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Gene: BCL2L14 |
Gene summary for BCL2L14 |
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Gene information | Species | Human | Gene symbol | BCL2L14 | Gene ID | 79370 |
Gene name | BCL2 like 14 | |
Gene Alias | BCLG | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | A0A140VJF2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79370 | BCL2L14 | CCI_2 | Human | Cervix | CC | 1.28e-10 | 7.02e-01 | 0.5249 |
79370 | BCL2L14 | CCI_3 | Human | Cervix | CC | 4.80e-08 | 6.07e-01 | 0.516 |
79370 | BCL2L14 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.47e-08 | 6.61e-01 | -0.1088 |
79370 | BCL2L14 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.30e-25 | 8.99e-01 | -0.1954 |
79370 | BCL2L14 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.15e-03 | 4.60e-01 | -0.1464 |
79370 | BCL2L14 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.20e-06 | 4.46e-01 | -0.1001 |
79370 | BCL2L14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.82e-03 | 4.23e-01 | -0.059 |
79370 | BCL2L14 | F007 | Human | Colorectum | FAP | 6.78e-06 | -3.77e-01 | 0.1176 |
79370 | BCL2L14 | A001-C-207 | Human | Colorectum | FAP | 4.55e-02 | -2.46e-01 | 0.1278 |
79370 | BCL2L14 | A015-C-203 | Human | Colorectum | FAP | 5.81e-15 | -3.26e-01 | -0.1294 |
79370 | BCL2L14 | A015-C-204 | Human | Colorectum | FAP | 3.62e-02 | -1.90e-01 | -0.0228 |
79370 | BCL2L14 | A002-C-201 | Human | Colorectum | FAP | 7.26e-07 | -1.89e-01 | 0.0324 |
79370 | BCL2L14 | A001-C-119 | Human | Colorectum | FAP | 5.00e-04 | -3.37e-01 | -0.1557 |
79370 | BCL2L14 | A001-C-108 | Human | Colorectum | FAP | 3.81e-09 | -2.38e-01 | -0.0272 |
79370 | BCL2L14 | A002-C-205 | Human | Colorectum | FAP | 2.43e-17 | -4.38e-01 | -0.1236 |
79370 | BCL2L14 | A001-C-104 | Human | Colorectum | FAP | 1.61e-03 | -1.91e-01 | 0.0184 |
79370 | BCL2L14 | A015-C-006 | Human | Colorectum | FAP | 3.43e-07 | -2.46e-01 | -0.0994 |
79370 | BCL2L14 | A015-C-106 | Human | Colorectum | FAP | 2.60e-06 | -2.38e-01 | -0.0511 |
79370 | BCL2L14 | A002-C-114 | Human | Colorectum | FAP | 2.04e-08 | -2.08e-01 | -0.1561 |
79370 | BCL2L14 | A015-C-104 | Human | Colorectum | FAP | 9.15e-16 | -3.47e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:009719110 | Cervix | CC | extrinsic apoptotic signaling pathway | 52/2311 | 219/18723 | 2.06e-06 | 6.34e-05 | 52 |
GO:200123610 | Cervix | CC | regulation of extrinsic apoptotic signaling pathway | 37/2311 | 151/18723 | 2.80e-05 | 4.65e-04 | 37 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0097191 | Colorectum | AD | extrinsic apoptotic signaling pathway | 68/3918 | 219/18723 | 2.64e-04 | 3.27e-03 | 68 |
GO:20012334 | Colorectum | FAP | regulation of apoptotic signaling pathway | 74/2622 | 356/18723 | 2.65e-04 | 3.60e-03 | 74 |
GO:20012335 | Colorectum | CRC | regulation of apoptotic signaling pathway | 59/2078 | 356/18723 | 1.07e-03 | 1.25e-02 | 59 |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:009719122 | Liver | HCC | extrinsic apoptotic signaling pathway | 143/7958 | 219/18723 | 6.99e-12 | 2.97e-10 | 143 |
GO:200123621 | Liver | HCC | regulation of extrinsic apoptotic signaling pathway | 98/7958 | 151/18723 | 2.17e-08 | 5.08e-07 | 98 |
GO:200123332 | Liver | Cyst | regulation of apoptotic signaling pathway | 26/496 | 356/18723 | 3.37e-06 | 2.71e-04 | 26 |
GO:009719132 | Liver | Cyst | extrinsic apoptotic signaling pathway | 16/496 | 219/18723 | 2.55e-04 | 8.70e-03 | 16 |
GO:200123631 | Liver | Cyst | regulation of extrinsic apoptotic signaling pathway | 11/496 | 151/18723 | 2.32e-03 | 4.60e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCL2L14 | SNV | Missense_Mutation | novel | c.306G>T | p.Lys102Asn | p.K102N | Q9BZR8 | protein_coding | tolerated(0.08) | possibly_damaging(0.594) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
BCL2L14 | SNV | Missense_Mutation | c.316N>G | p.Gln106Glu | p.Q106E | Q9BZR8 | protein_coding | tolerated(0.54) | benign(0.006) | TCGA-BH-A28Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BCL2L14 | insertion | Nonsense_Mutation | novel | c.850_851insATGGGACAGAATGAGAAACAGCGAGAAAA | p.Ala284AspfsTer5 | p.A284Dfs*5 | Q9BZR8 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
BCL2L14 | SNV | Missense_Mutation | c.119N>A | p.Pro40His | p.P40H | Q9BZR8 | protein_coding | deleterious(0.03) | probably_damaging(0.939) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BCL2L14 | SNV | Missense_Mutation | c.314N>T | p.Ser105Leu | p.S105L | Q9BZR8 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
BCL2L14 | SNV | Missense_Mutation | novel | c.689N>C | p.Asp230Ala | p.D230A | Q9BZR8 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
BCL2L14 | SNV | Missense_Mutation | c.765N>A | p.Met255Ile | p.M255I | Q9BZR8 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-G4-6293-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
BCL2L14 | SNV | Missense_Mutation | c.13N>G | p.Ser5Gly | p.S5G | Q9BZR8 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BCL2L14 | SNV | Missense_Mutation | novel | c.368N>G | p.Gln123Arg | p.Q123R | Q9BZR8 | protein_coding | tolerated(0.23) | benign(0.385) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BCL2L14 | SNV | Missense_Mutation | novel | c.218N>A | p.Pro73His | p.P73H | Q9BZR8 | protein_coding | deleterious(0.03) | probably_damaging(0.939) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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