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Gene: BCORL1 |
Gene summary for BCORL1 |
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Gene information | Species | Human | Gene symbol | BCORL1 | Gene ID | 63035 |
Gene name | BCL6 corepressor like 1 | |
Gene Alias | BCoR-L1 | |
Cytomap | Xq26.1 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | Q5H9F3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63035 | BCORL1 | HCC1_Meng | Human | Liver | HCC | 1.86e-13 | 3.51e-02 | 0.0246 |
63035 | BCORL1 | HCC2_Meng | Human | Liver | HCC | 3.99e-04 | 5.24e-02 | 0.0107 |
63035 | BCORL1 | HCC2 | Human | Liver | HCC | 2.63e-02 | 1.89e+00 | 0.5341 |
63035 | BCORL1 | HCC5 | Human | Liver | HCC | 2.89e-05 | 6.39e-01 | 0.4932 |
63035 | BCORL1 | S014 | Human | Liver | HCC | 1.42e-07 | 2.92e-01 | 0.2254 |
63035 | BCORL1 | S015 | Human | Liver | HCC | 1.38e-06 | 3.83e-01 | 0.2375 |
63035 | BCORL1 | S016 | Human | Liver | HCC | 1.00e-04 | 2.81e-01 | 0.2243 |
63035 | BCORL1 | S028 | Human | Liver | HCC | 1.63e-09 | 3.96e-01 | 0.2503 |
63035 | BCORL1 | S029 | Human | Liver | HCC | 1.03e-02 | 2.17e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCORL1 | SNV | Missense_Mutation | rs144041395 | c.2822G>T | p.Gly941Val | p.G941V | Q5H9F3 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-A2-A04N-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
BCORL1 | SNV | Missense_Mutation | rs144041395 | c.2822G>T | p.Gly941Val | p.G941V | Q5H9F3 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-A2-A0SV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate therapy | zometa | PD |
BCORL1 | SNV | Missense_Mutation | c.2092N>T | p.Asp698Tyr | p.D698Y | Q5H9F3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
BCORL1 | SNV | Missense_Mutation | c.1023N>A | p.Met341Ile | p.M341I | Q5H9F3 | protein_coding | tolerated_low_confidence(0.34) | benign(0) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
BCORL1 | SNV | Missense_Mutation | novel | c.2800N>T | p.Ala934Ser | p.A934S | Q5H9F3 | protein_coding | deleterious(0.05) | possibly_damaging(0.55) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
BCORL1 | SNV | Missense_Mutation | novel | c.2801N>T | p.Ala934Val | p.A934V | Q5H9F3 | protein_coding | tolerated(0.08) | probably_damaging(0.91) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
BCORL1 | SNV | Missense_Mutation | rs144041395 | c.2822N>T | p.Gly941Val | p.G941V | Q5H9F3 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-AO-A124-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
BCORL1 | SNV | Missense_Mutation | rs144041395 | c.2822G>T | p.Gly941Val | p.G941V | Q5H9F3 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-AR-A0TQ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
BCORL1 | SNV | Missense_Mutation | c.5008N>A | p.Glu1670Lys | p.E1670K | Q5H9F3 | protein_coding | tolerated(0.1) | benign(0.303) | TCGA-AR-A1AN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
BCORL1 | SNV | Missense_Mutation | rs144041395 | c.2822N>T | p.Gly941Val | p.G941V | Q5H9F3 | protein_coding | deleterious(0.02) | benign(0.205) | TCGA-B6-A0RQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
63035 | BCORL1 | CLINICALLY ACTIONABLE | N/A | 26879601 |
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