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Gene: B3GNT6 |
Gene summary for B3GNT6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | B3GNT6 | Gene ID | 192134 |
| Gene name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 | |
| Gene Alias | B3Gn-T6 | |
| Cytomap | 11q13.5 | |
| Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | A8K9Q8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 192134 | B3GNT6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.24e-02 | 3.06e-01 | -0.1808 |
| 192134 | B3GNT6 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.06e-12 | 6.20e-01 | -0.1088 |
| 192134 | B3GNT6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.37e-05 | 1.36e+00 | -0.2196 |
| 192134 | B3GNT6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.97e-14 | 8.28e-01 | -0.1207 |
| 192134 | B3GNT6 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.54e-02 | 3.62e-01 | -0.1526 |
| 192134 | B3GNT6 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.38e-24 | 9.99e-01 | -0.1464 |
| 192134 | B3GNT6 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.04e-12 | 6.48e-01 | -0.1001 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
| GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
| GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
| GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| B3GNT6 | SNV | Missense_Mutation | novel | c.1033N>C | p.Asp345His | p.D345H | Q6ZMB0 | protein_coding | deleterious(0.03) | possibly_damaging(0.874) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| B3GNT6 | SNV | Missense_Mutation | novel | c.1075N>A | p.Ala359Thr | p.A359T | Q6ZMB0 | protein_coding | tolerated(0.13) | possibly_damaging(0.647) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| B3GNT6 | SNV | Missense_Mutation | novel | c.673N>A | p.Val225Met | p.V225M | Q6ZMB0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| B3GNT6 | SNV | Missense_Mutation | c.49N>A | p.Leu17Ile | p.L17I | Q6ZMB0 | protein_coding | deleterious(0.02) | benign(0.14) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| B3GNT6 | SNV | Missense_Mutation | novel | c.22T>C | p.Ser8Pro | p.S8P | Q6ZMB0 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| B3GNT6 | SNV | Missense_Mutation | novel | c.91N>A | p.Leu31Ile | p.L31I | Q6ZMB0 | protein_coding | tolerated(0.08) | benign(0.058) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| B3GNT6 | SNV | Missense_Mutation | novel | c.662G>A | p.Gly221Asp | p.G221D | Q6ZMB0 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| B3GNT6 | SNV | Missense_Mutation | novel | c.717N>T | p.Gln239His | p.Q239H | Q6ZMB0 | protein_coding | tolerated(0.46) | benign(0.005) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| B3GNT6 | SNV | Missense_Mutation | novel | c.527N>T | p.Ala176Val | p.A176V | Q6ZMB0 | protein_coding | tolerated(0.22) | benign(0.338) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| B3GNT6 | SNV | Missense_Mutation | rs782344607 | c.17G>A | p.Arg6His | p.R6H | Q6ZMB0 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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