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Gene: BMP5 |
Gene summary for BMP5 |
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Gene information | Species | Human | Gene symbol | BMP5 | Gene ID | 653 |
Gene name | bone morphogenetic protein 5 | |
Gene Alias | BMP5 | |
Cytomap | 6p12.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K694 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
653 | BMP5 | HTA12-15-2 | Human | Pancreas | PDAC | 4.27e-03 | 3.69e-01 | 0.2315 |
653 | BMP5 | HTA12-23-1 | Human | Pancreas | PDAC | 2.93e-09 | 8.14e-01 | 0.3405 |
653 | BMP5 | HTA12-25-1 | Human | Pancreas | PDAC | 3.33e-07 | 5.33e-01 | 0.313 |
653 | BMP5 | HTA12-26-1 | Human | Pancreas | PDAC | 7.38e-20 | 8.36e-01 | 0.3728 |
653 | BMP5 | HTA12-29-1 | Human | Pancreas | PDAC | 8.62e-60 | 1.14e+00 | 0.3722 |
653 | BMP5 | HTA12-30-1 | Human | Pancreas | PDAC | 3.91e-06 | 1.19e+00 | 0.3671 |
653 | BMP5 | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 7.75e-01 | 0.3624 |
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Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | CRC |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | CRC | SER |
BMP5 | ACVR1_ACVR2A | BMP5_ACVR1_ACVR2A | BMP | Liver | Healthy |
BMP5 | ACVR1_ACVR2B | BMP5_ACVR1_ACVR2B | BMP | Liver | Healthy |
BMP5 | ACVR1_BMPR2 | BMP5_ACVR1_BMPR2 | BMP | Liver | Healthy |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | Liver | Healthy |
BMP5 | BMPR1A_ACVR2B | BMP5_BMPR1A_ACVR2B | BMP | Liver | Healthy |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | Liver | Healthy |
BMP5 | BMPR1B_ACVR2A | BMP5_BMPR1B_ACVR2A | BMP | Liver | Healthy |
BMP5 | BMPR1B_ACVR2B | BMP5_BMPR1B_ACVR2B | BMP | Liver | Healthy |
BMP5 | BMPR1B_BMPR2 | BMP5_BMPR1B_BMPR2 | BMP | Liver | Healthy |
BMP5 | ACVR1_ACVR2A | BMP5_ACVR1_ACVR2A | BMP | Liver | Precancer |
BMP5 | ACVR1_BMPR2 | BMP5_ACVR1_BMPR2 | BMP | Liver | Precancer |
BMP5 | BMPR1A_ACVR2A | BMP5_BMPR1A_ACVR2A | BMP | Liver | Precancer |
BMP5 | BMPR1A_BMPR2 | BMP5_BMPR1A_BMPR2 | BMP | Liver | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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