Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ATP6V1E1

Gene summary for ATP6V1E1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ATP6V1E1

Gene ID

529

Gene nameATPase H+ transporting V1 subunit E1
Gene AliasARCL2C
Cytomap22q11.21
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

P36543


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
529ATP6V1E1HTA11_3410_2000001011HumanColorectumAD3.29e-027.66e-020.0155
529ATP6V1E1HTA11_2487_2000001011HumanColorectumSER1.00e-073.66e-01-0.1808
529ATP6V1E1HTA11_1938_2000001011HumanColorectumAD3.03e-064.15e-01-0.0811
529ATP6V1E1HTA11_78_2000001011HumanColorectumAD1.40e-063.76e-01-0.1088
529ATP6V1E1HTA11_347_2000001011HumanColorectumAD2.21e-164.68e-01-0.1954
529ATP6V1E1HTA11_411_2000001011HumanColorectumSER1.05e-048.49e-01-0.2602
529ATP6V1E1HTA11_3361_2000001011HumanColorectumAD1.88e-063.18e-01-0.1207
529ATP6V1E1HTA11_696_2000001011HumanColorectumAD6.94e-033.18e-01-0.1464
529ATP6V1E1HTA11_1391_2000001011HumanColorectumAD2.16e-064.65e-01-0.059
529ATP6V1E1HTA11_5212_2000001011HumanColorectumAD1.05e-024.45e-01-0.2061
529ATP6V1E1HTA11_546_2000001011HumanColorectumAD1.24e-022.54e-01-0.0842
529ATP6V1E1HTA11_99999970781_79442HumanColorectumMSS1.12e-043.79e-010.294
529ATP6V1E1HTA11_99999965104_69814HumanColorectumMSS1.04e-104.89e-010.281
529ATP6V1E1HTA11_99999971662_82457HumanColorectumMSS5.93e-085.12e-010.3859
529ATP6V1E1HTA11_99999973899_84307HumanColorectumMSS7.37e-042.24e-010.2585
529ATP6V1E1A015-C-203HumanColorectumFAP3.66e-02-1.18e-01-0.1294
529ATP6V1E1A015-C-104HumanColorectumFAP4.01e-03-8.09e-02-0.1899
529ATP6V1E1A002-C-116HumanColorectumFAP1.95e-02-5.70e-02-0.0452
529ATP6V1E1LZE4THumanEsophagusESCC3.13e-164.84e-010.0811
529ATP6V1E1LZE5THumanEsophagusESCC2.66e-044.35e-010.0514
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:1902600ColorectumADproton transmembrane transport66/3918157/187231.59e-091.17e-0766
GO:0010506ColorectumADregulation of autophagy111/3918317/187233.57e-092.35e-07111
GO:0016236ColorectumADmacroautophagy103/3918291/187236.76e-094.15e-07103
GO:0016241ColorectumADregulation of macroautophagy50/3918141/187234.55e-057.92e-0450
GO:19026001ColorectumSERproton transmembrane transport60/2897157/187233.12e-127.08e-1060
GO:00162361ColorectumSERmacroautophagy79/2897291/187231.97e-071.10e-0579
GO:00105061ColorectumSERregulation of autophagy74/2897317/187231.39e-042.77e-0374
GO:00162411ColorectumSERregulation of macroautophagy34/2897141/187234.74e-033.72e-0234
GO:00162362ColorectumMSSmacroautophagy93/3467291/187232.08e-081.17e-0693
GO:19026002ColorectumMSSproton transmembrane transport57/3467157/187231.00e-074.81e-0657
GO:00105062ColorectumMSSregulation of autophagy95/3467317/187234.36e-071.71e-0595
GO:00162412ColorectumMSSregulation of macroautophagy44/3467141/187231.88e-042.64e-0344
GO:00105063ColorectumFAPregulation of autophagy80/2622317/187236.43e-084.54e-0680
GO:00162363ColorectumFAPmacroautophagy70/2622291/187232.73e-061.02e-0470
GO:00162413ColorectumFAPregulation of macroautophagy38/2622141/187233.78e-058.13e-0438
GO:19026004ColorectumFAPproton transmembrane transport39/2622157/187232.03e-042.92e-0339
GO:001050616EsophagusHGINregulation of autophagy84/2587317/187231.39e-091.08e-0784
GO:001623616EsophagusHGINmacroautophagy77/2587291/187237.15e-094.61e-0777
GO:190260017EsophagusHGINproton transmembrane transport43/2587157/187235.51e-061.75e-0443
GO:00162418EsophagusHGINregulation of macroautophagy38/2587141/187232.80e-057.21e-0438
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa00190ColorectumADOxidative phosphorylation86/2092134/84652.47e-222.76e-201.76e-2086
