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Gene: B3GNT7 |
Gene summary for B3GNT7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | B3GNT7 | Gene ID | 93010 |
| Gene name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 | |
| Gene Alias | beta3GnT7 | |
| Cytomap | 2q37.1 | |
| Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q8NFL0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 93010 | B3GNT7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.75e-02 | 3.60e-01 | -0.1808 |
| 93010 | B3GNT7 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.90e-69 | 1.95e+00 | -0.1954 |
| 93010 | B3GNT7 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.08e-12 | 2.84e+00 | -0.2602 |
| 93010 | B3GNT7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.93e-07 | 1.14e+00 | -0.2196 |
| 93010 | B3GNT7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.38e-28 | 1.17e+00 | -0.1464 |
| 93010 | B3GNT7 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.68e-12 | 5.32e-01 | -0.1001 |
| 93010 | B3GNT7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.74e-25 | 2.42e+00 | -0.1706 |
| 93010 | B3GNT7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.56e-37 | 2.86e+00 | -0.2061 |
| 93010 | B3GNT7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.84e-07 | 1.03e+00 | -0.1462 |
| 93010 | B3GNT7 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.00e-02 | 5.18e-01 | -0.0842 |
| 93010 | B3GNT7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.06e-37 | 2.00e+00 | -0.0179 |
| 93010 | B3GNT7 | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.82e-03 | 4.75e-01 | -0.0177 |
| 93010 | B3GNT7 | LZE24T | Human | Esophagus | ESCC | 3.66e-13 | 4.83e-01 | 0.0596 |
| 93010 | B3GNT7 | P2T-E | Human | Esophagus | ESCC | 2.29e-02 | 4.98e-02 | 0.1177 |
| 93010 | B3GNT7 | P8T-E | Human | Esophagus | ESCC | 1.39e-32 | 8.44e-01 | 0.0889 |
| 93010 | B3GNT7 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.85e-01 | 0.1149 |
| 93010 | B3GNT7 | P24T-E | Human | Esophagus | ESCC | 4.60e-02 | 4.35e-02 | 0.1287 |
| 93010 | B3GNT7 | P27T-E | Human | Esophagus | ESCC | 1.31e-07 | 8.02e-02 | 0.1055 |
| 93010 | B3GNT7 | P30T-E | Human | Esophagus | ESCC | 8.29e-05 | 3.00e-01 | 0.137 |
| 93010 | B3GNT7 | P31T-E | Human | Esophagus | ESCC | 1.28e-08 | 1.93e-01 | 0.1251 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
| GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
| GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
| GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
| GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
| GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
| GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
| GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
| GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
| GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
| GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
| GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
| GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
| GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
| GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
| GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
| GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
| GO:0006023 | Esophagus | ESCC | aminoglycan biosynthetic process | 47/8552 | 79/18723 | 9.29e-03 | 3.23e-02 | 47 |
| GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| B3GNT7 | SNV | Missense_Mutation | c.208N>T | p.Ala70Ser | p.A70S | Q8NFL0 | protein_coding | tolerated(0.7) | benign(0.015) | TCGA-AR-A1AV-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
| B3GNT7 | SNV | Missense_Mutation | c.604N>A | p.Asp202Asn | p.D202N | Q8NFL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| B3GNT7 | SNV | Missense_Mutation | rs751482955 | c.884N>T | p.Pro295Leu | p.P295L | Q8NFL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| B3GNT7 | SNV | Missense_Mutation | rs746899567 | c.28N>T | p.Arg10Trp | p.R10W | Q8NFL0 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.518) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| B3GNT7 | SNV | Missense_Mutation | c.151C>T | p.Pro51Ser | p.P51S | Q8NFL0 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| B3GNT7 | SNV | Missense_Mutation | c.917N>T | p.Ala306Val | p.A306V | Q8NFL0 | protein_coding | deleterious(0.03) | possibly_damaging(0.532) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| B3GNT7 | SNV | Missense_Mutation | rs781471024 | c.1136N>T | p.Pro379Leu | p.P379L | Q8NFL0 | protein_coding | tolerated(0.24) | benign(0.051) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| B3GNT7 | SNV | Missense_Mutation | c.604N>A | p.Asp202Asn | p.D202N | Q8NFL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response | ||
| B3GNT7 | SNV | Missense_Mutation | c.397N>A | p.Asp133Asn | p.D133N | Q8NFL0 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| B3GNT7 | SNV | Missense_Mutation | c.818N>T | p.Arg273Leu | p.R273L | Q8NFL0 | protein_coding | tolerated(0.22) | benign(0.386) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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