD1.23e-051.86e-01-0.0811
54928BPNT2HTA11_78_2000001011HumanColorectumAD8.38e-102.84e-01-0.1088
54928BPNT2HTA11_347_2000001011HumanColorectumAD3.42e-163.68e-01-0.1954
54928BPNT2HTA11_696_2000001011HumanColorectumAD1.71e-029.39e-02-0.1464
54928BPNT2HTA11_866_2000001011HumanColorectumAD1.92e-041.23e-01-0.1001
54928BPNT2HTA11_1391_2000001011HumanColorectumAD1.88e-041.43e-01-0.059
54928BPNT2HTA11_5212_2000001011HumanColorectumAD2.28e-021.93e-01-0.2061
54928BPNT2HTA11_7862_2000001011HumanColorectumAD1.12e-062.70e-01-0.0179
54928BPNT2HTA11_7663_2000001011HumanColorectumSER6.29e-032.04e-010.0131
54928BPNT2HTA11_6801_2000001011HumanColorectumSER1.41e-064.43e-010.0171
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0044282ColorectumADsmall molecule catabolic process118/3918376/187231.05e-063.55e-05118
GO:0016311ColorectumADdephosphorylation123/3918417/187231.84e-053.82e-04123
GO:0006066ColorectumADalcohol metabolic process106/3918353/187233.02e-055.57e-04106
GO:0044262ColorectumADcellular carbohydrate metabolic process87/3918283/187236.00e-051.01e-0387
GO:0006790ColorectumADsulfur compound metabolic process101/3918339/187236.46e-051.07e-03101
GO:0009791ColorectumADpost-embryonic development29/391880/187231.13e-031.03e-0229
GO:0048736ColorectumADappendage development51/3918172/187234.20e-032.89e-0251
GO:0060173ColorectumADlimb development51/3918172/187234.20e-032.89e-0251
GO:0006650ColorectumADglycerophospholipid metabolic process83/3918306/187235.40e-033.55e-0283
GO:0006644ColorectumADphospholipid metabolic process101/3918383/187235.80e-033.67e-02101
GO:0046164ColorectumADalcohol catabolic process20/391855/187236.03e-033.78e-0220
GO:0001503ColorectumADossification106/3918408/187237.68e-034.64e-02106
GO:0045017ColorectumADglycerolipid biosynthetic process69/3918252/187238.33e-034.88e-0269
GO:00442821ColorectumSERsmall molecule catabolic process87/2897376/187235.31e-051.27e-0387
GO:00060661ColorectumSERalcohol metabolic process79/2897353/187233.50e-045.50e-0379
GO:00487361ColorectumSERappendage development42/2897172/187231.43e-031.55e-0242
GO:00601731ColorectumSERlimb development42/2897172/187231.43e-031.55e-0242
GO:00067901ColorectumSERsulfur compound metabolic process73/2897339/187231.75e-031.81e-0273
GO:0046486ColorectumSERglycerolipid metabolic process82/2897392/187232.26e-032.17e-0282
GO:00163111ColorectumSERdephosphorylation86/2897417/187232.73e-032.46e-0286
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa00920ColorectumADSulfur metabolism8/209210/84653.78e-042.82e-031.80e-038
hsa009201ColorectumADSulfur metabolism8/209210/84653.78e-042.82e-031.80e-038
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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