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Gene: ATPIF1 |
Gene summary for ATPIF1 |
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Gene information | Species | Human | Gene symbol | ATPIF1 | Gene ID | 93974 |
Gene name | ATP synthase inhibitory factor subunit 1 | |
Gene Alias | ATPI | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0000422 | UniProtAcc | Q9UII2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93974 | ATPIF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.49e-74 | 1.52e+00 | 0.294 |
93974 | ATPIF1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.08e-20 | 1.54e+00 | 0.3487 |
93974 | ATPIF1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.45e-48 | 1.18e+00 | 0.281 |
93974 | ATPIF1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.71e-81 | 1.50e+00 | 0.3859 |
93974 | ATPIF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.31e-21 | 7.20e-01 | 0.2585 |
93974 | ATPIF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.78e-48 | 8.63e-01 | 0.3005 |
93974 | ATPIF1 | AEH-subject1 | Human | Endometrium | AEH | 1.05e-105 | -1.09e+00 | -0.3059 |
93974 | ATPIF1 | AEH-subject2 | Human | Endometrium | AEH | 1.10e-87 | -1.09e+00 | -0.2525 |
93974 | ATPIF1 | AEH-subject3 | Human | Endometrium | AEH | 1.79e-106 | -1.09e+00 | -0.2576 |
93974 | ATPIF1 | AEH-subject4 | Human | Endometrium | AEH | 7.58e-71 | -1.09e+00 | -0.2657 |
93974 | ATPIF1 | AEH-subject5 | Human | Endometrium | AEH | 1.79e-106 | -1.09e+00 | -0.2953 |
93974 | ATPIF1 | EEC-subject1 | Human | Endometrium | EEC | 1.34e-97 | -1.09e+00 | -0.2682 |
93974 | ATPIF1 | EEC-subject2 | Human | Endometrium | EEC | 1.11e-102 | -1.09e+00 | -0.2607 |
93974 | ATPIF1 | EEC-subject3 | Human | Endometrium | EEC | 6.10e-102 | -1.09e+00 | -0.2525 |
93974 | ATPIF1 | EEC-subject4 | Human | Endometrium | EEC | 3.32e-101 | -1.09e+00 | -0.2571 |
93974 | ATPIF1 | EEC-subject5 | Human | Endometrium | EEC | 3.50e-104 | -1.09e+00 | -0.249 |
93974 | ATPIF1 | GSM5276934 | Human | Endometrium | EEC | 3.50e-104 | -1.09e+00 | -0.0913 |
93974 | ATPIF1 | GSM5276935 | Human | Endometrium | EEC | 1.11e-102 | -1.09e+00 | -0.123 |
93974 | ATPIF1 | GSM5276937 | Human | Endometrium | EEC | 2.63e-83 | -1.09e+00 | -0.0897 |
93974 | ATPIF1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.49e-74 | -1.09e+00 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATPIF1 | SNV | Missense_Mutation | novel | c.5N>G | p.Ala2Gly | p.A2G | Q9UII2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ATPIF1 | insertion | Frame_Shift_Ins | novel | c.129_130insTCTATCTATATGGATTTACCTATTCT | p.Gly44SerfsTer36 | p.G44Sfs*36 | Q9UII2 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
ATPIF1 | SNV | Missense_Mutation | c.124N>A | p.Glu42Lys | p.E42K | Q9UII2 | protein_coding | deleterious(0) | benign(0.432) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATPIF1 | SNV | Missense_Mutation | c.160G>A | p.Glu54Lys | p.E54K | Q9UII2 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATPIF1 | SNV | Missense_Mutation | c.136G>T | p.Ala46Ser | p.A46S | Q9UII2 | protein_coding | tolerated(0.11) | benign(0.312) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATPIF1 | SNV | Missense_Mutation | rs374584642 | c.280N>T | p.Arg94Cys | p.R94C | Q9UII2 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATPIF1 | SNV | Missense_Mutation | rs754730947 | c.244N>C | p.Lys82Gln | p.K82Q | Q9UII2 | protein_coding | tolerated(0.21) | benign(0.081) | TCGA-44-2659-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | alimta | PD |
ATPIF1 | SNV | Missense_Mutation | rs780836240 | c.246N>T | p.Lys82Asn | p.K82N | Q9UII2 | protein_coding | tolerated(0.06) | benign(0.343) | TCGA-44-2659-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | alimta | PD |
ATPIF1 | SNV | Missense_Mutation | novel | c.243N>A | p.His81Gln | p.H81Q | Q9UII2 | protein_coding | deleterious(0.03) | probably_damaging(0.953) | TCGA-21-1082-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATPIF1 | SNV | Missense_Mutation | c.142G>C | p.Gly48Arg | p.G48R | Q9UII2 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-CG-4469-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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