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Gene: AZIN2 |
Gene summary for AZIN2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | AZIN2 | Gene ID | 113451 |
| Gene name | antizyme inhibitor 2 | |
| Gene Alias | ADC | |
| Cytomap | 1p35.1 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96A70 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 113451 | AZIN2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.75e-03 | 2.34e-01 | -0.1808 |
| 113451 | AZIN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.66e-18 | 7.41e-01 | -0.0811 |
| 113451 | AZIN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.50e-03 | 2.33e-01 | -0.1088 |
| 113451 | AZIN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.39e-17 | 4.84e-01 | -0.1954 |
| 113451 | AZIN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.61e-06 | 3.79e-01 | -0.1464 |
| 113451 | AZIN2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.58e-03 | 2.31e-01 | -0.059 |
| 113451 | AZIN2 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-02 | 3.09e-01 | -0.0842 |
| 113451 | AZIN2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.86e-04 | 5.40e-01 | 0.0131 |
| 113451 | AZIN2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.11e-02 | 2.76e-01 | 0.0588 |
| 113451 | AZIN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.30e-09 | 4.93e-01 | 0.294 |
| 113451 | AZIN2 | A015-C-203 | Human | Colorectum | FAP | 1.35e-02 | -1.36e-01 | -0.1294 |
| 113451 | AZIN2 | A002-C-203 | Human | Colorectum | FAP | 1.16e-02 | -1.57e-01 | 0.2786 |
| 113451 | AZIN2 | A001-C-108 | Human | Colorectum | FAP | 1.15e-04 | -1.74e-01 | -0.0272 |
| 113451 | AZIN2 | A001-C-104 | Human | Colorectum | FAP | 7.27e-04 | -1.77e-01 | 0.0184 |
| 113451 | AZIN2 | A015-C-104 | Human | Colorectum | FAP | 9.56e-07 | -1.84e-01 | -0.1899 |
| 113451 | AZIN2 | A001-C-014 | Human | Colorectum | FAP | 3.10e-04 | -1.62e-01 | 0.0135 |
| 113451 | AZIN2 | A002-C-016 | Human | Colorectum | FAP | 2.31e-04 | -1.64e-01 | 0.0521 |
| 113451 | AZIN2 | A002-C-116 | Human | Colorectum | FAP | 8.47e-04 | -1.62e-01 | -0.0452 |
| 113451 | AZIN2 | F034 | Human | Colorectum | FAP | 8.01e-03 | -1.57e-01 | -0.0665 |
| 113451 | AZIN2 | F072B | Human | Colorectum | FAP | 4.02e-04 | -1.79e-01 | 0.257 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
| GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
| GO:0042177 | Colorectum | AD | negative regulation of protein catabolic process | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
| GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
| GO:00421761 | Colorectum | SER | regulation of protein catabolic process | 126/2897 | 391/18723 | 5.33e-17 | 2.52e-14 | 126 |
| GO:00098951 | Colorectum | SER | negative regulation of catabolic process | 84/2897 | 320/18723 | 3.93e-07 | 2.06e-05 | 84 |
| GO:00421771 | Colorectum | SER | negative regulation of protein catabolic process | 38/2897 | 121/18723 | 8.20e-06 | 2.76e-04 | 38 |
| GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
| GO:00421762 | Colorectum | MSS | regulation of protein catabolic process | 145/3467 | 391/18723 | 2.03e-18 | 1.17e-15 | 145 |
| GO:00098952 | Colorectum | MSS | negative regulation of catabolic process | 110/3467 | 320/18723 | 7.88e-12 | 1.20e-09 | 110 |
| GO:00421772 | Colorectum | MSS | negative regulation of protein catabolic process | 47/3467 | 121/18723 | 1.28e-07 | 6.01e-06 | 47 |
| GO:0034764 | Colorectum | MSS | positive regulation of transmembrane transport | 58/3467 | 219/18723 | 2.19e-03 | 1.83e-02 | 58 |
| GO:0006596 | Colorectum | MSS | polyamine biosynthetic process | 7/3467 | 14/18723 | 7.51e-03 | 4.72e-02 | 7 |
| GO:00421764 | Colorectum | FAP | regulation of protein catabolic process | 106/2622 | 391/18723 | 5.00e-12 | 3.06e-09 | 106 |
| GO:00098954 | Colorectum | FAP | negative regulation of catabolic process | 91/2622 | 320/18723 | 9.66e-12 | 4.96e-09 | 91 |
| GO:00421774 | Colorectum | FAP | negative regulation of protein catabolic process | 38/2622 | 121/18723 | 7.10e-07 | 3.32e-05 | 38 |
| GO:00347641 | Colorectum | FAP | positive regulation of transmembrane transport | 53/2622 | 219/18723 | 3.54e-05 | 7.75e-04 | 53 |
| GO:00421765 | Colorectum | CRC | regulation of protein catabolic process | 87/2078 | 391/18723 | 1.30e-10 | 6.49e-08 | 87 |
| GO:00098955 | Colorectum | CRC | negative regulation of catabolic process | 75/2078 | 320/18723 | 2.02e-10 | 9.31e-08 | 75 |
| GO:00421775 | Colorectum | CRC | negative regulation of protein catabolic process | 33/2078 | 121/18723 | 6.62e-07 | 4.50e-05 | 33 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa00330 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
| hsa003301 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
| hsa003302 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
| hsa003303 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
| hsa003304 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
| hsa003305 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
| hsa003306 | Colorectum | FAP | Arginine and proline metabolism | 16/1404 | 50/8465 | 5.33e-03 | 2.10e-02 | 1.27e-02 | 16 |
| hsa003307 | Colorectum | FAP | Arginine and proline metabolism | 16/1404 | 50/8465 | 5.33e-03 | 2.10e-02 | 1.27e-02 | 16 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| AZIN2 | SNV | Missense_Mutation | rs745840314 | c.1316N>A | p.Arg439Gln | p.R439Q | Q96A70 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | c.806N>A | p.Gly269Asp | p.G269D | Q96A70 | protein_coding | deleterious(0.02) | benign(0.323) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| AZIN2 | SNV | Missense_Mutation | novel | c.5N>T | p.Ala2Val | p.A2V | Q96A70 | protein_coding | tolerated(0.16) | possibly_damaging(0.541) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | novel | c.1252N>C | p.Phe418Leu | p.F418L | Q96A70 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | rs144776558 | c.646G>A | p.Ala216Thr | p.A216T | Q96A70 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | rs144776558 | c.646N>A | p.Ala216Thr | p.A216T | Q96A70 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | novel | c.605N>A | p.Gly202Asp | p.G202D | Q96A70 | protein_coding | tolerated(0.06) | benign(0.046) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| AZIN2 | SNV | Missense_Mutation | rs370531808 | c.841N>A | p.Val281Met | p.V281M | Q96A70 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | rs746470026 | c.1225N>A | p.Ala409Thr | p.A409T | Q96A70 | protein_coding | deleterious(0) | possibly_damaging(0.727) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| AZIN2 | SNV | Missense_Mutation | novel | c.805G>A | p.Gly269Ser | p.G269S | Q96A70 | protein_coding | deleterious(0.02) | possibly_damaging(0.901) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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