hsa05110ColorectumADVibrio cholerae infection29/209250/84655.10e-077.12e-064.54e-0629
hsa001901ColorectumADOxidative phosphorylation86/2092134/84652.47e-222.76e-201.76e-2086
hsa051101ColorectumADVibrio cholerae infection29/209250/84655.10e-077.12e-064.54e-0629
hsa001902ColorectumSEROxidative phosphorylation79/1580134/84651.98e-251.64e-231.19e-2379
hsa051102ColorectumSERVibrio cholerae infection24/158050/84652.17e-063.13e-052.28e-0524
hsa001903ColorectumSEROxidative phosphorylation79/1580134/84651.98e-251.64e-231.19e-2379
hsa051103ColorectumSERVibrio cholerae infection24/158050/84652.17e-063.13e-052.28e-0524
hsa001904ColorectumMSSOxidative phosphorylation79/1875134/84651.89e-207.90e-194.84e-1979
hsa051104ColorectumMSSVibrio cholerae infection27/187550/84658.58e-071.20e-057.34e-0627
hsa04150ColorectumMSSmTOR signaling pathway47/1875156/84651.19e-023.99e-022.44e-0247
hsa001905ColorectumMSSOxidative phosphorylation79/1875134/84651.89e-207.90e-194.84e-1979
hsa051105ColorectumMSSVibrio cholerae infection27/187550/84658.58e-071.20e-057.34e-0627
hsa041501ColorectumMSSmTOR signaling pathway47/1875156/84651.19e-023.99e-022.44e-0247
hsa001908ColorectumFAPOxidative phosphorylation44/1404134/84652.56e-064.28e-052.60e-0544
hsa051108ColorectumFAPVibrio cholerae infection19/140450/84652.24e-041.92e-031.17e-0319
hsa001909ColorectumFAPOxidative phosphorylation44/1404134/84652.56e-064.28e-052.60e-0544
hsa051109ColorectumFAPVibrio cholerae infection19/140450/84652.24e-041.92e-031.17e-0319
hsa0019030EsophagusHGINOxidative phosphorylation68/1383134/84651.73e-208.07e-196.41e-1968
hsa00190113EsophagusHGINOxidative phosphorylation68/1383134/84651.73e-208.07e-196.41e-1968
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ATP6V1E1SNVMissense_Mutationnovelc.640G>Tp.Ala214Serp.A214SP36543protein_codingtolerated(0.12)benign(0.014)TCGA-D8-A27M-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapymethotrexate+5SD
ATP6V1E1SNVMissense_Mutationnovelc.562N>Tp.Arg188Cysp.R188CP36543protein_codingdeleterious(0.03)benign(0.022)TCGA-E9-A22G-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
ATP6V1E1SNVMissense_Mutationnovelc.17N>Tp.Ala6Valp.A6VP36543protein_codingtolerated(0.22)benign(0.007)TCGA-VS-A94Z-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ATP6V1E1SNVMissense_Mutationnovelc.562N>Tp.Arg188Cysp.R188CP36543protein_codingdeleterious(0.03)benign(0.022)TCGA-AA-3495-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ATP6V1E1SNVMissense_Mutationc.202N>Gp.Lys68Glup.K68EP36543protein_codingdeleterious(0)benign(0.394)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
ATP6V1E1SNVMissense_Mutationnovelc.562N>Ap.Arg188Serp.R188SP36543protein_codingtolerated(0.11)benign(0.03)TCGA-D5-6530-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
ATP6V1E1SNVMissense_Mutationc.228G>Ap.Met76Ilep.M76IP36543protein_codingtolerated(0.17)benign(0.012)TCGA-AJ-A23M-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapyunknownPD
ATP6V1E1SNVMissense_Mutationrs144829775c.392G>Ap.Arg131Glnp.R131QP36543protein_codingtolerated(0.48)benign(0)TCGA-AP-A056-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
ATP6V1E1SNVMissense_Mutationnovelc.545A>Tp.Glu182Valp.E182VP36543protein_codingdeleterious(0.04)benign(0.145)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
ATP6V1E1SNVMissense_Mutationc.27A>Cp.Gln9Hisp.Q9HP36543protein_codingdeleterious(0.02)benign(0.443)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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