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Gene: BAG6 |
Gene summary for BAG6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BAG6 | Gene ID | 7917 |
| Gene name | BAG cochaperone 6 | |
| Gene Alias | BAG-6 | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A1U9X7A6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7917 | BAG6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.73e-03 | 1.34e-01 | 0.0155 |
| 7917 | BAG6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.47e-05 | 3.80e-01 | -0.1808 |
| 7917 | BAG6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.64e-10 | 4.76e-01 | -0.0811 |
| 7917 | BAG6 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.22e-03 | 2.65e-01 | -0.1088 |
| 7917 | BAG6 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.83e-13 | 4.11e-01 | -0.1954 |
| 7917 | BAG6 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.22e-02 | 7.39e-01 | -0.2602 |
| 7917 | BAG6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.57e-06 | 5.79e-01 | -0.1207 |
| 7917 | BAG6 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.45e-02 | 3.14e-01 | -0.1526 |
| 7917 | BAG6 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.01e-19 | 5.15e-01 | -0.1464 |
| 7917 | BAG6 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.54e-06 | 3.06e-01 | -0.1001 |
| 7917 | BAG6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.43e-14 | 6.85e-01 | -0.059 |
| 7917 | BAG6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.86e-03 | 5.02e-01 | -0.1706 |
| 7917 | BAG6 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.75e-03 | 5.76e-01 | -0.1462 |
| 7917 | BAG6 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.81e-06 | 4.63e-01 | -0.0842 |
| 7917 | BAG6 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.16e-05 | 2.31e-01 | 0.096 |
| 7917 | BAG6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.59e-03 | 3.05e-01 | 0.0338 |
| 7917 | BAG6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.84e-08 | 3.61e-01 | 0.0674 |
| 7917 | BAG6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.75e-02 | 3.64e-01 | 0.0112 |
| 7917 | BAG6 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.95e-08 | 5.52e-01 | 0.0588 |
| 7917 | BAG6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.05e-07 | 2.54e-01 | 0.294 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
| GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
| GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
| GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
| GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
| GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
| GO:1903050 | Colorectum | AD | regulation of proteolysis involved in cellular protein catabolic process | 92/3918 | 221/18723 | 2.04e-12 | 3.19e-10 | 92 |
| GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
| GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
| GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
| GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
| GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
| GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
| GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
| GO:0042177 | Colorectum | AD | negative regulation of protein catabolic process | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
| GO:0061136 | Colorectum | AD | regulation of proteasomal protein catabolic process | 75/3918 | 187/18723 | 1.65e-09 | 1.20e-07 | 75 |
| GO:2000058 | Colorectum | AD | regulation of ubiquitin-dependent protein catabolic process | 68/3918 | 164/18723 | 1.82e-09 | 1.31e-07 | 68 |
| GO:1903363 | Colorectum | AD | negative regulation of cellular protein catabolic process | 39/3918 | 75/18723 | 2.69e-09 | 1.87e-07 | 39 |
| GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
| GO:1903364 | Colorectum | AD | positive regulation of cellular protein catabolic process | 62/3918 | 155/18723 | 4.66e-08 | 2.51e-06 | 62 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Breast | Healthy |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Cervix | ADJ |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Endometrium | AEH |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Endometrium | EEC |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Endometrium | Healthy |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | HNSCC | OSCC |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Liver | Healthy |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | Lung | AAH |
| BAG6 | NCR3 | BAG6_NCR3-PS | BAG | THCA | ADJ |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| BAG6 | SNV | Missense_Mutation | novel | c.418N>T | p.Leu140Phe | p.L140F | P46379 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| BAG6 | SNV | Missense_Mutation | novel | c.1891A>G | p.Thr631Ala | p.T631A | P46379 | protein_coding | deleterious(0.01) | benign(0.421) | TCGA-AC-A8OS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| BAG6 | SNV | Missense_Mutation | novel | c.2693G>A | p.Arg898Gln | p.R898Q | P46379 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| BAG6 | SNV | Missense_Mutation | novel | c.3131N>C | p.Ser1044Thr | p.S1044T | P46379 | protein_coding | tolerated(0.61) | probably_damaging(0.958) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
| BAG6 | SNV | Missense_Mutation | c.1472N>G | p.Gln491Arg | p.Q491R | P46379 | protein_coding | deleterious(0.01) | benign(0.363) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
| BAG6 | insertion | In_Frame_Ins | novel | c.1720_1721insAAGTGCTGGAATTACAGGCGTGGGCTACCGCGCCCAGCCTGGTGTTTGTAT | p.Ser574delinsLysValLeuGluLeuGlnAlaTrpAlaThrAlaProSerLeuValPheValCys | p.S574delinsKVLELQAWATAPSLVFVC | P46379 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| BAG6 | insertion | In_Frame_Ins | novel | c.2166_2167insCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGG | p.Ser722_Ser723insProAlaAsnPheCysIlePheSerArgAspArgValSerProTyrTrp | p.S722_S723insPANFCIFSRDRVSPYW | P46379 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
| BAG6 | insertion | Frame_Shift_Ins | novel | c.2533_2534insTTCCCCTGAGCCTCAGGTACTCTAGAGAGGGGGAGGTTGAGGG | p.Gln845LeufsTer17 | p.Q845Lfs*17 | P46379 | protein_coding | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
| BAG6 | SNV | Missense_Mutation | novel | c.95T>G | p.Ile32Ser | p.I32S | P46379 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| BAG6 | SNV | Missense_Mutation | rs745856906 | c.3307N>T | p.Arg1103Trp | p.R1103W | P46379 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7917 | BAG6 | NA | carbamazepine | CARBAMAZEPINE | 16538176 |
| Page: 1 |
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