Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ATP1A2

Gene summary for ATP1A2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ATP1A2

Gene ID

477

Gene nameATPase Na+/K+ transporting subunit alpha 2
Gene AliasFHM2
Cytomap1q23.2
Gene Typeprotein-coding
GO ID

GO:0001504

UniProtAcc

A0A0S2Z3W6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
477ATP1A2HCC1HumanLiverHCC3.57e-072.68e+000.5336
477ATP1A2HCC2HumanLiverHCC4.91e-151.23e+000.5341
477ATP1A2HCC5HumanLiverHCC1.24e-047.57e-010.4932
477ATP1A2S014HumanLiverHCC2.73e-095.21e-010.2254
477ATP1A2S015HumanLiverHCC1.80e-108.67e-010.2375
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004603422LiverHCCATP metabolic process198/7958277/187238.30e-231.55e-20198
GO:004854522LiverHCCresponse to steroid hormone206/7958339/187236.81e-122.92e-10206
GO:007149622LiverHCCcellular response to external stimulus191/7958320/187233.40e-101.13e-08191
GO:007138322LiverHCCcellular response to steroid hormone stimulus128/7958204/187233.92e-091.04e-07128
GO:003297022LiverHCCregulation of actin filament-based process222/7958397/187233.81e-088.30e-07222
GO:001631121LiverHCCdephosphorylation230/7958417/187231.00e-071.96e-06230
GO:005123521LiverHCCmaintenance of location185/7958327/187231.70e-073.12e-06185
GO:007121421LiverHCCcellular response to abiotic stimulus183/7958331/187231.59e-062.26e-05183
GO:010400421LiverHCCcellular response to environmental stimulus183/7958331/187231.59e-062.26e-05183
GO:005165112LiverHCCmaintenance of location in cell119/7958214/187237.11e-056.39e-04119
GO:19026007LiverHCCproton transmembrane transport87/7958157/187237.27e-044.42e-0387
GO:00712601LiverHCCcellular response to mechanical stimulus48/795881/187231.72e-038.96e-0348
GO:00096124LiverHCCresponse to mechanical stimulus113/7958216/187232.20e-031.10e-02113
GO:00093146LiverHCCresponse to radiation223/7958456/187233.08e-031.43e-02223
GO:015010411LiverHCCtransport across blood-brain barrier50/795887/187233.42e-031.55e-0250
GO:001023211LiverHCCvascular transport50/795888/187234.69e-032.02e-0250
GO:00551191LiverHCCrelaxation of cardiac muscle13/795817/187234.77e-032.02e-0213
GO:00860642LiverHCCcell communication by electrical coupling involved in cardiac conduction17/795825/187238.94e-033.45e-0217
GO:0010882LiverHCCregulation of cardiac muscle contraction by calcium ion signaling18/795827/187239.75e-033.66e-0218
GO:0010881LiverHCCregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion15/795822/187231.35e-024.80e-0215
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0491912LiverHCCThyroid hormone signaling pathway75/4020121/84658.76e-043.38e-031.88e-0375
hsa0491913LiverHCCThyroid hormone signaling pathway75/4020121/84658.76e-043.38e-031.88e-0375
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ATP1A2SNVMissense_Mutationc.144G>Tp.Glu48Aspp.E48DP50993protein_codingtolerated(0.16)benign(0.029)TCGA-A2-A25A-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificCytoxanSD
ATP1A2SNVMissense_Mutationrs755353911c.1529N>Ap.Arg510Hisp.R510HP50993protein_codingdeleterious(0.01)probably_damaging(1)TCGA-A8-A09I-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
ATP1A2SNVMissense_Mutationc.2996N>Tp.Asp999Valp.D999VP50993protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ATP1A2SNVMissense_Mutationc.1079N>Gp.Glu360Glyp.E360GP50993protein_codingdeleterious(0.01)probably_damaging(1)TCGA-AQ-A04J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
ATP1A2SNVMissense_Mutationnovelc.1055A>Gp.Lys352Argp.K352RP50993protein_codingdeleterious(0.03)probably_damaging(0.999)TCGA-AR-A1AM-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinSD
ATP1A2SNVMissense_Mutationc.250A>Gp.Thr84Alap.T84AP50993protein_codingdeleterious(0.01)possibly_damaging(0.577)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ATP1A2SNVMissense_Mutationrs768136835c.713N>Ap.Arg238Hisp.R238HP50993protein_codingdeleterious(0)benign(0.071)TCGA-E2-A14U-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ATP1A2insertionFrame_Shift_Insnovelc.2921_2922insATCTATAATGAAACCACCACCAGGAACTGTGGGAGATGCTGAGAp.Leu975SerfsTer102p.L975Sfs*102P50993protein_codingTCGA-A8-A06Q-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
ATP1A2insertionNonsense_Mutationnovelc.964_965insACTGAGACTp.Leu322delinsHisTerAspPhep.L322delinsH*DFP50993protein_codingTCGA-A8-A090-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ATP1A2insertionIn_Frame_Insnovelc.1799_1800insTTCCCAAGCCTCTGCGGCATCCCTGGGGTGp.Val600_Gly601insSerGlnAlaSerAlaAlaSerLeuGlyTrpp.V600_G601insSQASAASLGWP50993protein_codingTCGA-BH-A0B8-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
477ATP1A2ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOMEolanzapineOLANZAPINE
477ATP1A2ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOMEinhibitorCHEMBL3545057ACETYLDIGITOXIN
477ATP1A2ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOMEinhibitorCHEMBL254219DIGITOXIN
477ATP1A2ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOMEinhibitorCHEMBL1751DIGOXIN
477ATP1A2ENZYME, TRANSPORTER, ION CHANNEL, DRUGGABLE GENOMEinhibitorCHEMBL1614DESLANOSIDE
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