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Gene: ATG10 |
Gene summary for ATG10 |
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Gene information | Species | Human | Gene symbol | ATG10 | Gene ID | 83734 |
Gene name | autophagy related 10 | |
Gene Alias | APG10 | |
Cytomap | 5q14.1-q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9H0Y0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83734 | ATG10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.18e-33 | 9.18e-01 | 0.0155 |
83734 | ATG10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.74e-22 | 1.40e+00 | -0.1808 |
83734 | ATG10 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.14e-04 | 7.74e-01 | 0.0216 |
83734 | ATG10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.48e-33 | 1.88e+00 | -0.0811 |
83734 | ATG10 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.72e-21 | 1.19e+00 | -0.1088 |
83734 | ATG10 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.89e-45 | 1.54e+00 | -0.1954 |
83734 | ATG10 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.39e-14 | 1.66e+00 | -0.2602 |
83734 | ATG10 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.98e-04 | 1.39e+00 | -0.2196 |
83734 | ATG10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.51e-14 | 1.39e+00 | -0.1207 |
83734 | ATG10 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.05e-21 | 1.53e+00 | -0.1526 |
83734 | ATG10 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.25e-34 | 1.48e+00 | -0.1464 |
83734 | ATG10 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.28e-17 | 9.20e-01 | -0.1001 |
83734 | ATG10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.60e-39 | 2.06e+00 | -0.059 |
83734 | ATG10 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.68e-15 | 1.40e+00 | -0.1706 |
83734 | ATG10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.20e-11 | 1.04e+00 | -0.2061 |
83734 | ATG10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.50e-16 | 1.71e+00 | -0.1462 |
83734 | ATG10 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.99e-14 | 1.19e+00 | -0.0842 |
83734 | ATG10 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.93e-12 | 1.20e+00 | -0.00410000000000005 |
83734 | ATG10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.61e-11 | 8.90e-01 | -0.0179 |
83734 | ATG10 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.47e-42 | 1.68e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0006984 | Colorectum | AD | ER-nucleus signaling pathway | 21/3918 | 46/18723 | 1.47e-04 | 2.08e-03 | 21 |
GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00069841 | Colorectum | SER | ER-nucleus signaling pathway | 15/2897 | 46/18723 | 2.92e-03 | 2.59e-02 | 15 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00349762 | Colorectum | MSS | response to endoplasmic reticulum stress | 81/3467 | 256/18723 | 2.65e-07 | 1.10e-05 | 81 |
GO:00069842 | Colorectum | MSS | ER-nucleus signaling pathway | 19/3467 | 46/18723 | 2.79e-04 | 3.69e-03 | 19 |
GO:0006983 | Colorectum | MSS | ER overload response | 7/3467 | 13/18723 | 4.46e-03 | 3.15e-02 | 7 |
GO:00349763 | Colorectum | MSI-H | response to endoplasmic reticulum stress | 39/1319 | 256/18723 | 4.12e-06 | 2.20e-04 | 39 |
GO:00162363 | Colorectum | FAP | macroautophagy | 70/2622 | 291/18723 | 2.73e-06 | 1.02e-04 | 70 |
GO:00349764 | Colorectum | FAP | response to endoplasmic reticulum stress | 61/2622 | 256/18723 | 1.58e-05 | 4.10e-04 | 61 |
GO:00069843 | Colorectum | FAP | ER-nucleus signaling pathway | 17/2622 | 46/18723 | 8.85e-05 | 1.57e-03 | 17 |
GO:00069831 | Colorectum | FAP | ER overload response | 6/2622 | 13/18723 | 5.32e-03 | 3.49e-02 | 6 |
GO:00162364 | Colorectum | CRC | macroautophagy | 51/2078 | 291/18723 | 6.40e-04 | 8.48e-03 | 51 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATG10 | SNV | Missense_Mutation | novel | c.205C>G | p.Leu69Val | p.L69V | Q9H0Y0 | protein_coding | tolerated(0.18) | benign(0.115) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ATG10 | SNV | Missense_Mutation | c.397N>A | p.His133Asn | p.H133N | Q9H0Y0 | protein_coding | tolerated(0.07) | possibly_damaging(0.565) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ATG10 | SNV | Missense_Mutation | c.265N>C | p.Ala89Pro | p.A89P | Q9H0Y0 | protein_coding | tolerated(0.07) | possibly_damaging(0.446) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATG10 | SNV | Missense_Mutation | c.72N>T | p.Gln24His | p.Q24H | Q9H0Y0 | protein_coding | deleterious(0) | possibly_damaging(0.753) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATG10 | SNV | Missense_Mutation | novel | c.219N>T | p.Glu73Asp | p.E73D | Q9H0Y0 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATG10 | SNV | Missense_Mutation | novel | c.637N>C | p.Ser213Pro | p.S213P | Q9H0Y0 | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATG10 | SNV | Missense_Mutation | novel | c.153N>T | p.Lys51Asn | p.K51N | Q9H0Y0 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATG10 | SNV | Missense_Mutation | novel | c.31A>G | p.Thr11Ala | p.T11A | Q9H0Y0 | protein_coding | tolerated(0.73) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ATG10 | SNV | Missense_Mutation | novel | c.452N>G | p.Gln151Arg | p.Q151R | Q9H0Y0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ATG10 | SNV | Missense_Mutation | novel | c.545T>G | p.Ile182Ser | p.I182S | Q9H0Y0 | protein_coding | tolerated(0.74) | benign(0.057) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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