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Gene: ATPAF1 |
Gene summary for ATPAF1 |
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Gene information | Species | Human | Gene symbol | ATPAF1 | Gene ID | 64756 |
Gene name | ATP synthase mitochondrial F1 complex assembly factor 1 | |
Gene Alias | ATP11 | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A8MRA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64756 | ATPAF1 | LZE2T | Human | Esophagus | ESCC | 1.66e-04 | 6.22e-01 | 0.082 |
64756 | ATPAF1 | LZE4T | Human | Esophagus | ESCC | 4.81e-04 | 4.73e-02 | 0.0811 |
64756 | ATPAF1 | LZE20T | Human | Esophagus | ESCC | 2.36e-03 | 2.08e-01 | 0.0662 |
64756 | ATPAF1 | LZE24T | Human | Esophagus | ESCC | 1.60e-13 | 3.71e-01 | 0.0596 |
64756 | ATPAF1 | P1T-E | Human | Esophagus | ESCC | 1.18e-06 | 4.67e-01 | 0.0875 |
64756 | ATPAF1 | P2T-E | Human | Esophagus | ESCC | 2.41e-36 | 6.07e-01 | 0.1177 |
64756 | ATPAF1 | P4T-E | Human | Esophagus | ESCC | 4.45e-23 | 6.08e-01 | 0.1323 |
64756 | ATPAF1 | P5T-E | Human | Esophagus | ESCC | 6.54e-27 | 4.47e-01 | 0.1327 |
64756 | ATPAF1 | P8T-E | Human | Esophagus | ESCC | 3.65e-21 | 3.27e-01 | 0.0889 |
64756 | ATPAF1 | P9T-E | Human | Esophagus | ESCC | 1.20e-13 | 3.11e-01 | 0.1131 |
64756 | ATPAF1 | P10T-E | Human | Esophagus | ESCC | 8.49e-55 | 8.92e-01 | 0.116 |
64756 | ATPAF1 | P11T-E | Human | Esophagus | ESCC | 1.40e-06 | 3.42e-01 | 0.1426 |
64756 | ATPAF1 | P12T-E | Human | Esophagus | ESCC | 4.59e-19 | 3.36e-01 | 0.1122 |
64756 | ATPAF1 | P15T-E | Human | Esophagus | ESCC | 7.27e-19 | 4.39e-01 | 0.1149 |
64756 | ATPAF1 | P16T-E | Human | Esophagus | ESCC | 1.13e-18 | 3.16e-01 | 0.1153 |
64756 | ATPAF1 | P17T-E | Human | Esophagus | ESCC | 2.75e-06 | 2.11e-01 | 0.1278 |
64756 | ATPAF1 | P19T-E | Human | Esophagus | ESCC | 9.02e-10 | 5.75e-01 | 0.1662 |
64756 | ATPAF1 | P20T-E | Human | Esophagus | ESCC | 4.04e-24 | 4.93e-01 | 0.1124 |
64756 | ATPAF1 | P21T-E | Human | Esophagus | ESCC | 5.53e-34 | 5.82e-01 | 0.1617 |
64756 | ATPAF1 | P22T-E | Human | Esophagus | ESCC | 3.86e-21 | 3.30e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00700711 | Esophagus | ESCC | proton-transporting two-sector ATPase complex assembly | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:0070071 | Liver | HCC | proton-transporting two-sector ATPase complex assembly | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:00700712 | Thyroid | PTC | proton-transporting two-sector ATPase complex assembly | 11/5968 | 15/18723 | 1.19e-03 | 6.84e-03 | 11 |
GO:007007111 | Thyroid | ATC | proton-transporting two-sector ATPase complex assembly | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATPAF1 | SNV | Missense_Mutation | c.418N>A | p.Asp140Asn | p.D140N | protein_coding | deleterious(0.04) | benign(0.113) | TCGA-BH-A18F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | ||
ATPAF1 | insertion | Nonsense_Mutation | novel | c.1031_1032insATTC | p.Cys344Ter | p.C344* | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
ATPAF1 | insertion | In_Frame_Ins | novel | c.1029_1030insCCTCTACCTCCCTGGTTCAAG | p.Lys343_Cys344insProLeuProProTrpPheLys | p.K343_C344insPLPPWFK | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
ATPAF1 | SNV | Missense_Mutation | novel | c.706N>G | p.Gln236Glu | p.Q236E | protein_coding | deleterious(0.03) | possibly_damaging(0.628) | TCGA-ZJ-AB0I-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ATPAF1 | SNV | Missense_Mutation | c.986N>C | p.Val329Ala | p.V329A | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ATPAF1 | SNV | Missense_Mutation | c.637N>T | p.Arg213Trp | p.R213W | protein_coding | deleterious(0.02) | possibly_damaging(0.555) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ATPAF1 | SNV | Missense_Mutation | novel | c.561T>G | p.Ile187Met | p.I187M | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATPAF1 | SNV | Missense_Mutation | novel | c.824N>C | p.Ile275Thr | p.I275T | protein_coding | deleterious(0.02) | possibly_damaging(0.603) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ATPAF1 | SNV | Missense_Mutation | rs755925763 | c.638G>A | p.Arg213Gln | p.R213Q | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-AJ-A3NC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATPAF1 | SNV | Missense_Mutation | novel | c.847G>A | p.Asp283Asn | p.D283N | protein_coding | deleterious(0.03) | possibly_damaging(0.833) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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