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Gene: BNIP5 |
Gene summary for BNIP5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BNIP5 | Gene ID | 389384 |
| Gene name | BCL2 interacting protein 5 | |
| Gene Alias | C6orf222 | |
| Cytomap | 6p21.31 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | P0C671 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 389384 | BNIP5 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 6.61e-01 | -0.2602 |
| 389384 | BNIP5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 2.44e-01 | -0.2196 |
| 389384 | BNIP5 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.61e-02 | 8.15e-02 | -0.1464 |
| 389384 | BNIP5 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.13e-03 | 1.02e-01 | -0.1001 |
| 389384 | BNIP5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.08e-04 | 1.43e-01 | -0.059 |
| 389384 | BNIP5 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.98e-03 | 1.42e-01 | 0.096 |
| 389384 | BNIP5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.85e-03 | 9.90e-02 | 0.0674 |
| 389384 | BNIP5 | Pat01-B | Human | Stomach | GC | 3.95e-53 | 8.88e-01 | 0.5754 |
| 389384 | BNIP5 | Pat02-B | Human | Stomach | GC | 7.57e-28 | 4.71e-01 | 0.0368 |
| 389384 | BNIP5 | Pat03-B | Human | Stomach | GC | 1.13e-32 | 6.38e-01 | 0.3693 |
| 389384 | BNIP5 | Pat04-B | Human | Stomach | GC | 1.45e-22 | 6.33e-01 | -0.1483 |
| 389384 | BNIP5 | Pat05-B | Human | Stomach | GC | 3.56e-13 | 4.70e-01 | -0.0353 |
| 389384 | BNIP5 | Pat06-B | Human | Stomach | GC | 7.72e-19 | 3.72e-01 | -0.1961 |
| 389384 | BNIP5 | Pat07-B | Human | Stomach | GC | 3.71e-21 | 8.46e-01 | 0.0935 |
| 389384 | BNIP5 | Pat08-B | Human | Stomach | GC | 5.51e-06 | 3.66e-01 | 0.0182 |
| 389384 | BNIP5 | Pat10-B | Human | Stomach | GC | 1.84e-10 | 5.29e-01 | 0.084 |
| 389384 | BNIP5 | Pat11-B | Human | Stomach | GC | 2.61e-28 | 7.71e-01 | -0.182 |
| 389384 | BNIP5 | Pat12-B | Human | Stomach | GC | 2.87e-12 | 3.14e-01 | 0.0325 |
| 389384 | BNIP5 | Pat15-B | Human | Stomach | GC | 5.70e-17 | 4.54e-01 | -0.0778 |
| 389384 | BNIP5 | Pat16-B | Human | Stomach | GC | 1.40e-19 | 5.26e-01 | 0.1918 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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