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Gene: ATP6V0A4 |
Gene summary for ATP6V0A4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ATP6V0A4 | Gene ID | 50617 |
| Gene name | ATPase H+ transporting V0 subunit a4 | |
| Gene Alias | A4 | |
| Cytomap | 7q34 | |
| Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | A0A024R791 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 50617 | ATP6V0A4 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.04e-20 | 6.71e-01 | -0.0166 |
| 50617 | ATP6V0A4 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.02e-23 | 7.02e-01 | -0.0132 |
| 50617 | ATP6V0A4 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.59e-26 | 7.42e-01 | -0.013 |
| 50617 | ATP6V0A4 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 7.00e-18 | 6.40e-01 | -0.0121 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa051656 | Lung | IAC | Human papillomavirus infection | 71/1053 | 331/8465 | 1.88e-06 | 7.63e-05 | 5.06e-05 | 71 |
| hsa0516511 | Lung | IAC | Human papillomavirus infection | 71/1053 | 331/8465 | 1.88e-06 | 7.63e-05 | 5.06e-05 | 71 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ATP6V0A4 | SNV | Missense_Mutation | novel | c.2299N>G | p.Leu767Val | p.L767V | Q9HBG4 | protein_coding | deleterious(0.01) | possibly_damaging(0.832) | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ATP6V0A4 | SNV | Missense_Mutation | novel | c.1170G>T | p.Glu390Asp | p.E390D | Q9HBG4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ATP6V0A4 | SNV | Missense_Mutation | c.838N>G | p.His280Asp | p.H280D | Q9HBG4 | protein_coding | deleterious(0.01) | benign(0.345) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| ATP6V0A4 | insertion | Frame_Shift_Ins | novel | c.2012_2013insC | p.Gln672AlafsTer11 | p.Q672Afs*11 | Q9HBG4 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| ATP6V0A4 | insertion | In_Frame_Ins | novel | c.2011_2012insCACTGCATTCGCATAAACGATCAGGTGTGG | p.Leu671delinsProLeuHisSerHisLysArgSerGlyValVal | p.L671delinsPLHSHKRSGVV | Q9HBG4 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| ATP6V0A4 | insertion | Frame_Shift_Ins | novel | c.1949_1950insACTCTGTCCCCCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTG | p.Val651LeufsTer22 | p.V651Lfs*22 | Q9HBG4 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ATP6V0A4 | SNV | Missense_Mutation | novel | c.106N>A | p.Gln36Lys | p.Q36K | Q9HBG4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ATP6V0A4 | SNV | Missense_Mutation | novel | c.49C>T | p.Leu17Phe | p.L17F | Q9HBG4 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
| ATP6V0A4 | SNV | Missense_Mutation | c.1891N>A | p.Pro631Thr | p.P631T | Q9HBG4 | protein_coding | tolerated(0.42) | probably_damaging(0.99) | TCGA-LP-A5U3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ATP6V0A4 | SNV | Missense_Mutation | rs748712784 | c.559C>T | p.Arg187Trp | p.R187W | Q9HBG4 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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