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Gene: BMPER |
Gene summary for BMPER |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BMPER | Gene ID | 168667 |
| Gene name | BMP binding endothelial regulator | |
| Gene Alias | CRIM3 | |
| Cytomap | 7p14.3 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A090N7U6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 168667 | BMPER | HTA11_866_3004761011 | Human | Colorectum | AD | 1.03e-04 | 1.66e-01 | 0.096 |
| 168667 | BMPER | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.61e-27 | 5.02e-01 | 0.294 |
| 168667 | BMPER | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.81e-07 | 5.01e-01 | 0.2585 |
| 168667 | BMPER | A002-C-203 | Human | Colorectum | FAP | 4.47e-08 | 2.92e-01 | 0.2786 |
| 168667 | BMPER | A002-C-021 | Human | Colorectum | FAP | 1.20e-11 | 4.10e-01 | 0.1171 |
| 168667 | BMPER | A001-C-007 | Human | Colorectum | CRC | 4.41e-04 | 4.13e-01 | 0.1899 |
| 168667 | BMPER | F072B | Human | Colorectum | FAP | 2.20e-08 | 4.21e-01 | 0.257 |
| 168667 | BMPER | CRC-1-8810 | Human | Colorectum | CRC | 8.97e-04 | 2.15e-01 | 0.6257 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
| GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
| GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
| GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
| GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
| GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
| GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
| GO:0043542 | Colorectum | AD | endothelial cell migration | 78/3918 | 279/18723 | 2.97e-03 | 2.22e-02 | 78 |
| GO:0072073 | Colorectum | AD | kidney epithelium development | 42/3918 | 136/18723 | 4.02e-03 | 2.80e-02 | 42 |
| GO:00016672 | Colorectum | MSS | ameboidal-type cell migration | 120/3467 | 475/18723 | 1.37e-04 | 2.05e-03 | 120 |
| GO:00901322 | Colorectum | MSS | epithelium migration | 93/3467 | 360/18723 | 3.30e-04 | 4.24e-03 | 93 |
| GO:00106312 | Colorectum | MSS | epithelial cell migration | 92/3467 | 357/18723 | 3.87e-04 | 4.86e-03 | 92 |
| GO:00106322 | Colorectum | MSS | regulation of epithelial cell migration | 77/3467 | 292/18723 | 5.39e-04 | 6.04e-03 | 77 |
| GO:00901302 | Colorectum | MSS | tissue migration | 93/3467 | 365/18723 | 5.42e-04 | 6.06e-03 | 93 |
| GO:00506731 | Colorectum | MSS | epithelial cell proliferation | 108/3467 | 437/18723 | 6.76e-04 | 7.30e-03 | 108 |
| GO:00435422 | Colorectum | MSS | endothelial cell migration | 70/3467 | 279/18723 | 3.69e-03 | 2.71e-02 | 70 |
| GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
| GO:00720731 | Colorectum | MSS | kidney epithelium development | 38/3467 | 136/18723 | 4.53e-03 | 3.19e-02 | 38 |
| GO:0001655 | Colorectum | MSS | urogenital system development | 81/3467 | 338/18723 | 6.88e-03 | 4.43e-02 | 81 |
| GO:00071782 | Colorectum | FAP | transmembrane receptor protein serine/threonine kinase signaling pathway | 81/2622 | 355/18723 | 4.28e-06 | 1.46e-04 | 81 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| BMPER | SNV | Missense_Mutation | c.689N>C | p.Val230Ala | p.V230A | Q8N8U9 | protein_coding | deleterious(0.01) | possibly_damaging(0.527) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
| BMPER | SNV | Missense_Mutation | rs200453593 | c.722G>A | p.Arg241Gln | p.R241Q | Q8N8U9 | protein_coding | tolerated(0.21) | benign(0.166) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| BMPER | SNV | Missense_Mutation | c.952A>C | p.Asn318His | p.N318H | Q8N8U9 | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| BMPER | SNV | Missense_Mutation | c.1699N>A | p.Glu567Lys | p.E567K | Q8N8U9 | protein_coding | tolerated(0.33) | benign(0.053) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| BMPER | SNV | Missense_Mutation | c.1976G>T | p.Cys659Phe | p.C659F | Q8N8U9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0H0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| BMPER | SNV | Missense_Mutation | c.442N>G | p.His148Asp | p.H148D | Q8N8U9 | protein_coding | tolerated(0.11) | possibly_damaging(0.622) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| BMPER | SNV | Missense_Mutation | novel | c.151G>C | p.Glu51Gln | p.E51Q | Q8N8U9 | protein_coding | tolerated(0.12) | possibly_damaging(0.543) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| BMPER | SNV | Missense_Mutation | c.1136C>T | p.Thr379Ile | p.T379I | Q8N8U9 | protein_coding | tolerated(0.28) | benign(0.406) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| BMPER | SNV | Missense_Mutation | novel | c.544N>C | p.Glu182Gln | p.E182Q | Q8N8U9 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| BMPER | SNV | Missense_Mutation | novel | c.23N>A | p.Gly8Glu | p.G8E | Q8N8U9 | protein_coding | tolerated_low_confidence(0.42) | benign(0.015) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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