|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: ATOH1 |
Gene summary for ATOH1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ATOH1 | Gene ID | 474 |
| Gene name | atonal bHLH transcription factor 1 | |
| Gene Alias | ATH1 | |
| Cytomap | 4q22.2 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q92858 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 474 | ATOH1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.02e-08 | 3.43e-01 | -0.1088 |
| 474 | ATOH1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.56e-07 | 2.53e-01 | -0.1464 |
| 474 | ATOH1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.38e-06 | 2.54e-01 | -0.1001 |
| 474 | ATOH1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.63e-02 | 2.35e-01 | -0.059 |
| 474 | ATOH1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.89e-03 | 4.77e-01 | 0.3487 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
| GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
| GO:0035315 | Colorectum | AD | hair cell differentiation | 21/3918 | 47/18723 | 2.14e-04 | 2.82e-03 | 21 |
| GO:0042491 | Colorectum | AD | inner ear auditory receptor cell differentiation | 17/3918 | 38/18723 | 8.26e-04 | 8.13e-03 | 17 |
| GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
| GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
| GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
| GO:0007411 | Colorectum | AD | axon guidance | 64/3918 | 227/18723 | 5.41e-03 | 3.55e-02 | 64 |
| GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
| GO:0097485 | Colorectum | AD | neuron projection guidance | 64/3918 | 228/18723 | 6.02e-03 | 3.78e-02 | 64 |
| GO:0007219 | Colorectum | AD | Notch signaling pathway | 50/3918 | 172/18723 | 6.92e-03 | 4.26e-02 | 50 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ATOH1 | IMGOB | Colorectum | AD | CLCA1,KCNMA1,TFF3, etc. | 2.02e-01 |  |
| ATOH1 | GOB | Colorectum | AD | CLCA1,KCNMA1,TFF3, etc. | 2.32e-01 | |
| ATOH1 | GOB | Colorectum | ADJ | REP15,CAPN9,ANO7, etc. | 2.82e-01 |  |
| ATOH1 | IMGOB | Colorectum | ADJ | REP15,CAPN9,ANO7, etc. | 1.27e-01 | |
| ATOH1 | IMGOB | Colorectum | FAP | REP15,CAPN9,ANO7, etc. | 2.37e-01 |  |
| ATOH1 | GOB | Colorectum | FAP | REP15,CAPN9,ANO7, etc. | 1.21e-01 | |
| ATOH1 | GOB | Colorectum | Healthy | SYTL2,CAPN9,BCAS1, etc. | 2.91e-01 |  |
| ATOH1 | GOB | Colorectum | MSI-H | CLCA1,KCNMA1,TFF3, etc. | 4.32e-01 |  |
| ATOH1 | IMGOB | Colorectum | MSI-H | CLCA1,KCNMA1,TFF3, etc. | 2.53e-01 | |
| ATOH1 | IMGOB | Colorectum | MSS | CLCA1,KCNMA1,TFF3, etc. | 6.91e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ATOH1 | SNV | Missense_Mutation | c.766N>A | p.Ala256Thr | p.A256T | Q92858 | protein_coding | tolerated(0.41) | benign(0) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ATOH1 | SNV | Missense_Mutation | c.571N>C | p.Asn191His | p.N191H | Q92858 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| ATOH1 | SNV | Missense_Mutation | c.5N>T | p.Ser2Phe | p.S2F | Q92858 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.737) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| ATOH1 | SNV | Missense_Mutation | c.992N>T | p.Ser331Leu | p.S331L | Q92858 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C8-A12W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| ATOH1 | SNV | Missense_Mutation | rs139664764 | c.659G>A | p.Gly220Glu | p.G220E | Q92858 | protein_coding | tolerated(0.08) | benign(0.022) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| ATOH1 | SNV | Missense_Mutation | c.251N>T | p.Ser84Phe | p.S84F | Q92858 | protein_coding | deleterious(0) | benign(0.384) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ATOH1 | SNV | Missense_Mutation | c.931N>G | p.Leu311Val | p.L311V | Q92858 | protein_coding | tolerated(0.15) | benign(0.351) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| ATOH1 | SNV | Missense_Mutation | rs772119264 | c.104N>A | p.Pro35Gln | p.P35Q | Q92858 | protein_coding | tolerated_low_confidence(0.3) | benign(0.308) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
| ATOH1 | SNV | Missense_Mutation | novel | c.527N>G | p.Asn176Ser | p.N176S | Q92858 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ATOH1 | SNV | Missense_Mutation | novel | c.311N>G | p.Glu104Gly | p.E104G | Q92858 | protein_coding | deleterious(0.02) | benign(0.081) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |