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Gene: BATF3 |
Gene summary for BATF3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BATF3 | Gene ID | 55509 |
| Gene name | basic leucine zipper ATF-like transcription factor 3 | |
| Gene Alias | JDP1 | |
| Cytomap | 1q32.3 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NR55 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55509 | BATF3 | PTC04 | Human | Thyroid | PTC | 2.29e-02 | 1.68e-01 | 0.1927 |
| 55509 | BATF3 | ATC13 | Human | Thyroid | ATC | 8.48e-15 | 3.36e-01 | 0.34 |
| 55509 | BATF3 | ATC2 | Human | Thyroid | ATC | 1.80e-12 | 9.53e-01 | 0.34 |
| 55509 | BATF3 | ATC5 | Human | Thyroid | ATC | 1.02e-18 | 3.72e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000961520 | Thyroid | PTC | response to virus | 162/5968 | 367/18723 | 4.52e-07 | 7.41e-06 | 162 |
| GO:0030099113 | Thyroid | PTC | myeloid cell differentiation | 160/5968 | 381/18723 | 1.75e-05 | 1.82e-04 | 160 |
| GO:0009615111 | Thyroid | ATC | response to virus | 173/6293 | 367/18723 | 4.23e-08 | 7.71e-07 | 173 |
| GO:003009933 | Thyroid | ATC | myeloid cell differentiation | 170/6293 | 381/18723 | 4.26e-06 | 4.68e-05 | 170 |
| GO:0002573110 | Thyroid | ATC | myeloid leukocyte differentiation | 86/6293 | 208/18723 | 1.15e-02 | 4.11e-02 | 86 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| BATF3 | PERI | Endometrium | ADJ | COL4A1,FAM162B,ERICH1, etc. | 3.25e-01 |  |
| BATF3 | TFH | Esophagus | ADJ | ZNF350,IGLV6-57,RP11-701H24.9, etc. | 1.66e-02 |  |
| BATF3 | DC | Liver | Cirrhotic | ID1,APOBEC3A,TMSB4X, etc. | 9.31e-02 |  |
| BATF3 | AT2L | Lung | AAH | C4BPB,FGA,C1orf54, etc. | 2.17e-01 |  |
| BATF3 | AT2L | Lung | ADJ | C4BPB,FGA,C1orf54, etc. | 1.80e-01 |  |
| BATF3 | CLUB | Lung | IAC | C4BPB,FGA,C1orf54, etc. | 2.47e-01 |  |
| BATF3 | CLUB | Lung | MIAC | C4BPB,FGA,C1orf54, etc. | 8.42e-02 |  |
| BATF3 | cDC | Skin | ADJ | IRF8,C1orf54,NET1, etc. | 9.54e-02 |  |
| BATF3 | cDC | Skin | cSCC | IRF8,C1orf54,NET1, etc. | 2.15e-01 |  |
| BATF3 | cDC | Skin | Healthy | IRF8,C1orf54,NET1, etc. | 9.81e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| BATF3 | SNV | Missense_Mutation | novel | c.152G>T | p.Arg51Ile | p.R51I | Q9NR55 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| BATF3 | SNV | Missense_Mutation | rs764402872 | c.233N>A | p.Arg78Gln | p.R78Q | Q9NR55 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-BH-A1F2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| BATF3 | SNV | Missense_Mutation | c.327N>C | p.Met109Ile | p.M109I | Q9NR55 | protein_coding | tolerated(0.16) | benign(0) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| BATF3 | SNV | Missense_Mutation | c.119N>A | p.Arg40Gln | p.R40Q | Q9NR55 | protein_coding | tolerated(0.23) | probably_damaging(0.914) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| BATF3 | SNV | Missense_Mutation | c.157C>T | p.Arg53Trp | p.R53W | Q9NR55 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AA-3818-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| BATF3 | SNV | Missense_Mutation | c.119G>A | p.Arg40Gln | p.R40Q | Q9NR55 | protein_coding | tolerated(0.23) | probably_damaging(0.914) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| BATF3 | SNV | Missense_Mutation | novel | c.280N>A | p.Ala94Thr | p.A94T | Q9NR55 | protein_coding | tolerated(0.39) | benign(0.062) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| BATF3 | deletion | Frame_Shift_Del | c.134delN | p.Asn45ThrfsTer40 | p.N45Tfs*40 | Q9NR55 | protein_coding | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| BATF3 | deletion | Frame_Shift_Del | c.134delA | p.Asn45ThrfsTer40 | p.N45Tfs*40 | Q9NR55 | protein_coding | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |||
| BATF3 | SNV | Missense_Mutation | c.135N>A | p.Asn45Lys | p.N45K | Q9NR55 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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