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Gene: BEND5 |
Gene summary for BEND5 |
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Gene information | Species | Human | Gene symbol | BEND5 | Gene ID | 79656 |
Gene name | BEN domain containing 5 | |
Gene Alias | C1orf165 | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7L4P6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79656 | BEND5 | P2T-E | Human | Esophagus | ESCC | 2.28e-35 | 5.63e-01 | 0.1177 |
79656 | BEND5 | P4T-E | Human | Esophagus | ESCC | 4.31e-08 | 2.05e-01 | 0.1323 |
79656 | BEND5 | P8T-E | Human | Esophagus | ESCC | 9.74e-22 | 4.01e-01 | 0.0889 |
79656 | BEND5 | P10T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.34e-01 | 0.116 |
79656 | BEND5 | P12T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.40e-01 | 0.1122 |
79656 | BEND5 | P16T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.59e-01 | 0.1153 |
79656 | BEND5 | P22T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.52e-02 | 0.1236 |
79656 | BEND5 | P23T-E | Human | Esophagus | ESCC | 3.95e-05 | 2.24e-01 | 0.108 |
79656 | BEND5 | P26T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.86e-01 | 0.1276 |
79656 | BEND5 | P27T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.07e-01 | 0.1055 |
79656 | BEND5 | P49T-E | Human | Esophagus | ESCC | 2.46e-06 | 5.34e-01 | 0.1768 |
79656 | BEND5 | P56T-E | Human | Esophagus | ESCC | 1.95e-09 | 7.57e-01 | 0.1613 |
79656 | BEND5 | P57T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.34e-01 | 0.0926 |
79656 | BEND5 | P61T-E | Human | Esophagus | ESCC | 1.39e-21 | 4.27e-01 | 0.099 |
79656 | BEND5 | P74T-E | Human | Esophagus | ESCC | 4.80e-07 | 2.37e-01 | 0.1479 |
79656 | BEND5 | P76T-E | Human | Esophagus | ESCC | 3.89e-12 | 1.91e-01 | 0.1207 |
79656 | BEND5 | P79T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.25e-01 | 0.1154 |
79656 | BEND5 | P128T-E | Human | Esophagus | ESCC | 9.28e-09 | 2.47e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BEND5 | SNV | Missense_Mutation | rs776938575 | c.1238G>A | p.Arg413Gln | p.R413Q | Q7L4P6 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.992) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BEND5 | SNV | Missense_Mutation | novel | c.1106N>C | p.Arg369Thr | p.R369T | Q7L4P6 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BEND5 | SNV | Missense_Mutation | c.1135G>C | p.Glu379Gln | p.E379Q | Q7L4P6 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
BEND5 | SNV | Missense_Mutation | novel | c.287C>T | p.Ser96Phe | p.S96F | Q7L4P6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.962) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BEND5 | SNV | Missense_Mutation | rs746087223 | c.1027N>A | p.Val343Ile | p.V343I | Q7L4P6 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BEND5 | SNV | Missense_Mutation | novel | c.832N>G | p.Thr278Ala | p.T278A | Q7L4P6 | protein_coding | deleterious(0.02) | possibly_damaging(0.899) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
BEND5 | SNV | Missense_Mutation | c.818N>A | p.Ser273Asn | p.S273N | Q7L4P6 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
BEND5 | SNV | Missense_Mutation | rs201098567 | c.592C>T | p.Arg198Cys | p.R198C | Q7L4P6 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BEND5 | SNV | Missense_Mutation | c.527N>A | p.Ala176Asp | p.A176D | Q7L4P6 | protein_coding | tolerated(0.35) | probably_damaging(0.994) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
BEND5 | SNV | Missense_Mutation | c.1151N>G | p.Thr384Ser | p.T384S | Q7L4P6 | protein_coding | tolerated(0.16) | benign(0.197) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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