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Gene: ATP5S |
Gene summary for ATP5S |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ATP5S | Gene ID | 27109 |
| Gene name | distal membrane arm assembly component 2 like | |
| Gene Alias | ATP5S | |
| Cytomap | 14q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q99766 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 27109 | ATP5S | P1T-E | Human | Esophagus | ESCC | 8.36e-09 | 3.18e-01 | 0.0875 |
| 27109 | ATP5S | P2T-E | Human | Esophagus | ESCC | 4.47e-20 | 4.49e-01 | 0.1177 |
| 27109 | ATP5S | P4T-E | Human | Esophagus | ESCC | 8.21e-16 | 5.75e-01 | 0.1323 |
| 27109 | ATP5S | P5T-E | Human | Esophagus | ESCC | 5.99e-18 | 2.23e-01 | 0.1327 |
| 27109 | ATP5S | P8T-E | Human | Esophagus | ESCC | 2.20e-19 | 3.51e-01 | 0.0889 |
| 27109 | ATP5S | P9T-E | Human | Esophagus | ESCC | 3.78e-20 | 3.66e-01 | 0.1131 |
| 27109 | ATP5S | P10T-E | Human | Esophagus | ESCC | 1.34e-22 | 5.04e-01 | 0.116 |
| 27109 | ATP5S | P11T-E | Human | Esophagus | ESCC | 6.57e-07 | 2.79e-01 | 0.1426 |
| 27109 | ATP5S | P12T-E | Human | Esophagus | ESCC | 1.58e-27 | 5.92e-01 | 0.1122 |
| 27109 | ATP5S | P15T-E | Human | Esophagus | ESCC | 3.45e-37 | 8.90e-01 | 0.1149 |
| 27109 | ATP5S | P16T-E | Human | Esophagus | ESCC | 4.73e-19 | 4.44e-01 | 0.1153 |
| 27109 | ATP5S | P17T-E | Human | Esophagus | ESCC | 4.59e-12 | 4.63e-01 | 0.1278 |
| 27109 | ATP5S | P20T-E | Human | Esophagus | ESCC | 4.30e-18 | 3.86e-01 | 0.1124 |
| 27109 | ATP5S | P21T-E | Human | Esophagus | ESCC | 1.32e-19 | 4.08e-01 | 0.1617 |
| 27109 | ATP5S | P22T-E | Human | Esophagus | ESCC | 7.21e-24 | 4.20e-01 | 0.1236 |
| 27109 | ATP5S | P23T-E | Human | Esophagus | ESCC | 2.85e-18 | 4.35e-01 | 0.108 |
| 27109 | ATP5S | P24T-E | Human | Esophagus | ESCC | 6.41e-27 | 6.32e-01 | 0.1287 |
| 27109 | ATP5S | P26T-E | Human | Esophagus | ESCC | 6.23e-27 | 5.44e-01 | 0.1276 |
| 27109 | ATP5S | P27T-E | Human | Esophagus | ESCC | 4.09e-21 | 5.49e-01 | 0.1055 |
| 27109 | ATP5S | P28T-E | Human | Esophagus | ESCC | 3.61e-12 | 2.40e-01 | 0.1149 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ATP5S | SNV | Missense_Mutation | c.230T>C | p.Val77Ala | p.V77A | Q99766 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ATP5S | SNV | Missense_Mutation | novel | c.250N>G | p.Arg84Gly | p.R84G | Q99766 | protein_coding | deleterious(0) | possibly_damaging(0.567) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
| ATP5S | SNV | Missense_Mutation | novel | c.103T>C | p.Ser35Pro | p.S35P | Q99766 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| ATP5S | SNV | Missense_Mutation | novel | c.563T>G | p.Leu188Arg | p.L188R | Q99766 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| ATP5S | SNV | Missense_Mutation | novel | c.293A>G | p.Asp98Gly | p.D98G | Q99766 | protein_coding | tolerated(0.8) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ATP5S | SNV | Missense_Mutation | novel | c.401G>A | p.Cys134Tyr | p.C134Y | Q99766 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| ATP5S | SNV | Missense_Mutation | rs112164857 | c.589N>A | p.Leu197Ile | p.L197I | Q99766 | protein_coding | tolerated(0.8) | benign(0.001) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| ATP5S | SNV | Missense_Mutation | rs755906483 | c.167G>A | p.Arg56His | p.R56H | Q99766 | protein_coding | deleterious(0.02) | possibly_damaging(0.875) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ATP5S | SNV | Missense_Mutation | novel | c.94N>T | p.Leu32Phe | p.L32F | Q99766 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ATP5S | SNV | Missense_Mutation | novel | c.518N>T | p.Ala173Val | p.A173V | Q99766 | protein_coding | deleterious(0.03) | possibly_damaging(0.883) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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